1591 trans-Dichlorobis-(triphenylphosphine) palladium(II) trans-Dichlorobis-(triphenylphosphine) palladium(II) is an exogenous chemical compound with the formula C36H32Cl2P2Pd. It exists as a solid at room temperature. trans-Dichlorobis-(triphenylphosphine) palladium(II) belongs to the phenylphosphines and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. With an average molecular weight of 703.91 g/mol, trans-Dichlorobis-(triphenylphosphine) palladium(II) is a heavy molecule. The compound interacts with four recorded protein targets. Palladium inhibits creatine kinase M-type (CKM) by forming a complex with its essential SH groups. Additionally, palladium irreversibly inhibits prolyl 4-hydroxylase subunit alpha-1 (P4HA1), prolyl 4-hydroxylase subunit alpha-2 (P4HA2), and transmembrane prolyl 4-hydroxylase (P4HTM) by replacing Fe2+ in the active site to form a strong complex with the enzyme. 965-03-2 138397906 C36H32Cl2P2Pd 211.095690 White powder. Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, and interact with functional groups of macromolecules, such as proteins or DNA. Palladium complexes binding to DNA and RNA leads to strand breakage. Palladium ions are able to inhibit most major cellular functions, including DNA and RNA synthesis. Palladium compounds have been shown to bind to and inhibit various enzymes, including creatine kinase and prolyl hydroxylase. (L798) Palladium may be absorbed through oral, dermal, and inhalation exposure. Once in the body it distributes to the kidney, liver, spleen, lymph nodes, adrenal gland, lung and bone. Palladium's ability to form complexes allows it the bind to amino acids, proteins, DNA, and other macromolecules. Palladium and its metabolites are excreted in the urine and faeces. (A21) No indication of carcinogenicity to humans (not listed by IARC). Contact with palladium may cause palladium sensitivity and allergy. Animal studies have shown that palladium may damage the liver and kidney. (L798) Skin contact with palladium may cause contact dermatitis, erythema, and oedema. (L798) 2009-06-19T21:59:00Z 2026-04-06T11:47:54Z Metallothionein-2 (P02795) Metallothionein-1G (P13640) Metallothionein-1H (P80294) Metallothionein-3 (P25713) Metallothionein-1F (P04733) Metallothionein-1E (P04732) Metallothionein-1X (P80297) Metallothionein-1A (P04731) Metallothionein-1B (P07438) Metallothionein-1M (Q8N339) Metallothionein-4 (P47944) Metallothionein-1L (Q93083) (L798) Dichlorobis-(triphenylphosphine) palladium(II), trans- true Metallothionein-2 (P02795) Metallothionein-1G (P13640) Metallothionein-1H (P80294) Metallothionein-3 (P25713) Metallothionein-1F (P04733) Metallothionein-1E (P04732) Metallothionein-1X (P80297) Metallothionein-1A (P04731) Metallothionein-1B (P07438) Metallothionein-1M (Q8N339) Metallothionein-4 (P47944) Metallothionein-1L (Q93083) (L798) Cl[Pd](Cl)(P(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)P(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1 C36H32Cl2P2Pd InChI=1S/2C18H15P.2ClH.Pd/c2*1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;;;/h2*1-15H;2*1H; ILBDOZRDKNIJBS-UHFFFAOYSA-N 703.91 702.039112549 Exogenous Solid 21489420 CHEM001353 NS00122250 0 177.11839999999995 63.45652536456243 8 0 0 0 6 9.21 -8.57 1.88e-06 g/l Organic compounds Benzenoids Benzene and substituted derivatives Phenylphosphines and derivatives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 776t3gAAAAAQAAAAAwAAAAAAAAApAAAALgAAAIABEQAgAAAAAS4gKAAAAAAE EQAgAAAAAQ8AaAAAAAYEAQZAKAAAAAMEBkBoAAAAAwMBBkBoAAAAAwMBBkBo AAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMBBkAoAAAAAwQGQGgAAAADAwEGQGgA AAADAwEGQGgAAAADAwEGQGgAAAADAwEGQGgAAAADAwEGQCgAAAADBAZAaAAA AAMDAQZAaAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMDAQ8AaAAA AAYEAQZAKAAAAAMEBkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAA AwMBBkBoAAAAAwMBBkAoAAAAAwQGQGgAAAADAwEGQGgAAAADAwEGQGgAAAAD AwEGQGgAAAADAwEGQGgAAAADAwEGQCgAAAADBAZAaAAAAAMDAQZAaAAAAAMD AQZAaAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMDAQsAAQABAgABAwADBAAEBWgM BQZoDAYHaAwHCGgMCAloDAMKAAoLaAwLDGgMDA1oDA0OaAwOD2gMAxAAEBFo DBESaAwSE2gMExRoDBQVaAwBFgAWFwAXGGgMGBloDBkaaAwaG2gMGxxoDBYd AB0eaAweH2gMHyBoDCAhaAwhImgMFiMAIyRoDCQlaAwlJmgMJidoDCcoaAwJ BGgMDwpoDBUQaAwcF2gMIh1oDCgjaAxCBgAAAAYFBgcICQQGCwwNDg8KBhES ExQVEAYYGRobHBcGHh8gISIdBiQlJicoIxcEAAAAAAAAABY= 2026-09-19T04:00:08Z