1491 Aluminium diacetate hydroxide Aluminium diacetate hydroxide is an exogenous solid with the formula C4H7AlO5 and an average molecular weight of 162.08 g/mol. Aluminium diacetate hydroxide belongs to the carboxylic acid derivatives, a subclass of carboxylic acids and derivatives within the organic compounds. It is utilized industrially as a biocide and an astringent. The compound interacts with various protein targets. It can interact with the estrogen receptor (ESR1), which may increase the expression of estrogen-related genes and contribute to the progression of breast cancer. Additionally, certain aluminum salts activate the NALP3 inflammasome, inducing the production of interleukins. Aluminium diacetate hydroxide also binds with dietary phosphorus, impairing its gastrointestinal absorption. This reduction in phosphate body burden can result in rickets and osteomalacia, a condition characterized by the softening of the bones due to defective bone mineralization. 142-03-0 16682993 C4H7AlO5 163.018710 White powder. Oral (L739) ; inhalation (L739) The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (L739) Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). Aluminium diacetate hydroxide is used as an antiseptic. (L747) Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) 2009-06-19T21:58:51Z 2026-05-14T19:52:43Z Aluminium diacetate hydroxide DB15679 15904 true CC(=O)O[Al](O)OC(C)=O C4H7AlO5 InChI=1S/2C2H4O2.Al.H2O/c2*1-2(3)4;;/h2*1H3,(H,3,4);;1H2/q;;+3;/p-3 HQQUTGFAWJNQIP-UHFFFAOYSA-K 162.0769 162.010886775 Exogenous Solid -0.4 21106083 CHEM001263 DTXSID7044552 NS00079292 (acetyloxy)(hydroxy)alumanyl acetate 72.83000000000001 25.9968 13.602460021895425 4 3 1 13.576441283676186 -3.421464582520036 0 0 0.21 -1.19 1.04e+01 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives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c00010000443000a00000801100000000000000000020004201000000000040000002000000a0000009020c2000400040020000000000403000002000801000046004110800000010000200440008044000000800020088000000100400024440100000040800000000000841000000004000000008000024001002c0000000000800000000000200000000000004040000000080000000000000000000400000400800000000080000000000000000000000000000000000000000400000004000000000000050000020 776t3gAAAAAQAAAAAwAAAAAAAAAKAAAACQAAAIABBgBgAAAAAQMGACgAAAAD BAgAKAAAAAMCCAAoAAAAAwINICgAAAADAwgAYAAAAAEBCAAoAAAAAwIGACgA AAADBAYAYAAAAAEDCAAoAAAAAwILAAEAAQIoAgEDIAMEAAQFAAQGAAYHIAcI AAcJKAJCAAAAABcEAAAAAAAAABY= 2026-09-19T04:00:06Z