2286 3,7-Dichlorodibenzofuran 3,7-Dichlorodibenzofuran (C12H6Cl2O) is an exogenous organic compound with an average molecular weight of 237.08 g/mol. It exists as a solid at room temperature. 3,7-Dichlorodibenzofuran belongs to the dibenzofurans, a subclass of benzofurans within the organic compounds. The compound has two recorded protein targets. It binds to the aryl hydrocarbon receptor (AHR), which increases its ability to activate transcription in the XRE promoter region and alters the expression of several genes. Additionally, it targets the transient receptor potential cation channel subfamily A member 1 (TRPA1). 58802-21-4 42846 C12H6Cl2O 235.979570 Colorless crystals. Inhalation (L952) ; dermal (L952) ; oral (L952) Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic resoponse element) promoter region. Specifically AhR binds to the PCDF, translocates it to the nucleus and together with hydrocarbon nuclear translocator (ARNT) and xenobiotic responsive element (XRE) increases the expression of CYP1A1 and aryl hydrocarbon hydroxylase (CYP1B1). AhR signaling also increseases conversion of arachidonic acid to prostanoids via cyclooxygenase-2, alters Wnt/beta-catenin signaling downregulating Sox9 and alters signaling by receptors for inflammatory cytokines. AhR signalling also alters proteasomal degradation of steroid hormone receptors, alters cellular UVB stress response and changes the differentiation of certain T-cell subsets. The resulting AhR mediated activation and alteration leads to body weight loss, cancer and thymic atrophy (characteristic of immune and endocrine disruption) which are common toxic responses to PCDFs and related toxic halogenated aryl hydrocarbons. No information on the metabolism of dibenzofuran in mammalian organisms was found in the available literature. The bacteria Sphingomonas, Brevibacterium, Terrabacter, and Staphylococcus auricularis degrade dibenzofuran to 2,2',3-trihydroxybiphenyl via dibenzofuran 4,4a-dioxygenase. (L952) 3, not classifiable as to its carcinogenicity to humans. (L135) CDFs are created from production of coal tar and during incineration. They are used as insecticides, in the production of PVC, and in industrial bleaching. (L952) CDFs cause vomiting and diarrhea, anemia, more frequent lung infections, numbness and other effects on the nervous system, and mild changes in the liver. However, there were no permanent liver changes or definite liver damage found in people who ingested CDFs. (L952) Skin and eye irritations, especially severe acne, darkened skin color, and swollen eyelids with discharge are the most obvious health effects of the CDF poisoning. (L952) 2009-06-24T20:58:18Z 2026-08-18T21:16:05Z 3,7-Dichlorodibenzofuran true ClC1=CC=C2C(OC3=CC(Cl)=CC=C23)=C1 C12H6Cl2O InChI=1S/C12H6Cl2O/c13-7-1-3-9-10-4-2-8(14)6-12(10)15-11(9)5-7/h1-6H OLTYAGNRSNFHLK-UHFFFAOYSA-N 237.081 235.979570228 Exogenous Solid 4.9 39080 CHEM001971 NS00124099 3,7-dichlorodibenzofuran 13.14 60.83640000000002 23.311802419907355 0 0 0 -3.7956517147068065 0 3 5.31 -4.42 9.03e-03 g/l Organic compounds Organoheterocyclic compounds Benzofurans Dibenzofurans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 776t3gAAAAAQAAAAAwAAAAAAAAAPAAAAEQAAAIABEQAgAAAAAQZAKAAAAAME BkBoAAAAAwMBBkBoAAAAAwMBBkAoAAAAAwQGQCgAAAADBAhAKAAAAAMCBkAo AAAAAwQGQGgAAAADAwEGQCgAAAADBBEAIAAAAAEGQGgAAAADAwEGQGgAAAAD AwEGQCgAAAADBAZAaAAAAAMDAQsAAQABAmgMAgNoDAMEaAwEBWgMBQZoDAYH aAwHCGgMCAloDAkKAAkLaAwLDGgMDA1oDAUOaAwOAWgMDQRoDA0HaAxCAwAA AAYBDgUEAwIFBgUEDQcGCAkLDA0HFwQAAAAAAAAAFg== 2026-09-19T04:00:26Z