ContaminantDB: Zinc phosphate

Identification Taxonomy Biological Properties Physical Properties Toxicity Profile Spectra Concentrations Links References Targets (1)XML

Record Information

Version

1.0

Creation Date

2009-03-27 01:24:19 UTC

Update Date

2026-04-05 15:39:39 UTC

Accession Number

CHEM000665

Identification

Common Name

Zinc phosphate

Class

Small Molecule

Description

Zinc phosphate is a phosphate of zinc. It is found naturally as the minerals hopeite, parahopeite, and tarbuttite. Zinc phosphate is used as a dental cement and corrosion resistant coating. Zinc is a metallic element with the atomic number 30. It is found in nature most often as the mineral sphalerite. Though excess zinc in harmful, in smaller amounts it is an essential element for life, as it is a cofactor for over 300 enzymes and is found in just as many transcription factors. (2, 3, 4) Zinc phosphate (Zn3(PO4)2) is an inorganic chemical compound used as a corrosion resistant coating on metal surfaces either as part of an electroplating process or applied as a primer pigment (see also red lead). Zinc phosphate coats better on a crystalline structure than bare metal, so a seeding agent is often used as a pre-treatment. One common agent is sodium pyrophosphate.

Contaminant Sources

HPV EPA Chemicals
OECD HPV Chemicals
T3DB toxins

Contaminant Type

Household Toxin
Industrial/Workplace Toxin
Inorganic Compound
Natural Compound
Zinc Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Zinc phosphoric acid	Generator
Zinc phosphate (2:3), tetrahydrate	MeSH
Zinc hydrogen phosphate	MeSH
Hopeite	MeSH

Chemical Formula

O₈P₂Zn₃

Average Molecular Mass

386.170 g/mol

Monoisotopic Mass

381.694 g/mol

CAS Registry Number

7779-90-0

IUPAC Name

trizinc(2+) ion diphosphate

Traditional Name

trizinc(2+) ion diphosphate

SMILES

[Zn++].[Zn++].[Zn++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI Identifier

InChI=1S/2H3O4P.3Zn/c2*1-5(2,3)4;;;/h2*(H3,1,2,3,4);;;/q;;3*+2/p-6

InChI Key

LRXTYHSAJDENHV-UHFFFAOYSA-H

Chemical Taxonomy

Description

belongs to the class of inorganic compounds known as transition metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is a transition metal.

Kingdom

Inorganic compounds

Super Class

Mixed metal/non-metal compounds

Class

Transition metal oxoanionic compounds

Sub Class

Transition metal phosphates

Direct Parent

Transition metal phosphates

Alternative Parents

Substituents

Transition metal phosphate
Inorganic oxide
Inorganic salt

Molecular Framework

Not Available

External Descriptors

Not Available

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Actin Cytoskeleton
Cell surface
Cytoplasm
Cytosol
Early endosome
Endocytic Vesicle
Endoplasmic reticulum
Endosome
Extracellular
Extracellular matrix
Late endosome
Lysosome
Membrane Fraction
Microsome
Microtubule
Mitochondrion
Nuclear Matrix
Plasma Membrane
Ribosome
Secretory vesicle
Soluble Fraction
Synaptic Vesicle
Tubulin

Biofluid Locations

Not Available

Tissue Locations

Not Available

Pathways

Name	SMPDB Link	KEGG Link
Apoptosis	Not Available	map04210
Pentose Phosphate Pathway	SMP00031	map00030
Nucleotide Excision Repair	SMP00478	map03420
Endocytosis	Not Available	map04144
Rna degradation	Not Available	map03018
Osteoclast differentiation	Not Available	map04380
Mineral absorption	Not Available	map04978
Galactose Metabolism	SMP00043	map00052
Circadian rhythm	Not Available	map04710
Cell cycle	Not Available	map04110
Tetracyclines	Not Available	Not Available
Starch and Sucrose Metabolism	SMP00058	map00500
Proteasome	Not Available	Not Available
Pentose and glucuronate interconversions	Not Available	map00040
Carbon Metabolism	Not Available	Not Available
Ascorbate and aldarate metabolism	Not Available	map00053

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Physical Properties

State

Solid

Appearance

White crystals.

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Property	Value	Source
logP	-1	ChemAxon
pKa (Strongest Acidic)	1.8	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	86.25 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	11.29 m³·mol⁻¹	ChemAxon
Polarizability	4.93 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-001i-0009000000-9f11118be028a37a4e05	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-001i-0009000000-9f11118be028a37a4e05	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-001i-0009000000-9f11118be028a37a4e05	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-001i-0009000000-39586e13b1f2e1038a8b	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-0009000000-39586e13b1f2e1038a8b	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-001i-0009000000-39586e13b1f2e1038a8b	Spectrum

Toxicity Profile

Route of Exposure

Inhalation (3) ; oral (3) ; dermal (3)

Mechanism of Toxicity

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (2, 3, 1)

Metabolism

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (3)

Toxicity Values

Not Available

Lethal Dose

Not Available

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Uses/Sources

Zinc phosphate is used as a dental cement and corrosion resistant coating. (4)

Minimum Risk Level

Intermediate Oral: 0.3 mg/kg/day (6) Chronic Oral: 0.3 mg/kg/day (6)

Health Effects

Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (3)

Symptoms

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (3)

Treatment

Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (3)

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

Not Available

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Zinc phosphate

Chemspider ID

Not Available

ChEBI ID

Not Available

PubChem Compound ID

24519

Kegg Compound ID

Not Available

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Not Available

General References

Not Available

Zinc phosphate (CHEM000665)

Structure for CHEM000665: Zinc phosphate