2511 Phallisin Phallisin is a solid compound with the formula C35H48N8O12S. Phallisin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 804.87 g/mol, Phallisin is a heavy molecule. It is an exogenous substance and is one of a group of toxins known as phallotoxins from the death cap (Amanita phalloides). The phallotoxins consist of at least seven compounds, all of which have seven similar peptide rings, isolated from the death cap (Amanita phalloides). The protein targets of Phallisin include Actin, cytoplasmic 1 (ACTB), Actin, cytoplasmic 2 (ACTG1), Actin, alpha skeletal muscle (ACTA1), and Actin, aortic smooth muscle (ACTA2). Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent subunits together. This leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization. Moreover, they inhibit the ATP hydrolysis activity of F-actin. 19774-69-7 115286 C35H48N8O12S 804.86702 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent subunits together. This leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization. Moreover, they inhibit the ATP hydrolysis activity of F-actin. (L1183, A2465) LD50: 2 mg/kg (Mouse) (T258) No indication of carcinogenicity to humans (not listed by IARC). Phalloin is one of a group of toxins from the death cap (Amanita phalloides) known as phallotoxins. (L996) Liver lesions, tachycardia, hypoglycemia, hypotension and electrolyte imbalance with acid- base disturbance (L1160). Hypovolemic shock; Gastrointestinal symptoms occur after a latent period and include abdominal pain, vomiting, and watery diarrhea. Neurologic symptoms are related to hepatic failure and may include encephalopathy, somnolence, confusion, coma and seizures (L1160). Consider gastric lavage and activated charcoal. (A678) 2009-07-03T21:46:56Z 2026-04-06T13:07:55Z C014739 Phallisin true CC(O)C1N=C(O)C(C)N=C(O)C(CC(O)(CO)CO)N=C(O)C2CC3=C(NC4=CC=CC=C34)SCC(N=C1O)C(=O)N1CC(O)CC1C(O)=NC(C)C(O)=N2 C35H48N8O12S InChI=1S/C35H48N8O12S/c1-15-27(48)38-22-9-20-19-6-4-5-7-21(19)41-33(20)56-12-24(34(54)43-11-18(47)8-25(43)31(52)37-15)40-32(53)26(17(3)46)42-28(49)16(2)36-30(51)23(39-29(22)50)10-35(55,13-44)14-45/h4-7,15-18,22-26,41,44-47,55H,8-14H2,1-3H3,(H,36,51)(H,37,52)(H,38,48)(H,39,50)(H,40,53)(H,42,49) SRDQDZSLNAKOIT-UHFFFAOYSA-N 804.867 804.31123973 Exogenous Solid 103147 CHEM002056 NS00125401 332.78999999999996 198.93830000000005 78.08919954417352 5 18 12 -6.582786858337228 15.000000007987648 0 5 -0.14 -3.73 1.51e-01 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 7 CED0032232 SRDQDZSLNAKOIT-UHFFFAOYSA-N 44200000000000020000800000203100000000044000000000000002110000001002001080000020000010000040002000000000000000000000000800000004000000000000000000020000000000000220000010090000001000001200000000000000010000000080000000000000000008020100000000002000020000100000000040000080c00000200000000000000000000100000000000020400000008c10048020000000040000081010000000000000000000010000000000000000000000040000002004090008000000002008000000000040004200000001000000000008000000000040000000080001000000008400400000200000000000 7006c0508d33c620c9dcd36783f8b288990034ba9517a074cd3c60d4ca30eacc6c7600d913a0204c8540412800c0200097680b25c08e723503cf7f7dc0a24124c711948d1ad01400c09012c01a732a604844c59151611fb752544d6654221bb7cd68656f184c3220609a9184ddf40044708692f28991e586b17b2e79835119175044181d5ef8a60a0c1f03d0ee2c42a8393cda1245c2be8b70320ca060d8478451d310d309b6d2330b866d68877c3d144ac12243a9418ac818b14ab4cc624a12a21110a7bddb53331dc006a6575542990c356014032578628d70f60e2e01030491386d3618c94b2c1b6c2411db56a88e1e5026b492c6842f53999b80da0e0c46 776t3gAAAAAQAAAAAwAAAAAAAAA4AAAAPAAAAIABBgBgAAAAAQMGAGAAAAAD AQgAYAAAAAEBBgBgAAAAAwEHACgAAAADAwYAKAAAAAMECABoAAAAAwEBBgBg AAAAAwEGAGAAAAABAwcAKAAAAAMDBgAoAAAAAwQIAGgAAAADAQEGAGAAAAAD AQYAYAAAAAICBgAgAAAABAgAYAAAAAEBBgBgAAAAAgIIAGAAAAABAQYAYAAA AAICCABgAAAAAQEHACgAAAADAwYAKAAAAAMECABoAAAAAwEBBgBgAAAAAwEG AGAAAAACAgZAKAAAAAMEBkAoAAAAAwQHQDgAAAADAQMGQCgAAAADBAZAaAAA AAMDAQZAaAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMDAQZAKAAAAAMEEAAgAAAA AgYAYAAAAAICBgBgAAAAAwEHACgAAAADAwYAKAAAAAMECABoAAAAAwEBBgAo AAAAAwQIACgAAAADAgcAKAAAAAMDBgBgAAAAAgIGAGAAAAADAQgAYAAAAAEB BgBgAAAAAgIGAGAAAAADAQYAKAAAAAMECABoAAAAAwEBBwAoAAAAAwMGAGAA AAADAQYAYAAAAAEDBgAoAAAAAwQIAGgAAAADAQEHACgAAAADAwsAAQABAgAB AwADBAAEBSgCBQYgBQcABwgABwkACQooAgoLIAoMAAwNAA0OAA4PAA4QABAR AA4SABITAAwUABQVKAIVFiAVFwAXGAAYGQAZGmgMGhtoDBscaAwcHWgMHR5o DB4faAwfIGgMICFoDBoiACIjACMkACQlACUmKAImJyAkKAAoKSgCKCogKisA KywALC0ALC4ALi8ALzAAMDEgMDIoAjIzADM0ADM1ADU2IDU3KAImAwAvKgA3 FwAhGWgMIRxoDEIFAAAAEgMmJSQjIhoZGBcVFAwKCQcFBA8YFzc1MzIwLyoo JCMiGhkFGxoZIRwGHR4fICEcBSsqLy4sFwQAAAAAAAAAFg== 2026-09-19T04:00:28Z