2510 Phalloin Phalloin is a solid exogenous compound with the chemical formula C35H48N8O10S. Phalloin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 772.87 g/mol, Phalloin is a heavy molecule. This compound targets four proteins: cytoplasmic 1 actin (ACTB), cytoplasmic 2 actin (ACTG1), alpha skeletal muscle actin (ACTA1), and aortic smooth muscle actin (ACTA2). Phallotoxins bind actin at the interface between F-actin subunits, locking adjacent subunits together and preventing depolymerization, which poisons the cell. This mechanism leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, essentially stabilizing actin filaments. Additionally, these toxins inhibit the ATP hydrolysis activity of F-actin. Phalloin is one of a group of toxins known as phallotoxins isolated from the death cap (Amanita phalloides). The phallotoxins consist of at least seven compounds, all of which have seven similar peptide rings. 28227-92-1 34183 C35H48N8O10S 772.86822 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent subunits together. This leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization. Moreover, they inhibit the ATP hydrolysis activity of F-actin. (L1183, A2465) LD50: 1.5 mg/kg (Mouse) (T258) No indication of carcinogenicity to humans (not listed by IARC). Prophalloin is one of a group of toxins from the death cap (Amanita phalloides) known as phallotoxins. (L996) Liver lesions, tachycardia, hypoglycemia, hypotension and electrolyte imbalance with acid- base disturbance (L1160). Hypovolemic shock; Gastrointestinal symptoms occur after a latent period and include abdominal pain, vomiting, and watery diarrhea. Neurologic symptoms are related to hepatic failure and may include encephalopathy, somnolence, confusion, coma and seizures (L1160). Consider gastric lavage and activated charcoal. (A678) 2009-07-03T21:46:55Z 2026-08-22T11:47:18Z C024287 Phalloin true CC(O)C1N=C(O)C(C)N=C(O)C(CC(C)(C)O)N=C(O)C2CC3=C(NC4=CC=CC=C34)SCC(N=C1O)C(=O)N1CC(O)CC1C(O)=NC(C)C(O)=N2 C35H48N8O10S InChI=1S/C35H48N8O10S/c1-15-27(46)38-22-11-20-19-8-6-7-9-21(19)41-33(20)54-14-24(34(52)43-13-18(45)10-25(43)31(50)37-15)40-32(51)26(17(3)44)42-28(47)16(2)36-30(49)23(39-29(22)48)12-35(4,5)53/h6-9,15-18,22-26,41,44-45,53H,10-14H2,1-5H3,(H,36,49)(H,37,50)(H,38,46)(H,39,48)(H,40,51)(H,42,47) VVAHMTWEOWYEHQ-UHFFFAOYSA-N 772.868 772.321410486 Exogenous Solid -0.6 31503 CHEM002055 NS00126146 18-hydroxy-34-(1-hydroxyethyl)-28-(2-hydroxy-2-methylpropyl)-23,31-dimethyl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone 292.33 195.85090000000005 76.35288755446592 3 16 10 -6.510362196395175 14.963813529172828 0 5 0.69 -3.67 1.64e-01 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 22 CED0025678 VVAHMTWEOWYEHQ-UHFFFAOYSA-N 44200000000000020000800000202100000000044000000000000000110000000002001080000020000010000040002000800000000000000000000800000004000000000000000000020000000000000220000010090000001000001000000000000000010000000080010000000000000008020100000000002000020000100000000040000080c00000200000000000000000000100000000000020400000000c10048020400000040000081010000000000000000000010000000000000000000000040000002004090008200000002008000000000040004200000001000000000008000000000040000000080000000000008400400000200000000000 7006c0508d33c620c9dcd36783f8b2889900349a9517a074cd3c60d0ca30eacc6c7600d913a0204c0540412800c0200097680b25c08e723503cf7f7dc0a24124c711948d1ad01400c09012401a732a604844c59151611fb752544d6654221bb7cd68656f184c3220609a9184ddf40044708690f28991e506b17b2e79835119175044181d5ef8a60a0c1f03d0ee2c42a8393cda1245c2be8b50320ca060d8478451d310d309b6d2330b866d68857c3d144ac12243a9418a4818b14ab4cc624a12a21110a7bdd913331dc006a6575542990c316014032578628d70f60e2e01030491386d3618c94b2c1b6c2411db56a88e1e5026b092c6042f539993805a0e0c46 776t3gAAAAAQAAAAAwAAAAAAAAA2AAAAOgAAAIABBgBgAAAAAQMGAGAAAAAD AQgAYAAAAAEBBgBgAAAAAwEHACgAAAADAwYAKAAAAAMECABoAAAAAwEBBgBg AAAAAwEGAGAAAAABAwcAKAAAAAMDBgAoAAAAAwQIAGgAAAADAQEGAGAAAAAD AQYAYAAAAAICBgAgAAAABAYAYAAAAAEDBgBgAAAAAQMIAGAAAAABAQcAKAAA AAMDBgAoAAAAAwQIAGgAAAADAQEGAGAAAAADAQYAYAAAAAICBkAoAAAAAwQG QCgAAAADBAdAOAAAAAMBAwZAKAAAAAMEBkBoAAAAAwMBBkBoAAAAAwMBBkBo AAAAAwMBBkBoAAAAAwMBBkAoAAAAAwQQACAAAAACBgBgAAAAAgIGAGAAAAAD AQcAKAAAAAMDBgAoAAAAAwQIAGgAAAADAQEGACgAAAADBAgAKAAAAAMCBwAo AAAAAwMGAGAAAAACAgYAYAAAAAMBCABgAAAAAQEGAGAAAAACAgYAYAAAAAMB BgAoAAAAAwQIAGgAAAADAQEHACgAAAADAwYAYAAAAAMBBgBgAAAAAQMGACgA AAADBAgAaAAAAAMBAQcAKAAAAAMDCwABAAECAAEDAAMEAAQFKAIFBiAFBwAH CAAHCQAJCigCCgsgCgwADA0ADQ4ADg8ADhAADhEADBIAEhMoAhMUIBMVABUW ABYXABcYaAwYGWgMGRpoDBobaAwbHGgMHB1oDB0eaAweH2gMGCAAICEAISIA IiMAIyQoAiQlICImACYnKAImKCAoKQApKgAqKwAqLAAsLQAtLgAuLyAuMCgC MDEAMTIAMTMAMzQgMzUoAiQDAC0oADUVAB8XaAwfGmgMQgUAAAASAyQjIiEg GBcWFRMSDAoJBwUEDxYVNTMxMC4tKCYiISAYFwUZGBcfGgYbHB0eHxoFKSgt LCoXBAAAAAAAAAAW 2026-09-19T04:00:28Z