T3D1263

1267 T3D1263

Triphenyltin hydride

Triphenyltin hydride (C18H16Sn) is an exogenous organic compound with an average molecular weight of 351.03 g/mol. It exists as a solid at room temperature. Triphenyltin hydride belongs to the benzene and substituted derivatives, a class of benzenoids within the organic compounds. This compound is present in polyvinyl chloride and has been recorded as being released from electrical and electronic equipment, specifically video games. The compound interacts with twelve recorded protein targets. It acts as a weak inhibitor of alcohol dehydrogenase, affecting proteins including alcohol dehydrogenase 1A (ADH1A), alcohol dehydrogenase 1C (ADH1C), and all-trans-retinol dehydrogenase [NAD(+)] (ADH1B and ADH4). Triphenyltin hydride also targets the proteasome subunit beta type-5 (PSMB5) by binding to the beta-5 subunit, which inhibits the chymotrypsin-like activity of cellular and 20S proteasomes, resulting in apoptosis. Additionally, as an organotin and endocrine disruptor, it is believed to contribute to obesity by inducing adipocyte differentiation through the inappropriate activation of peroxisome proliferator-activated receptor gamma (PPARG) and retinoic acid receptors alpha, beta, and gamma (RARA, RARB, and RARG). 892-20-6

5357402

C18H16Sn

351.019570 White powder.

28°C

156°C (0.15 mm Hg)

Oral (L308) ; inhalation (L308) ; dermal (L308)

Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184)

Though tin metal is very poorly absorbed, tin compounds may be absorbed via oral, inhalation, or dermal routes, with organotin compounds being much more readily absorbed than inorganic tin compounds. Tin may enter the bloodstream and bind to hemoglobin, where it is distributed and accumulates mainly in the kidney, liver, lung, and bone. Organotin compounds may undergo dealkylation, hydroxylation, dearylation, and oxidation catalyzed by cytochrome P-450 enzymes in the liver. The alkyl products of dealkylation are conjugated with glutathione and further metabolized to mercapturic acid derivatives. Tin and its metabolites are excreted mainly in the urine and feces. (L308) No indication of carcinogenicity to humans (not listed by IARC).

Breathing or swallowing, or skin contact with organotins, can interfere with the way the brain and nervous system work, causing death in severe cases. Organic tin compounds may also damage the immune and reproductive system. (L307, L308)

Inorganic or organic tin compounds placed on the skin or in the eyes can produce skin and eye irritation. (L308)

2009-06-19T21:58:31Z

2026-04-06T08:19:30Z

Hemoglobin subunit alpha (P69905) Hemoglobin subunit beta (P68871) Hemoglobin subunit gamma-1 (P69891) Hemoglobin subunit gamma-2 (P69892) Hemoglobin subunit delta (P02042) Hemoglobin subunit epsilon (P02100) Hemoglobin subunit theta-1 (P09105) Hemoglobin subunit zeta (P02008) Hemoglobin subunit mu (Q6B0K9) Cytochrome P450 2C6 (P05178) (L308)

30537

C030665

Triphenyltin hydride

true

Cytochrome P450 2C6 (P05178) (L308)

C1=CC=C(C=C1)[SnH](C1=CC=CC=C1)C1=CC=CC=C1

C18H16Sn

InChI=1S/3C6H5.Sn.H/c3*1-2-4-6-5-3-1;;/h3*1-5H;;

NFHRNKANAAGQOH-UHFFFAOYSA-N

351.03

352.027397083

Exogenous Solid

CHEM001084

DTXSID40893312

NS00114222

77.22290000000002

30.387750958248464

5.22

-4.47

1.18e-02 g/l

Organic compounds Benzenoids Benzene and substituted derivatives

CED0008342

NFHRNKANAAGQOH-UHFFFAOYSA-N

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2026-09-19T04:00:03Z