2856 T3D2814 Divalproex sodium Divalproex sodium is an exogenous organic compound with the formula C16H31NaO4 and an average molecular weight of 310.40 g/mol. It exists as a solid at room temperature. Divalproex sodium belongs to the fatty acids and conjugates, a subclass of fatty acyls within the organic compounds. This substance is recorded as being found in electrical and electronic equipment antennas. Used as an anticonvulsant and antimanic drug, divalproex sodium also functions as a GABA agent. It interacts with seven protein targets, including 4-aminobutyrate aminotransferase mitochondrial (ABAT), histone deacetylase 9 (HDAC9), short/branched chain specific acyl-CoA dehydrogenase mitochondrial (ACADSB), 2-oxoglutarate dehydrogenase complex component E1 (OGDH), succinate-semialdehyde dehydrogenase mitochondrial (ALDH5A1), and two other proteins. The compound binds to and inhibits GABA transaminase. Its anticonvulsant activity may be linked to increased concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system, by blocking the reuptake of GABA into nerve endings and glia or by inhibiting enzymes that catabolize GABA. Additionally, divalproex sodium may work by inhibiting voltage-sensitive sodium channels to suppress repetitive neuronal firing. 76584-70-8 53519 C16H31NaO4 310.212000 White powder. 222°C Slightly soluble (2000 mg/L) Oral Divalproex binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Divalproex is metabolized almost entirely by the liver. Mitochondrial &szlig;-oxidation is the other major metabolic pathway, typically accounting for over 40% of the dose. Fatalities have been reported; however patients have recovered from divalproex levels as high as 2120 ug/mL. (A308) No indication of carcinogenicity to humans (not listed by IARC). May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease. Overdosage with divalproex may result in somnolence,heart block,and deep coma. Fatalities have been reported; however patients have recovered from divalproex levels as high as 2120 &micro;g/mL. In overdose situations, the fraction of drug not bound to protein is high and hemodialysis or tandem hemodialysis plus hemoperfusion may result in significant removal of drug. The benefit of gastric lavage or emesis will vary with the time since ingestion. General supportive measures should be applied with particular attention to the maintenance of adequate urinary output. (L1712) 2009-07-21T20:27:04Z 2026-05-21T16:37:04Z http://en.wikipedia.org/wiki/Divalproex_sodium Divalproex sodium DB00313 true [Na+].CCCC(CCC)C(O)=O.CCCC(CCC)C([O-])=O C16H31NaO4 InChI=1S/2C8H16O2.Na/c2*1-3-5-7(6-4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+1/p-1 MSRILKIQRXUYCT-UHFFFAOYSA-M 310.4047 310.212004155 Exogenous Solid <p>Daniel Aubert, Francis Blanc, Henri Desmolin, Michel Morre, Lucette Sindely, &#8220;Valproic acid preparations.&#8221; U.S. Patent US5017613, issued January, 1965.</p> CHEM002214 DTXSID70227388 NS00076381 37.3 40.249100000000006 17.017829389405524 10 2 1 5.144389811177235 -1 0 Organic compounds Lipids and lipid-like molecules Fatty Acyls Fatty acids and conjugates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 776t3gAAAAAQAAAAAwAAAAAAAAAVAAAAEgAAAIABCyAKAAAAAQEGAGAAAAAB AwYAYAAAAAICBgBgAAAAAgIGAGAAAAADAQYAYAAAAAICBgBgAAAAAgIGAGAA AAABAwYAKAAAAAMECABoAAAAAwEBCAAoAAAAAwIGAGAAAAABAwYAYAAAAAIC BgBgAAAAAgIGAGAAAAADAQYAYAAAAAICBgBgAAAAAgIGAGAAAAABAwYAKAAA AAMECCAqAAAA/wMBCAAoAAAAAwILAQIAAgMAAwQABAUABQYABgcABAgACAkg CAooAgsMAAwNAA0OAA4PAA8QABARAA4SABITIBIUKAJCAAAAABcEAAAAAAAA ABY= 2026-09-19T04:00:35Z