772 Methanol Methanol is the simplest alcohol, and is a light, volatile, colourless, flammable, poisonous liquid with a distinctive odor that is somewhat milder and sweeter than ethanol (Wikipedia). Methanol is responsible for accidental, suicidal, and epidemic poisonings, resulting in death or permanent sequelae. Toxicity is due to the metabolic products of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase. (A7768). The rapid and accurate diagnosis of toxic alcohol poisoning due to methanol (methyl alcohol) is paramount in preventing serious adverse outcomes. The quantitative measurement of specific serum levels of methanol using gas chromatography is expensive, time consuming and generally only available at major tertiary-care facilities. (A7769). 67-56-1 887 CH4O 32.026220 -97.6°C 1000 mg/mL at 25°C Oral (T10) The target of methanol in the eye is the retina, specifically the optic disk and optic nerve. Muller cells and rod and cone cells are altered functionally and structurally, because cytochrome oxidase activity in mitochondria is inhibited, resulting in a reduction in ATP. (T10) Methanol is metabolized to formaldehyde by alcohol dehydrogenase, then from that to formate by formaldehyde dehydrogenase, and then to carbon dioxide by limited H4 folate. (T10) No indication of carcinogenicity to humans (not listed by IARC). Methanol is found in a host of consumer products, including windshield washer fluid, and is used in the manufacture of formaldehyde. (T10) Acute methanol poisoning in humans is characterized by an asymptomatic period of 12h to 24h followed by formic acidemia, ocular toxicity, coma, and in extreme cases death. Visual disturbances develop between 18h to 48h after ingestion and range from mild photophobia and blurred vision to markedly reduced visual acuity and complete blindness. (T10) Methanol can produce sensory irritation and narcosis at airborne concentrations below those which produce organ system pathology. (T10) 2009-05-06T21:41:26Z 2026-03-26T19:55:31Z http://en.wikipedia.org/wiki/Methanol C00132 17790 3-OH-BENZYL-ALCOHOL D000432 Methanol MOH 1710 true CO CH4O InChI=1S/CH4O/c1-2/h2H,1H3 OKKJLVBELUTLKV-UHFFFAOYSA-N 32.0419 32.02621475 Endogenous Liquid -0.77 HMDB01875 CHEMBL14688 864 Cummings, Donald Ray. Process for production of methanol from a methane gas stream. PCT Int. Appl. (2007), 21pp. CHEM000694 DTXSID2021731 NS00001876 methanol