2509 Prophalloin Prophalloin is a solid compound of exogenous origin with the formula C35H48N8O9S. Prophalloin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 756.87 g/mol, Prophalloin is a heavy molecule. This compound targets four specific proteins: cytoplasmic 1 actin (ACTB), cytoplasmic 2 actin (ACTG1), alpha skeletal muscle actin (ACTA1), and aortic smooth muscle actin (ACTA2). Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent subunits together. This mechanism leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization. Moreover, they inhibit the ATP hydrolysis activity of F-actin. 67739-84-8 155035 C35H48N8O9S 756.86882 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent subunits together. This leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization. Moreover, they inhibit the ATP hydrolysis activity of F-actin. (L1183, A2465) LD50: >20 mg/kg (Mouse) (T258) No indication of carcinogenicity to humans (not listed by IARC). Phalloidin is one of a group of toxins from the death cap (Amanita phalloides) known as phallotoxins. (L996) Liver lesions, tachycardia, hypoglycemia, hypotension and electrolyte imbalance with acid- base disturbance (L1160). Hypovolemic shock; Gastrointestinal symptoms occur after a latent period and include abdominal pain, vomiting, and watery diarrhea. Neurologic symptoms are related to hepatic failure and may include encephalopathy, somnolence, confusion, coma and seizures (L1160). Consider gastric lavage and activated charcoal. (A678) 2009-07-03T21:46:55Z 2026-08-31T20:54:25Z Prophalloin true CC(O)C1N=C(O)C(C)N=C(O)C(CC(C)(C)O)N=C(O)C2CC3=C(NC4=CC=CC=C34)SCC(N=C1O)C(=O)N1CCCC1C(O)=NC(C)C(O)=N2 C35H48N8O9S InChI=1S/C35H48N8O9S/c1-16-27(45)38-22-13-20-19-9-6-7-10-21(19)41-33(20)53-15-24(34(51)43-12-8-11-25(43)31(49)37-16)40-32(50)26(18(3)44)42-28(46)17(2)36-30(48)23(39-29(22)47)14-35(4,5)52/h6-7,9-10,16-18,22-26,41,44,52H,8,11-15H2,1-5H3,(H,36,48)(H,37,49)(H,38,45)(H,39,47)(H,40,50)(H,42,46) VXROMVCOGJAUJL-UHFFFAOYSA-N 756.869 756.326495864 Exogenous Solid 0.4 136585 CHEM002054 NS00126184 34-(1-hydroxyethyl)-28-(2-hydroxy-2-methylpropyl)-23,31-dimethyl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone 272.09999999999997 194.53300000000002 77.82412219279004 3 15 9 -6.511189875682057 14.96284177199049 0 5 1.17 -3.80 1.19e-01 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 0 CED0042839 VXROMVCOGJAUJL-UHFFFAOYSA-N 44000000000000020000800000202100000000044000000000000000110000000002001080000020000010000040002000800000000000020000000800000004000000000000000000000000000000200220000010090000001000000010000000000000010000000080010000000000000008020100000000002000020000100800000040000080c00000200000000000000000000100000000000020000000000410048004400000040000081010000000000000000000018000000000001000000000040000002004090000200000002008000000000040004200000001000000000008000000000040000000080000000000000400400000200000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAA1AAAAOQAAAIABBgBgAAAAAQMGAGAAAAAD AQgAYAAAAAEBBgBgAAAAAwEHACgAAAADAwYAKAAAAAMECABoAAAAAwEBBgBg AAAAAwEGAGAAAAABAwcAKAAAAAMDBgAoAAAAAwQIAGgAAAADAQEGAGAAAAAD AQYAYAAAAAICBgAgAAAABAYAYAAAAAEDBgBgAAAAAQMIAGAAAAABAQcAKAAA AAMDBgAoAAAAAwQIAGgAAAADAQEGAGAAAAADAQYAYAAAAAICBkAoAAAAAwQG QCgAAAADBAdAOAAAAAMBAwZAKAAAAAMEBkBoAAAAAwMBBkBoAAAAAwMBBkBo AAAAAwMBBkBoAAAAAwMBBkAoAAAAAwQQACAAAAACBgBgAAAAAgIGAGAAAAAD AQcAKAAAAAMDBgAoAAAAAwQIAGgAAAADAQEGACgAAAADBAgAKAAAAAMCBwAo AAAAAwMGAGAAAAACAgYAYAAAAAICBgBgAAAAAgIGAGAAAAADAQYAKAAAAAME CABoAAAAAwEBBwAoAAAAAwMGAGAAAAADAQYAYAAAAAEDBgAoAAAAAwQIAGgA AAADAQEHACgAAAADAwsAAQABAgABAwADBAAEBSgCBQYgBQcABwgABwkACQoo AgoLIAoMAAwNAA0OAA4PAA4QAA4RAAwSABITKAITFCATFQAVFgAWFwAXGGgM GBloDBkaaAwaG2gMGxxoDBwdaAwdHmgMHh9oDBggACAhACEiACIjACMkKAIk JSAiJgAmJygCJiggKCkAKSoAKisAKywALC0ALS4gLS8oAi8wADAxADAyADIz IDI0KAIkAwAsKAA0FQAfF2gMHxpoDEIFAAAAEgMkIyIhIBgXFhUTEgwKCQcF BA8WFTQyMC8tLCgmIiEgGBcFGRgXHxoGGxwdHh8aBSkoLCsqFwQAAAAAAAAA Fg== 2026-09-19T04:00:28Z