<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">1720</id>
  <title>T3D1716</title>
  <common-name>Potassium bromate</common-name>
  <description>Potassium bromate is an exogenous inorganic compound with the formula BrKO3 and an average molecular weight of 167.00 g/mol. It exists as a solid at room temperature. Potassium bromate belongs to the alkali metal bromates, a subclass of alkali metal oxoanionic compounds within the inorganic compounds.

In industrial and biological applications, this compound serves as an oxidizing agent, filler, food preservative, and leavening agent. It is specifically utilized as a flour treatment agent. The compound is associated with four recorded protein targets: the chloride channel protein ClC-Ka (CLCNKA) and three subunits of the gamma-aminobutyric acid receptor, namely GABRA1 (alpha-1), GABRB3 (beta-3), and GABRG2 (gamma-2).</description>
  <cas>7758-01-2</cas>
  <pubchem-id>289509</pubchem-id>
  <chemical-formula>BrKO3</chemical-formula>
  <weight>298.168130</weight>
  <appearance>White powder.</appearance>
  <melting-point>350°C</melting-point>
  <boiling-point nil="true"/>
  <density nil="true"/>
  <solubility>69 mg/mL at 20°C [DAGANI,MJ et al. (1985)]</solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure>Oral (L96) ; inhalation (L96) ; dermal (L96)</route-of-exposure>
  <target nil="true"/>
  <mechanism-of-toxicity>Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543)</mechanism-of-toxicity>
  <metabolism>Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626)</metabolism>
  <toxicity>LD50: 321 mg/kg (Oral, Rat) (T14)
LD50: 177 mg/kg (Intraperitoneal, Mouse) (T14) </toxicity>
  <lethaldose nil="true"/>
  <carcinogenicity>2B, possibly carcinogenic to humans. (L135)</carcinogenicity>
  <use-source>Potassium bromate may be used as a flour improver, strengthening the dough and allowing higher rising, as well as in the production of malt barley. However,  its use in food products in now banned in most countries. (L635)</use-source>
  <min-risk-level nil="true"/>
  <health-effects>Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. Bromate is also a potential carcinogen. (L625, L626, L627, L638)</health-effects>
  <symptoms>Bromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. This is called bromism. (L626, L627)</symptoms>
  <treatment>EYES: irrigate opened eyes for several minutes under running water.
      
INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice.
      
SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention.
      
INHALATION: supply fresh air. If required provide artificial respiration.</treatment>
  <created-at type="dateTime">2009-06-22T16:08:29Z</created-at>
  <updated-at type="dateTime">2026-08-29T10:03:18Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia nil="true"/>
  <uniprot-id nil="true"/>
  <kegg-compound-id></kegg-compound-id>
  <omim-id></omim-id>
  <chebi-id></chebi-id>
  <biocyc-id></biocyc-id>
  <ctd-id nil="true"/>
  <stitch-id>Potassium bromate</stitch-id>
  <drugbank-id nil="true"/>
  <pdb-id nil="true"/>
  <actor-id nil="true"/>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles>[K+].[O-][Br](=O)=O</moldb-smiles>
  <moldb-formula>BrKO3</moldb-formula>
  <moldb-inchi>InChI=1S/BrHO3.K/c2-1(3)4;/h(H,2,3,4);/q;+1/p-1</moldb-inchi>
  <moldb-inchikey>OCATYIAKPYKMPG-UHFFFAOYSA-M</moldb-inchikey>
  <moldb-average-mass type="decimal">167.001</moldb-average-mass>
  <moldb-mono-mass type="decimal">165.866788374</moldb-mono-mass>
  <origin>Exogenous</origin>
  <state>Solid</state>
  <logp>2.8</logp>
  <hmdb-id nil="true"/>
  <chembl-id nil="true"/>
  <chemspider-id nil="true"/>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference></synthesis-reference>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM001471</chemdb-id>
  <dsstox-id>DTXSID6020195</dsstox-id>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id>NS00076351</susdat-id>
  <iupac>4a-ethyl-9-methoxy-3,4,5,10,11,11a-hexahydro-1H-pyrido[2,3-b]carbazol-2-one</iupac>
  <moldb-polar-surface-area>57.199999999999996</moldb-polar-surface-area>
  <moldb-refractivity>13.0639</moldb-refractivity>
  <moldb-polarizability>5.753740264052536</moldb-polarizability>
  <moldb-rotatable-bond-count>0</moldb-rotatable-bond-count>
  <moldb-acceptor-count>3</moldb-acceptor-count>
  <moldb-donor-count>0</moldb-donor-count>
  <moldb-pka-strongest-acidic>-29.82074684950307</moldb-pka-strongest-acidic>
  <moldb-pka-strongest-basic nil="true"/>
  <moldb-physiological-charge>-1</moldb-physiological-charge>
  <moldb-number-of-rings>0</moldb-number-of-rings>
  <moldb-alogps-logp nil="true"/>
  <moldb-alogps-logs nil="true"/>
  <moldb-alogps-solubility nil="true"/>
  <kingdom>Inorganic compounds</kingdom>
  <superklass>Mixed metal/non-metal compounds</superklass>
  <klass>Alkali metal oxoanionic compounds</klass>
  <subklass>Alkali metal bromates</subklass>
  <paper-count type="integer">525</paper-count>
  <sync-id>CED0008025</sync-id>
  <structure-inchikey>YKMIIXZZCULMJS-UHFFFAOYSA-N</structure-inchikey>
  <structure-fingerprint>400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000800000000000000000000000000000000000000000000000001000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000400000000000000000000000000000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000</structure-fingerprint>
  <structure-pattern-fingerprint>200000000004000000000040000000000000000000000000000000000000000000000000000400000000400000000000000000000000000000000000004200000000000000000002000000000000000000040000000000000000000040000000000000000000000001000000001000020040000004000000000000002000000010000002400000000000080000000000204020000000000000000800000000000040000000000000002000000000000000000000040000000000000000000000000000000000400000000000000000000000000000000000000000000000000000000000004000000000000010000000</structure-pattern-fingerprint>
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  <structure-indexed-at type="dateTime">2026-09-19T04:00:10Z</structure-indexed-at>
</compound>
