617 Methiochlor Methiochlor is a DDT-like insecticide that is much more biodegradable in the environment. 19679-38-0 29738 C16H15Cl3S2 375.968070 No data. Oral Sodium/potassium-transporting ATPase subunit alpha-1 (P05023) Sodium/potassium-transporting ATPase subunit alpha-2 (P50993) Sodium/potassium-transporting ATPase subunit alpha-3 (P13637) Sodium/potassium-transporting ATPase subunit alpha-4 (Q13733) Sodium/potassium-transporting ATPase subunit beta-1 (P05026) Sodium/potassium-transporting ATPase subunit beta-2 (P14415) Sodium/potassium-transporting ATPase subunit beta-3 (P54709) Sodium/potassium-transporting ATPase gamma chain (P54710) Calcium-transporting ATPase type 2C member 1 (P98194) Calcium-transporting ATPase type 2C member 2(O75185) Plasma membrane calcium-transporting ATPase 1 (P20020) Plasma membrane calcium-transporting ATPase 2(Q01814) Plasma membrane calcium-transporting ATPase 3(Q16720) Plasma membrane calcium-transporting ATPase 4(P23634) Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(O14983) Sarcoplasmic/endoplasmic reticulum calcium ATPase 2(P16615) Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (Q93084) (T10) At least four mechanisms, possibly all functioning simultaneously. Methiochlor reduces potassium transport across the membrane. Methiochlor alters the porous channels through which sodium ions pass. These channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization. Methiochlor inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. Methiochlor also inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. All these inhibited functions reduce the rate of depolarization and increase the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (T10) Methiochlor is proposed to be metabolized by oxidation to 2-(p-methylsulfinylphenyl)-2-(p - methylthiophenyl) - 1,1,1 - trichloroethane and by further oxidation to the corresponding bis-sulfoxide and bis-sulfone (A284). No indication of carcinogenicity to humans (not listed by IARC). No data. Hyperexcitability, anxiety (T10) Tremor (peripheral) (T10) 2009-03-06T18:59:14Z 2026-04-06T12:10:09Z No data. Methiochlor true CSC1=CC=C(C=C1)C(C1=CC=C(SC)C=C1)C(Cl)(Cl)Cl C16H15Cl3S2 InChI=1S/C16H15Cl3S2/c1-20-13-7-3-11(4-8-13)15(16(17,18)19)12-5-9-14(21-2)10-6-12/h3-10,15H,1-2H3 LBWJWHHOEQICIL-UHFFFAOYSA-N 377.779 375.968074981 Exogenous Solid 27634 CHEM000548 NS00123079 1-(methylsulfanyl)-4-{2,2,2-trichloro-1-[4-(methylsulfanyl)phenyl]ethyl}benzene