1604 Silver acetylide Silver acetylide is an exogenous organic compound with the formula C2HAg and an average molecular weight of 132.90 g/mol. It exists as a solid at room temperature. Silver acetylide belongs to the acetylides, a superclass within the organic compounds. The compound interacts with 16 recorded protein targets. The silver ion inhibits the activity of NA+,K+-ATPase, which disrupts intracellular ion concentrations; affected proteins include the sodium/potassium-transporting ATPase subunit gamma (FXYD2), sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2), sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3), and four other proteins. Additionally, the silver ion inhibits glutathione peroxidase activity, thereby disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. The proteins involved in this process include epididymal secretory glutathione peroxidase (GPX5), glutathione peroxidase 1 (GPX1), glutathione peroxidase 2 (GPX2), glutathione peroxidase 3 (GPX3), and four other proteins. 7659-31-6 61576 C2HAg White powder. Oral (L808) ; inhalation (L808) ; dermal (L808) Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions and intracellular ion concentrations, respectively. Silver nanoparticles are believed to disrupt the mitochondrial respiratory chain, causing oxidative stress, reduced ATP synthesis, and DNA damage. (L808, A243, A244, A245, A246) Silver and its compounds can be absorbed via inhalation, while silver compounds can also be absorbed orally and dermally. It distributes throughout the body in the blood, particularily to the liver. Insoluble silver salts are transformed into soluble silver sulfide albuminates, bind to amino or carboxyl groups in RNA, DNA, and proteins, or are reduced to metallic silver by ascorbic acid or catecholamines. Metallic silver is oxidized and may deposit in the tissues, causing arygria. Silver is eliminated primarily in the faeces. (L808) No indication of carcinogenicity to humans (not listed by IARC). Silver itself is not toxic to humans, but most silver salts are. In large doses, silver and compounds containing it can be absorbed into the circulatory system and become deposited in various body tissues, leading to argyria, which results in a blue-grayish pigmentation of the skin, eyes, and mucous membranes. Argyria is rare, and although, so far as known, this condition does not otherwise harm a person's health, it is disfiguring and usually permanent. Mild forms of argyria are sometimes mistaken for cyanosis. (L809) Exposure to high levels of silver for a long period of time may result in a condition called arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but does not appear to be harmful to health. Exposure to high levels of silver in the air has resulted in breathing problems, lung and throat irritation, and stomach pains. Skin contact with silver can cause mild allergic reactions such as rash, swelling, and inflammation in some people. (L808) 2009-06-19T21:59:01Z 2026-04-06T11:45:58Z Silver acetylide true [Ag]C#C C2HAg InChI=1S/C2H.Ag/c1-2;/h1H; IHHLODLYMNGWGQ-UHFFFAOYSA-N 132.8975 131.912918052 Exogenous Solid CHEM001364 NS00122216 0 6.983 4.932313363338711 0 0 0 0 0 -0.49 -1.80 2.10e+00 g/l Organic compounds Acetylides 21 CED0009873 IHHLODLYMNGWGQ-UHFFFAOYSA-N 20000000000000000000000000000000000000000000000100000000000010000000000000020000000000000000000000000000000000000000000000000000000000000000000000200000000008000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000 4000000000040000000000000000000000000000000000000000000000000000400000000000000000000000000000000000000000000000200000000000000000000000000000080000000080000000000000000000000000000000000000000000001000000000000020040000004000000000000000020000000000000000000000000080000000000000100000200000000000000000000000000004000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000200000000000000000000000000000000000000000000000 776t3gAAAAAQAAAAAwAAAAAAAAADAAAAAgAAAIABLyAoAAAABwEGACgAAAAC BAYAaAAAAAIDAQsAAQABAggDQgAAAAAXBAAAAAAAAAAW 2026-09-19T04:00:08Z