681 Salcomine Salcomine is an exogenous solid with the formula C16H16CoN2O2 and an average molecular weight of 327.24 g/mol. Salcomine belongs to the carbonyl compounds, a subclass of organooxygen compounds within the organic compounds. It is a coordination complex between cobalt and a salen ligand that can be used as a catalyst for the oxidation of 2,6-disubstituted phenols by dioxygen gas. The compound interacts with various protein targets through its cobalt component. Cobalt inhibits heme synthesis by preventing the synthesis of 5-aminolaevulinate via the inhibition of 5-aminolevulinate synthase, specifically the mitochondrial erythroid-specific (ALAS2) and non-specific (ALAS1) forms. It further inhibits carbonic anhydrases, including Carbonic anhydrase 1 (CA1), Carbonic anhydrase 2 (CA2), and Carbonic anhydrase 4 (CA4). Cobalt also inhibits DNA repair by interacting with zinc finger DNA repair proteins, such as Poly [ADP-ribose] polymerase 1 (PARP1). Additionally, cobalt blocks high-voltage-activated calcium channels, which may impair neurotransmission; targets include Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), alpha-1D (CACNA1D), alpha-1S (CACNA1S), beta-1 (CACNB1), and 10 other proteins. Immunosensitization occurs when cobalt interacts with specific IgE antibodies and specific IgA antibodies, including Immunoglobulin heavy constant alpha 1 (IGHA1) and Immunoglobulin heavy constant alpha 2 (IGHA2). Finally, radioactive cobalt is capable of damaging lipids, RNA, and DNA through ionizing events. 14167-18-1 11012797 C16H16CoN2O2 327.054380 Red crystals. Inhalation (L29) ; oral (L29) ; dermal (L29) Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29) Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29) 2B, possibly carcinogenic to humans. (L135) Salcomine can be used as a catalyst for the oxidation of 2,6-disubstituted phenols by dioxygen gas. (L499) Chronic Inhalation: 0.0001 mg/m3 (L134) Intermediate Oral: 0.01 mg/kg/day (L134) Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitis. Cobalt may also have mutagenic and carcinogenic effects. (L29, L30) Cobalt inhalation can cause asthma-like breathing problems. Skin contact is known to result in contact dermatitis, which is characterized by irritation and rashes. Ingesting large amounts of cobalt may cause nausea and vomiting. (L2090) Treatment of cobalt poisoning is symptomatic. (L29) 2009-03-22T21:48:07Z 2026-04-03T14:31:57Z Serum albumin (P02768) (A39) C003955 Salcomine true Serum albumin (P02768) (A39) [Co].O=C1C=CC=C\C1=C\NCCN\C=C1\C=CC=CC1=O C16H16CoN2O2 InChI=1S/C16H16N2O2.Co/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;/h1-8,11-12,17-18H,9-10H2;/b13-11-,14-12-; FIONSUNUNBIGCA-MJBGKLQRSA-N 327.2436 327.05437796 Exogenous Solid 21160236 CHEM000607 DTXSID1065718 NS00024593 58.2 84.52099999999999 29.361924916484263 5 4 2 4.781708387075765 0 2 Organic compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds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c400200500080000000004102008000000420002c408c30010020643000a00000c6110c00020000000092100000620000000401804000003240040422000049000c300014004002002000040054140001200080508101c0041118000002510002004000080ce0800808020200086c0008111c0012444014020000080000408000004300200810c00000000840016c25100ac00002884108401000030000c00210008000040400001201c00000040102800000000002004000090002000800000000100c000008000000080400401a200000100010804200060000020050000003 776t3gAAAAAQAAAAAwAAAAAAAAAVAAAAFQAAAIABGyCAAAAAAQgAKAAAAAMC BgAoAAAAAwQGAGgAAAADAwEGAGgAAAADAwEGAGgAAAADAwEGAGgAAAADAwEG ACgAAAADBAYAaAAAAAMDAQcAaAAAAAMCAQYAYAAAAAICBgBgAAAAAgIHAGgA AAADAgEGAGgAAAADAwEGACgAAAADBAYAaAAAAAMDAQYAaAAAAAMDAQYAaAAA AAMDAQYAaAAAAAMDAQYAKAAAAAMECAAoAAAAAwILAQIoAgIDIAMEKAIEBSAF BigCBgckAwcIKgICAgIJCAkkAwkKAAoLAAsMAAwNJAMNDioCAgIMEw4PJAMP ECgCEBEgERIoAhITIBMUKAIHAiATDiBCAgAAAAYCBwYFBAMGDxAREhMOFwQA AAAAAAAAFg== 2026-09-19T03:59:46Z