2143 1,2,3,4,6,8,9-Heptachlorodibenzofuran 1,2,3,4,6,8,9-Heptachlorodibenzofuran belongs to the dibenzofurans, a subclass of benzofurans within the organic compounds. This exogenous organoheterocyclic compound has the formula C12HCl7O and an average molecular weight of 409.31 g/mol. At room temperature, it exists as a solid. Recorded protein targets for this compound include the transient receptor potential cation channel subfamily A member 1 (TRPA1) and the aryl hydrocarbon receptor (AHR). Binding to the aryl hydrocarbon receptor increases its ability to activate transcription in the XRE promoter region, which alters the expression of several genes. 69698-58-4 50611 C12HCl7O 405.784710 Colorless crystals. Inhalation (L952) ; dermal (L952) ; oral (L952) Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic resoponse element) promoter region. Specifically AhR binds to the PCDF, translocates it to the nucleus and together with hydrocarbon nuclear translocator (ARNT) and xenobiotic responsive element (XRE) increases the expression of CYP1A1 and aryl hydrocarbon hydroxylase (CYP1B1). AhR signaling also increseases conversion of arachidonic acid to prostanoids via cyclooxygenase-2, alters Wnt/beta-catenin signaling downregulating Sox9 and alters signaling by receptors for inflammatory cytokines. AhR signalling also alters proteasomal degradation of steroid hormone receptors, alters cellular UVB stress response and changes the differentiation of certain T-cell subsets. The resulting AhR mediated activation and alteration leads to body weight loss, cancer and thymic atrophy (characteristic of immune and endocrine disruption) which are common toxic responses to PCDFs and related toxic halogenated aryl hydrocarbons. No information on the metabolism of dibenzofuran in mammalian organisms was found in the available literature. The bacteria Sphingomonas, Brevibacterium, Terrabacter, and Staphylococcus auricularis degrade dibenzofuran to 2,2',3-trihydroxybiphenyl via dibenzofuran 4,4a-dioxygenase. (L952) 3, not classifiable as to its carcinogenicity to humans. (L135) CDFs are created from production of coal tar and during incineration. They are used as insecticides, in the production of PVC, and in industrial bleaching. (L952) CDFs cause vomiting and diarrhea, anemia, more frequent lung infections, numbness and other effects on the nervous system, and mild changes in the liver. However, there were no permanent liver changes or definite liver damage found in people who ingested CDFs. (L952) Skin and eye irritations, especially severe acne, darkened skin color, and swollen eyelids with discharge are the most obvious health effects of the CDF poisoning. (L952) 2009-06-24T20:57:44Z 2026-08-18T22:15:30Z 1,2,3,4,6,8,9-Heptachlorodibenzofuran true ClC1=C2OC3=C(Cl)C(Cl)=C(Cl)C(Cl)=C3C2=C(Cl)C(Cl)=C1 C12HCl7O InChI=1S/C12HCl7O/c13-2-1-3(14)11-4(6(2)15)5-7(16)8(17)9(18)10(19)12(5)20-11/h1H BADFHCOLISGRRW-UHFFFAOYSA-N 409.307 405.784708603 Exogenous Solid 7.6 45874 CHEM001867 NS00120306 1,2,3,4,6,8,9-heptachlorodibenzofuran 13.14 84.86039999999998 34.03411209177651 0 0 0 -4.234735129337839 0 3 7.63 -5.58 1.09e-03 g/l Organic compounds Organoheterocyclic compounds Benzofurans Dibenzofurans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 776t3gAAAAAQAAAAAwAAAAAAAAAUAAAAFgAAAIABEQAgAAAAAQZAKAAAAAME BkAoAAAAAwQIQCgAAAADAgZAKAAAAAMEBkAoAAAAAwQRACAAAAABBkAoAAAA AwQRACAAAAABBkAoAAAAAwQRACAAAAABBkAoAAAAAwQRACAAAAABBkAoAAAA AwQGQCgAAAADBAZAKAAAAAMEEQAgAAAAAQZAKAAAAAMEEQAgAAAAAQZAaAAA AAMDAQsAAQABAmgMAgNoDAMEaAwEBWgMBQYABQdoDAcIAAcJaAwJCgAJC2gM CwwACw1oDA0OaAwOD2gMDxAADxFoDBESABETaAwTAWgMDgJoDA0EaAxCAwAA AAYBExEPDgIFAwIODQQGBQcJCw0EFwQAAAAAAAAAFg== 2026-09-19T04:00:22Z