1565 Tritetradecylaluminum Tritetradecylaluminum is an exogenous organoaluminum compound with the formula C42H87Al. It exists as a solid at room temperature. Tritetradecylaluminum belongs to the hydrocarbon derivatives, a superclass within the organic compounds. With an average molecular weight of 619.12 g/mol, Tritetradecylaluminum is a heavy molecule. Regarding biological interactions, aluminum can interact with estrogen receptors (ESR1), increasing the expression of estrogen-related genes and contributing to the progression of breast cancer. Certain aluminum salts activate the NALP3 inflammasome, which induces the production of interleukins to trigger immune responses. Additionally, aluminum binds with dietary phosphorus, impairing its gastrointestinal absorption. This decreased phosphate body burden results in rickets and osteomalacia, which is the softening of the bones due to defective bone mineralization. 1529-58-4 16682962 C42H87Al 618.662320 White powder. Oral (L739) ; inhalation (L739) The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (L739) Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) 2009-06-19T21:58:57Z 2026-08-17T20:40:01Z Tritetradecylaluminum 3963 true CCCCCCCCCCCCCC[Al](CCCCCCCCCCCCCC)CCCCCCCCCCCCCC C42H87Al InChI=1S/3C14H29.Al/c3*1-3-5-7-9-11-13-14-12-10-8-6-4-2;/h3*1,3-14H2,2H3; JVIKNVRZMNQFFL-UHFFFAOYSA-N 619.1217 618.662316225 Exogenous Solid 13709820 CHEM001329 NS00081323 tri(tetradecyl)alumane 0 196.4457 91.28379064424816 39 0 0 0 0 10.99 -8.15 4.34e-06 g/l Organic compounds Hydrocarbon derivatives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a000000000008005204000100040020088044002000000800000000041240080000004600204000410210044643000200000c6110401088010000180100000520000000400004001001240000422040000000c20012800000200000000004504000c200400500100010011080010025000021040080006e0800808020050482c0008311c180244008c0a1000082020400000080110110090c01000000860014435004ac00000080108000000080040400200000000840408002200800400400002980800000002004000196000000800020400004800088100001000000028022000005000308042040c0000000050000000 776t3gAAAAAQAAAAAwAAAAAAAAArAAAAKgAAAIABBgBgAAAAAQMGAGAAAAAC AgYAYAAAAAICBgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBgBgAAAAAgIGAGAA AAACAgYAYAAAAAICBgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBgBgAAAAAgIG AGAAAAACAg0gKAAAAAMDBgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBgBgAAAA AgIGAGAAAAACAgYAYAAAAAICBgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBgBg AAAAAgIGAGAAAAACAgYAYAAAAAICBgBgAAAAAgIGAGAAAAABAwYAYAAAAAIC BgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBgBgAAAAAgIGAGAAAAACAgYAYAAA AAICBgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBgBgAAAAAgIGAGAAAAACAgYA YAAAAAICBgBgAAAAAQMLAAEAAQIAAgMAAwQABAUABQYABgcABwgACAkACQoA CgsACwwADA0ADQ4ADg8ADxAAEBEAERIAEhMAExQAFBUAFRYAFhcAFxgAGBkA GRoAGhsAGxwADh0AHR4AHh8AHyAAICEAISIAIiMAIyQAJCUAJSYAJicAJygA KCkAKSoAQgAAAAAXBAAAAAAAAAAW 2026-09-19T04:00:07Z