1493 Aloglutamol Aloglutamol is an exogenous solid with the formula C10H24AlNO12 and an average molecular weight of 377.28 g/mol. Aloglutamol belongs to the carbohydrates and carbohydrate conjugates, a subclass of organooxygen compounds within the organic compounds. The compound interacts with various protein targets. It can interact with the estrogen receptor (ESR1), which may increase the expression of estrogen-related genes and contribute to the progression of breast cancer. Additionally, certain aluminum salts activate the NALP3 inflammasome, inducing the production of interleukins. Aloglutamol also binds with dietary phosphorus, impairing its gastrointestinal absorption. This resulting decrease in the phosphate body burden leads to rickets and osteomalacia, a condition characterized by softening of the bones due to defective bone mineralization. 13755-41-4 72941505 C10H24AlNO12 White powder. Oral (L739) ; inhalation (L739) The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (L739) Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). Aloglutamol is an antacid. (L744) Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) 2009-06-19T21:58:51Z 2026-05-14T19:35:38Z C012712 Aloglutamol DB13650 true NC(CO)(CO)CO.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O[Al](O)O C10H24AlNO12 InChI=1S/C6H12O7.C4H11NO3.Al.2H2O/c7-1-2(8)3(9)4(10)5(11)6(12)13;5-4(1-6,2-7)3-8;;;/h2-5,7-11H,1H2,(H,12,13);6-8H,1-3,5H2;;2*1H2/q;;+3;;/p-3/t2-,3-,4+,5-;;;;/m1..../s1 GJJYZOBRHIMORS-GQOAHPRESA-K 377.2786 377.111388678 Exogenous Solid 28426726 CHEM001265 2-amino-2-(hydroxymethyl)propane-1,3-diol; dihydroxyalumanyl (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate 167.91 42.4726 21.729551383495696 10 8 7 11.683545088531094 -2.835118099124813 0 0 Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates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 776t3gAAAAAQAAAAAwAAAAAAAAAYAAAAFgAAAIABBwBgAAAAAQIGACAAAAAE BgBgAAAAAgIIAGAAAAABAQYAYAAAAAICCABgAAAAAQEGAGAAAAACAggAYAAA AAEBCABgAAAAAQEGAGAAAAACAgYgNAAAAAEBBAgAYAAAAAEBBiA0AAAAAQEE CABgAAAAAQEGIDQAAAACAQQIAGAAAAABAQYgNAAAAAEBBAgAYAAAAAEBBgAo AAAAAwQIACgAAAADAggAKAAAAAMCDSAoAAAAAwMIAGAAAAABAQgAYAAAAAEB CwABAAECAAIDAAEEAAQFAAEGAAYHAAgJAAkKAAoLAAoMAAwNAAwOAA4PAA4Q ABARABASABITKAISFCAUFQAVFgAVFwBCAAAAABcEAAAAAAAAABY= 2026-09-19T04:00:06Z