305 Dimethylarsine Dimethylarsine is an exogenous liquid with the formula C2H7As and an average molecular weight of 106.00 g/mol. Dimethylarsine belongs to the organoarsenic compounds, a subclass of organometalloid compounds within the organic compounds. This compound has been recorded as being found in or released from fermentation processes for beer. The compound interacts with 32 recorded protein targets. Arsenic binds to actin, specifically ACTA1, ACTA2, ACTB, and ACTG1. It also binds to the estrogen receptor (ESR1), the glucocorticoid receptor (NR3C1), and haptoglobin. Binding to hemoglobin subunit alpha (HBA1) and hemoglobin subunit beta (HBB) is also observed. Furthermore, arsenic binds to mitochondrial glutathione reductase (GSR), which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. Arsenic binding of XPA is believed to induce carcinogenesis by affecting DNA repair. Regarding energy production, arsenic disrupts ATP production through several mechanisms. It inhibits pyruvate dehydrogenase—specifically the PDHA1, PDHA2, and PDHB subunits and the DLAT component of the pyruvate dehydrogenase complex—at the level of the citric acid cycle. By competing with phosphate, it uncouples oxidative phosphorylation, thereby inhibiting ATP synthesis, mitochondrial respiration, and the energy-linked reduction of NAD+. Additionally, hydrogen peroxide production is increased, which may lead to oxidative stress and the formation of reactive oxygen species. 593-57-7 79055 C2H7As 105.976370 No data. -136.1°C Oral (L2) ; inhalation (L2); dermal (L2) Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17) Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20) 3, not classifiable as to its carcinogenicity to humans. (L135) Dimethylarsine is found in marine biological systems. (L388) Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134) Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20) Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1). Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20) 2009-03-06T18:58:29Z 2026-08-22T09:57:52Z Metallothionein-2 (P02795) Metallothionein-1G (P13640) Metallothionein-1H (P80294) Metallothionein-3 (P25713) Metallothionein-1F (P04733) Metallothionein-1E (P04732) Metallothionein-1X (P80297) Metallothionein-1A (P04731) Metallothionein-1B (P07438) Metallothionein-1M (Q8N339) Metallothionein-4 (P47944) Metallothionein-1L (Q93083) Arsenite methyltransferase (Q9HBK9) (L92) C062856 Dimethylarsine true Arsenite methyltransferase (Q9HBK9) (L92) Metallothionein-2 (P02795) Metallothionein-1G (P13640) Metallothionein-1H (P80294) Metallothionein-3 (P25713) Metallothionein-1F (P04733) Metallothionein-1E (P04732) Metallothionein-1X (P80297) Metallothionein-1A (P04731) Metallothionein-1B (P07438) Metallothionein-1M (Q8N339) Metallothionein-4 (P47944) Metallothionein-1L (Q93083) (L92) C[AsH]C C2H7As InChI=1S/C2H7As/c1-3-2/h3H,1-2H3 HBNBMOGARBJBHS-UHFFFAOYSA-N 105.9986 105.976371641 Exogenous Liquid 71387 CHEM000255 NS00121835 dimethylarsane 0 11.8982 7.439309254680264 0 0 0 0 0 0.20 -0.19 6.78e+01 g/l Organic compounds Organometallic compounds Organometalloid compounds Organoarsenic compounds 59 CED0005149 HBNBMOGARBJBHS-UHFFFAOYSA-N 40000000000000000000000000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000000000000000000000000000000200000000000000000000000000000000000000000000000000000000000000000000000000000000000008000000000000000000 4000000000040000000000000000008000000000000000000000000000000000400000000000000000000000000000000000000000000000200000000000000000000000000000000000000000000000000000000000000000000000000000000000001000000004000020040000004000000000000000000000000000000000000000000080000000000000180000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001000000000000000000000000 776t3gAAAAAQAAAAAwAAAAAAAAADAAAAAgAAAIABBgBgAAAAAQMhIDAAAAAB AwYAYAAAAAEDCwABAAECAEIAAAAAFwQAAAAAAAAAFg== 2026-09-19T03:59:37Z