1553 Sodium aluminum phosphate Sodium aluminum phosphate is an exogenous inorganic compound with the formula AlNaO4P and an average molecular weight of 144.94 g/mol. It exists as a solid at room temperature. Sodium aluminum phosphate belongs to the post-transition metal phosphates, a subclass of post-transition metal oxoanionic compounds within the inorganic compounds. In industrial applications, this compound is utilized as a humectant, drier, thickening agent, emulsifier, leavening agent, and anti-caking agent. Regarding its biological effects, sodium aluminum phosphate can interact with the estrogen receptor (ESR1), which may increase the expression of estrogen-related genes and contribute to the progression of breast cancer. Furthermore, certain aluminum salts can activate the NALP3 inflammasome, inducing immune responses and the production of interleukins. Additionally, aluminum binds with dietary phosphorus to impair its gastrointestinal absorption. This reduction in the phosphate body burden results in rickets and osteomalacia, which is the softening of the bones caused by defective bone mineralization. 7785-88-8 3032541 AlNaO4P 144.943 White powder. Oral (L739) ; inhalation (L739) The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (L739) Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. 2009-06-19T21:58:56Z 2026-04-17T19:09:16Z C040382 Sodium aluminum phosphate 16146 true [Na+].[Al+3].[O-]P([O-])([O-])=O AlNaO4P InChI=1S/Al.Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q+3;+1;/p-3 GHHVYBBTKTVOPA-UHFFFAOYSA-K 144.9427 144.924728116 Exogenous Solid 2297490 CHEM001317 NS00081082 86.25 11.2868 4.932886848468115 0 4 0 1.7961261340181292 -2 0 Inorganic compounds Mixed metal/non-metal compounds Post-transition metal oxoanionic compounds Post-transition metal phosphates 10 CED0019148 GHHVYBBTKTVOPA-UHFFFAOYSA-K 100000000000000000000000080000000000000000000000000000000000000000000000000000000000000000000000002000000000000000000100000000000000000000020000000000000001000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000040000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010000000000000000000000000000000000 100000000000000000000000000000000040000002000400000000000000000000000000000000000000000022000000004000000004400008000000010040000000300000000000042080000000000000000020000000000000000000000000040000000000000401000002000801000000004110000000010000200400008040000000000020000000000100400124000100000000b00000000000a60000000000000000008000020001002c000000000000010000000000000000c000000040000021000000000000080000000000000400000003000000000000000000000000000000000000000000000000000004000000000000050000000 776t3gAAAAAQAAAAAwAAAAAAAAAHAAAABAAAAIABCyAKAAAAAQENIAoAAAAD AQggIgAAAP8BDwAgAAAABQggIgAAAP8BCCAiAAAA/wEIACgAAAADAgsCAwAD BAADBQADBggCQgAAAAAXBAAAAAAAAAAW 2026-09-19T04:00:07Z