2513 Phallacin Phallacin is a solid compound with the formula C37H50N8O12S. Phallacin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 830.90 g/mol, Phallacin is a heavy molecule. It is an exogenous substance and is one of a group of toxins known as phallotoxins isolated from the death cap (Amanita phalloides). The phallotoxins consist of at least seven compounds, all of which have seven similar peptide rings. Phallacin targets four specific proteins: ACTB (Actin, cytoplasmic 1), ACTG1 (Actin, cytoplasmic 2), ACTA1 (Actin, alpha skeletal muscle), and ACTA2 (Actin, aortic smooth muscle). Phallotoxins bind specifically at the interface between F-actin subunits, locking adjacent subunits together and preventing depolymerization. This interaction leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments. Furthermore, phallotoxins inhibit the ATP hydrolysis activity of F-actin, ultimately poisoning the cell. 53568-40-4 171277 C37H50N8O12S 830.9043 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent subunits together. This leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization. Moreover, they inhibit the ATP hydrolysis activity of F-actin. (L1183, A2465) LD50: 1.5 mg/kg (Mouse) (T258) No indication of carcinogenicity to humans (not listed by IARC). Phallacidin is one of a group of toxins from the death cap (Amanita phalloides) known as phallotoxins. (L996) Liver lesions, tachycardia, hypoglycemia, hypotension and electrolyte imbalance with acid- base disturbance (L1160). Hypovolemic shock; Gastrointestinal symptoms occur after a latent period and include abdominal pain, vomiting, and watery diarrhea. Neurologic symptoms are related to hepatic failure and may include encephalopathy, somnolence, confusion, coma and seizures (L1160). Consider gastric lavage and activated charcoal. (A678) 2009-07-03T21:46:57Z 2026-08-31T21:59:11Z Phallacin true CC(C)C1N=C(O)C(CC(C)(C)O)N=C(O)C2CC3=C(NC4=CC=CC=C34)SCC(N=C(O)C(N=C1O)C(O)C(O)=O)C(=O)N1CC(O)CC1C(O)=NC(C)C(O)=N2 C37H50N8O12S InChI=1S/C37H50N8O12S/c1-15(2)25-32(52)44-26(27(47)36(55)56)33(53)41-23-14-58-34-19(18-8-6-7-9-20(18)42-34)11-21(29(49)40-22(30(50)43-25)12-37(4,5)57)39-28(48)16(3)38-31(51)24-10-17(46)13-45(24)35(23)54/h6-9,15-17,21-27,42,46-47,57H,10-14H2,1-5H3,(H,38,51)(H,39,48)(H,40,49)(H,41,53)(H,43,50)(H,44,52)(H,55,56) LAVFLHFIXHMDLZ-UHFFFAOYSA-N 830.904 830.326889794 Exogenous Solid -0.5 149740 CHEM002057 NS00123066 2-hydroxy-2-[18-hydroxy-28-(2-hydroxy-2-methylpropyl)-23-methyl-15,21,24,26,29,32,35-heptaoxo-31-propan-2-yl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraen-34-yl]acetic acid 329.62999999999994 206.25760000000008 82.56185117963525 5 18 11 2.3269348559850003 5.446897046969477 -1 5 0.68 -3.75 1.48e-01 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 1 CED0035781 LAVFLHFIXHMDLZ-UHFFFAOYSA-N 44200000000000020000800000202100000000044000000000000000110000040002001080000020000010000060003004800000000000000000000800000000000000000000000000020000000000000020000010080000001000001000000000000000010000000080010000001000000008020100000000002000020000100000000040000080c00000200000000000000010000100000000000020400000000c10048020400000040000081010000000000000000000010000000000000000000000040000002004090008200000002008000000000040004200000001000000000008000800000040000000080400000000108400400000220000000000 7006c0708d33c620c9dcd36783f8b288991034ba9517a074cd3c60d4cb30eacc6c7600d913a0204c8540412800c9200097680ba5c0ce723503cf7f7dc0e24124c711948d1ad01400c29012e01a732b604844c59151611fb753544d6654221bb7cde8656f184c3230609a9184ddf40044708692f2899de586b17b2e79835119175044181d5ef8a60a0c1f03d0ee2c42a8393cda1645c2be8b70360ca062d8478451d710d309b6d2330b866d68877c3d144ac12243a9418ac818b14ab4cc6a4a12a61110a7bddb53331dc026a6575542990c316014032578628d70f60e2e01030491386d3618c94b2d1b6c2411db56a88e1e5026b492c6842f53999b82da0e0c46 776t3gAAAAAQAAAAAwAAAAAAAAA6AAAAPgAAAIABBgBgAAAAAQMGAGAAAAAD AQYAYAAAAAEDBgBgAAAAAwEHACgAAAADAwYAKAAAAAMECABoAAAAAwEBBgBg AAAAAwEGAGAAAAACAgYAIAAAAAQGAGAAAAABAwYAYAAAAAEDCABgAAAAAQEH ACgAAAADAwYAKAAAAAMECABoAAAAAwEBBgBgAAAAAwEGAGAAAAACAgZAKAAA AAMEBkAoAAAAAwQHQDgAAAADAQMGQCgAAAADBAZAaAAAAAMDAQZAaAAAAAMD AQZAaAAAAAMDAQZAaAAAAAMDAQZAKAAAAAMEEAAgAAAAAgYAYAAAAAICBgBg AAAAAwEHACgAAAADAwYAKAAAAAMECABoAAAAAwEBBgBgAAAAAwEHACgAAAAD AwYAKAAAAAMECABoAAAAAwEBBgBgAAAAAwEIAGAAAAABAQYAKAAAAAMECABo AAAAAwEBCAAoAAAAAwIGACgAAAADBAgAKAAAAAMCBwAoAAAAAwMGAGAAAAAC AgYAYAAAAAMBCABgAAAAAQEGAGAAAAACAgYAYAAAAAMBBgAoAAAAAwQIAGgA AAADAQEHACgAAAADAwYAYAAAAAMBBgBgAAAAAQMGACgAAAADBAgAaAAAAAMB AQcAKAAAAAMDCwABAAECAAEDAAMEAAQFKAIFBiAFBwAHCAAICQAJCgAJCwAJ DAAHDQANDigCDg8gDhAAEBEAERIAEhNoDBMUaAwUFWgMFRZoDBYXaAwXGGgM GBloDBkaaAwTGwAbHAAcHQAdHgAeHygCHyAgHyEAISIAIiMoAiMkICElACUm ACUnACcoICcpKAIdKgAqKygCKiwgLC0ALS4ALi8ALjAAMDEAMTIAMjMgMjQo AjQ1ADU2ADU3ADc4IDc5KAIjAwAxLAA5EAAaEmgMGhVoDEIFAAAAEgMjIiEf Hh0cGxMSERAODQcFBA8REDk3NTQyMSwqHRwbExIFFBMSGhUGFhcYGRoVBS0s MTAuFwQAAAAAAAAAFg== 2026-09-19T04:00:28Z