2801 Protriptyline Protriptyline belongs to the dibenzocycloheptenes, a class of benzenoids within the organic compounds. This exogenous compound has the formula C19H21N and an average molecular weight of 263.38 g/mol. At room temperature, it exists as a solid. Protriptyline is used as an antidepressant and is associated with oral exposure. It is found in antidepressants, food preservation, and various household cleaning and consumer products, including tobacco smoke filters, other smoking requisites, and non-electric simulated smoking devices. It is also recorded in electrical and electronic equipment, such as radio transmission systems, antennas, and electrically stimulated smoking devices. The compound acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Its recorded protein targets include the sodium-dependent noradrenaline transporter (SLC6A2), the sodium-dependent serotonin transporter (SLC6A4), the sodium-dependent dopamine transporter (SLC6A3), and the adenosine receptor A3 (ADORA3). 438-60-8 4976 C19H21N 263.167400 White powder. 169-171°C (Protriptyline HCl) 1.04 mg/L Oral Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Route of Elimination: Cumulative urinary excretion during 16 days accounted for approximately 50% of the drug. The fecal route of excretion did not seem to be important. No indication of carcinogenicity to humans (not listed by IARC). For the treatment of depression. Protriptyline shares side effects common to all tricyclic antidepressants. The most frequent of these are dry mouth, constipation, urinary retention, increased heart rate, sedation, irritability, dizziness, decreased coordination, anxiety, blood disorders, confusion, decreased libido, dizziness, flushing, headache, impotence, insomnia, low blood pressure, nightmares, rapid or irregular heartbeat, rash, seizures, sensitivity to sunlight, stomach and intestinal problems. Other more complicated side effects include; chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; sudden numbness or weakness, especially on one side of the body; sudden headache, confusion, problems with vision, speech, or balance; hallucinations, or seizure (convulsions); easy bruising or bleeding, unusual weakness; restless muscle movements in your eyes, tongue, jaw, or neck; urinating less than usual or not at all; extreme thirst with headache, nausea, vomiting, and weakness; or feeling light-headed or fainting. Deaths may occur from overdosage with this class of drugs. Multiple drug ingestion (including alcohol) is common in deliberate tricyclic antidepressant overdose. (Wikipedia) Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia. Dry mouth, if severe to the point of causing difficulty speaking or swallowing, may be managed by dosage reduction or temporary discontinuation of the drug. Patients may also chew sugarless gum or suck on sugarless candy in order to increase the flow of saliva. Some artificial saliva products may give temporary relief. Men with prostate enlargement who take protriptyline may be especially likely to have problems with urinary retention. Symptoms include having difficulty starting a urine flow and more difficulty than usual passing urine. In most cases, urinary retention is managed with dose reduction or by switching to another type of antidepressant. In extreme cases, patients may require treatment with bethanechol, a drug that reverses this particular side effect. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity develop rapidly after tricyclic antidepressant overdose, therefore, hospital monitoring is required as soon as possible. (Wikipedia) 2009-07-21T20:26:40Z 2026-05-14T16:36:02Z Protriptyline C07408 8597 Protriptyline DB00344 true CNCCCC1C2=CC=CC=C2C=CC2=CC=CC=C12 C19H21N InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3 BWPIARFWQZKAIA-UHFFFAOYSA-N 263.3767 263.167399677 Exogenous Solid 4.7 HMDB14488 CHEMBL668 4805 CHEM002178 DTXSID0023535 NS00009004 methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-yl}propyl)amine 12.03 87.30340000000004 31.60441131093086 4 1 1 10.54323028083324 1 3 4.65 -6.06 2.31e-04 g/l Organic compounds Benzenoids Dibenzocycloheptenes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 776t3gAAAAAQAAAAAwAAAAAAAAAUAAAAFgAAAIABBgBgAAAAAQMHAGAAAAAC AQYAYAAAAAICBgBgAAAAAgIGAGAAAAACAgYAYAAAAAMBBkAoAAAAAwQGQGgA AAADAwEGQGgAAAADAwEGQGgAAAADAwEGQGgAAAADAwEGQCgAAAADBAYAaAAA AAMDAQYAaAAAAAMDAQZAKAAAAAMEBkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAA AwMBBkBoAAAAAwMBBkAoAAAAAwQLAAEAAQIAAgMAAwQABAUABQYABgdoDAcI aAwICWgMCQpoDAoLaAwLDCAMDSgCDQ4gDg9oDA8QaAwQEWgMERJoDBITaAwT BQALBmgMEw5oDEIDAAAABwUGCwwNDhMGBwgJCgsGBg8QERITDhcEAAAAAAAA ABY= 2026-09-19T04:00:33Z