1995 2,2',3,3',4,4',5',6-Octabromobiphenyl 2,2',3,3',4,4',5',6-Octabromobiphenyl belongs to the biphenyls and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. With an average molecular weight of 785.38 g/mol, 2,2',3,3',4,4',5',6-Octabromobiphenyl is a heavy molecule. This exogenous compound has the formula C12H2Br8 and exists as a solid at room temperature. It acts on the aryl hydrocarbon receptor (AHR), which it binds to and activates. This process initiates the transcriptional upregulation of several genes, including the cytochrome P-450-dependent monooxygenases CYP1A1 and CYP1A2. Such activity affects cell cycle regulation, oxidative stress response, morphogenesis, and biochemical and endocrine pathways, resulting in toxic responses. 69278-61-1 155279 C12H2Br8 777.362350 Colorless to white powder. Oral (L628) ; inhalation (L628) ; dermal (L628) The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR). PBBs bind to and activate the AhR, which in turn initiates the transcriptional upregulation of a number of genes, affecting biochemical and endocrine pathways, cell cycle regulation, morphogenesis, oxidative stress response, and various other processes. This results in the numerous toxic responses characteristic of PBBs. Some of the known induced genes include the cytochrome P-450-dependent monooxygenases CYP1A1 and CYP1A2. (L628) PBBs can be absorbed via oral, inhalation, and dermal routes. Due to their lipophilic nature, PBBs, especially the highly brominated congeners, tend to accumulate in lipid-rich tissues such as the liver, adipose, skin, and breast milk. Certain PBB compounds are metabolized by the microsomal monooxygenase system catalyzed by cytochrome P-450 of the type induced by phenobarbital. The rate of metabolism may depends on the bromine substitution pattern. PBB congeners of low bromine content are transformed into hydroxylated derivatives that are predominately eliminated in the urine. Highly brominated congeners are either retained or excreted unchanged in the feces. (L628) 2A, probably carcinogenic to humans. (L135) PBBs can be used as flame retardants and may be added to the plastics used to make products like computer monitors, televisions, textiles, and plastic foams to make them difficult to burn. However, the use of PBBs is banned or restricted in most areas due to their toxicity and persistence in the environment. (L628, L629) Acute Oral: 0.01 mg/kg/day (L134) PBB exposure may cause weight loss, skin disorders (such as acne), nervous and immune systems effects, and effects on the liver, kidneys, and thyroid gland. (L628) Symptoms of PBB exposure may include nausea, abdominal pain, loss of appetite, joint pain, fatigue, and weakness. (L629) EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. 2009-06-24T17:05:49Z 2026-08-27T22:05:58Z 2,2',3,3',4,4',5',6-Octabromobiphenyl true BrC1=CC(Br)=C(C(Br)=C1Br)C1=CC(Br)=C(Br)C(Br)=C1Br C12H2Br8 InChI=1S/C12H2Br8/c13-4-2-6(15)9(17)11(19)7(4)3-1-5(14)10(18)12(20)8(3)16/h1-2H MOIDFYBXINJWHO-UHFFFAOYSA-N 785.376 777.36235124 Exogenous Solid 9.1 136789 CHEM001738 NS00123528 1,2,3,4-tetrabromo-5-(2,3,4,6-tetrabromophenyl)benzene 0 112.17660000000001 44.146638399819 0 0 0 0 2 7.39 -7.36 3.40e-05 g/l Organic compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives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 776t3gAAAAAQAAAAAwAAAAAAAAAUAAAAFQAAAIABIwAgAAAAAQZAKAAAAAME BkBoAAAAAwMBBkAoAAAAAwQjACAAAAABBkAoAAAAAwQGQCgAAAADBCMAIAAA AAEGQCgAAAADBCMAIAAAAAEGQCgAAAADBAZAaAAAAAMDAQZAKAAAAAMEIwAg AAAAAQZAKAAAAAMEIwAgAAAAAQZAKAAAAAMEIwAgAAAAAQZAKAAAAAMEIwAg AAAAAQsAAQABAmgMAgNoDAMEAAMFaAwFBmgMBgcABghoDAgJAAUKIAoLaAwL DGgMDA0ADA5oDA4PAA4QaAwQEQAQEmgMEhMACAFoDBIKaAxCAgAAAAYBCAYF AwIGCwwOEBIKFwQAAAAAAAAAFg== 2026-09-19T04:00:19Z