1529 Methylaluminoxane Methylaluminoxane is an exogenous organic metal salt with the formula C3H11AlO and an average molecular weight of 90.10 g/mol. Methylaluminoxane belongs to the organic metal salts, a class of organic salts within the organic compounds. At room temperature, this compound exists as a solid and is used as an industrial catalyst. Regarding its biological effects, methylaluminoxane interacts with the estrogen receptor (ESR1), which can increase the expression of estrogen-related genes and contribute to the progression of breast cancer. Additionally, certain aluminum salts activate the NALP3 inflammasome, inducing immune responses and the production of interleukins. Furthermore, aluminum binds with dietary phosphorus, impairing its gastrointestinal absorption. This reduction in phosphate body burden results in rickets and osteomalacia, a condition characterized by the softening of the bones due to defective bone mineralization. 120144-90-3 16693024 C3H11AlO 58.015 White powder. Oral (L739) ; inhalation (L739) The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (L739) Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). Methylaluminoxane is most well known for being a co-catalyst for olefin polymerizations of the Ziegler-Natta type. (L773) Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) 2009-06-19T21:58:54Z 2026-08-26T00:15:41Z Methylaluminoxane true C.C.[Al+].C[O-] C3H11AlO InChI=1S/CH3O.2CH4.Al/c1-2;;;/h1H3;2*1H4;/q-1;;;+1 WZCSPXAKFFCXQR-UHFFFAOYSA-N 90.102 90.0625285 Exogenous Solid 10687336 CHEM001295 NS00120491 methoxy(dimethyl)alumane 23.06 18.8116 3.063145763329802 0 1 0 15.775593215075904 -2.459555527725798 0 0 -0.64 0.68 2.80e+02 g/l Organic compounds Organic salts Organic metal salts 279 CED0011775 WZCSPXAKFFCXQR-UHFFFAOYSA-N 400000000000000000000000000000000000000000000000000000000001000000000000000000000000000000000000000000000000000000000000000000000000000000000000040000000000000000000000000000000000000000000000000008000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000080000000000000 2000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000400000000000000000000000000000000000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000000000000000000000000020040000004000000000000000000000010000000000000000000080000000000084100000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010000000 776t3gAAAAAQAAAAAwAAAAAAAAAFAAAAAQAAAIABBgBAAAAABAYAQAAAAAQN IIoAAAABAgIGAGAAAAABAwggIgAAAP8BCwMEAEIAAAAAFwQAAAAAAAAAFg== 2026-09-19T04:00:07Z