2950 Progabide Progabide is an exogenous solid compound with the formula C17H16ClFN2O2 and an average molecular weight of 334.77 g/mol. Progabide belongs to the carbonyl compounds, a subclass of organooxygen compounds within the organic compounds. This compound acts on three protein targets: GABRA1, GABBR1, and GABBR2, for which it is an agonist. Progabide binds to both GABAA and GABAB receptors located on the terminals of primary afferent fibers. Binding to GABAA increases the affinity of the GABA receptor for the amino acid, augments the flux of chloride ions across the terminal membrane, and increases the amount of presynaptic inhibition. Activation of GABAB receptors retards the influx of calcium ions into the terminals, which reduces the evoked release of excitatory amino acids and possibly other transmitters. 62666-20-0 5361323 C17H16ClFN2O2 334.088430 White powder. 133-135°C 70.9 mg/L Well absorbed with a bioavailability of 60% Progabide binds to both GABA_A and GABA_B receptors located on the terminals of primary afferent fibers. Binding to GABA_A results in an increased affinity of the GABA receptor for the amino acid, an augmented flux of chloride ions across the terminal membrane, and an increase in the amount of presynaptic inhibition. Activation of the GABA_B receptors retards the influx of calcium ions into the terminals, thereby reducing the evoked release of excitatory amino acids and possibly other transmitters. Hepatic Half Life: 4 hours No indication of carcinogenicity to humans (not listed by IARC). Indicated for the treatment of epilepsy. May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease. 2009-07-21T20:27:47Z 2026-05-14T16:50:16Z Progabide Progabide DB00837 true NC(=O)CCCN\C(C1=CC=C(Cl)C=C1)=C1/C=C(F)C=CC1=O C17H16ClFN2O2 InChI=1S/C17H16ClFN2O2/c18-12-5-3-11(4-6-12)17(21-9-1-2-16(20)23)14-10-13(19)7-8-15(14)22/h3-8,10,21H,1-2,9H2,(H2,20,23)/b17-14+ DWEQWXSKOHHBNT-SAPNQHFASA-N 334.773 334.088433678 Exogenous Solid 3.06 HMDB14975 CHEMBL287631 4514729 CHEM002285 DTXSID00878140 NS00004318 4-{[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylidene]amino}butanimidic acid 72.19 91.22189999999999 33.20826964666348 6 3 2 15.315554078461773 4.014268264490627 0 2 2.68 -4.88 4.42e-03 g/l Organic compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds 251 CED0014757 DWEQWXSKOHHBNT-SAPNQHFASA-N 8800000000040008000000000020040000800000000000000080000000200000000000000000000000000000000000000000200000000000000050004000000000000000000000200010000000100000008000100000000000000100800000000000000000000000000000000000000000000000002000000000000201000000000000000000a1001000000000000000000000000000000000000000040000000000084000000000000000000000000000800000000000000008000000000000000000000000000010004000000000000200000000000000000000000080000048000020010402800000000000000000000000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAAXAAAAGAAAAIABBwBoAAAAAwECBgAoAAAA AwQIACgAAAADAgYAYAAAAAICBgBgAAAAAgIGAGAAAAACAgcAaAAAAAMCAQYA KAAAAAMEBkAoAAAAAwQGQGgAAAADAwEGQGgAAAADAwEGQCgAAAADBBEAIAAA AAEGQGgAAAADAwEGQGgAAAADAwEGACgAAAADBAYAaAAAAAMDAQYAKAAAAAME CQAgAAAAAQYAaAAAAAMDAQYAaAAAAAMDAQYAKAAAAAMECAAoAAAAAwILAAEg AQIoAgEDAAMEAAQFAAUGAAYHJAMHCCAICWgMCQpoDAoLaAwLDAALDWgMDQ5o DAcPKgIDAgYVDxAkBBARKAIREgAREyATFCgCFBUgFRYoAg4IaAwVDyBCAgAA AAYJCgsNDggGEBETFBUPFwQAAAAAAAAAFg== 2026-09-19T04:00:38Z