2961 Benzphetamine Benzphetamine is an exogenous organic compound with the formula C17H21N and an average molecular weight of 239.36 g/mol. It exists as a solid at room temperature. Benzphetamine belongs to the phenethylamines, a subclass of benzene and substituted derivatives within the organic compounds. This compound functions as a sympathomimetic agent, dopamine uptake inhibitor, and adrenergic uptake inhibitor. It is used as an appetite depressant. Its recorded protein targets include the Alpha-2A adrenergic receptor (ADRA2A), the Alpha-1A adrenergic receptor (ADRA1A), the NADPH--cytochrome P450 reductase (POR), the synaptic vesicular amine transporter (SLC18A2), and the sodium-dependent dopamine transporter (SLC6A3). Regarding its use in treating obesity, benzphetamine and related sympathomimetic medications are thought to produce a decrease in appetite by stimulating the release of dopamine and/or norepinephrine from storage sites in nerve terminals in the lateral hypothalamic feeding center. Benzphetamine has been recorded in two sources: Household cleaning & consumer products (Other Smoking Requisites) and Electrical & Electronic Equipment (Antennas). 156-08-1 5311017 C17H21N 239.167400 White powder. 129-130°C Readily soluble Oral. Readily absorbed from the gastro-intestinal tract and buccal mucosa. It Is resistant to metabolism by monoamine oxidase. Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Amphetamine and related sympathomimetic medications (such as benzphetamine) are thought to stimulate the release of norepinephrine and/or dopamine from storage sites in nerve terminals in the lateral hypothalamic feeding center, thereby producing a decrease in appetite. This release is mediated by the binding of benzphetamine to centrally located adrenergic receptors. Hepatic. Benzphetamine's metabolites include amphetamine and methamphetamine. Half Life: 16 to 31 hours LD50: 160 mg/kg (Oral, Rat) (A308) No indication of carcinogenicity to humans (not listed by IARC). For the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction Using large amounts of these drugs can result in a condition known as amphetamine psychosis -- which can result in auditory, visual and tactile hallucinations, intense paranoia, irrational thoughts and beliefs, delusions, and mental confusion. Acute overdosage may result in restlessness, tremor, tachypnea, confusion, assaultiveness, and panic states. Management of acute amphetamine intoxication is largely symptomatic and includes sedation with a barbiturate. If hypertension is marked, the use of a nitrite or rapidly acting alpha receptor blocking agent should be considered. Acidification of the urine increases amphetamine excretion. (L1712) 2009-07-21T20:27:52Z 2026-05-14T16:51:07Z Benzphetamine C07538 3044 CPD-10530 Benzphetamine DB00865 true C[C@@H](CC1=CC=CC=C1)N(C)CC1=CC=CC=C1 C17H21N InChI=1S/C17H21N/c1-15(13-16-9-5-3-6-10-16)18(2)14-17-11-7-4-8-12-17/h3-12,15H,13-14H2,1-2H3/t15-/m0/s1 YXKTVDFXDRQTKV-HNNXBMFYSA-N 239.3553 239.167399677 Exogenous Solid 4.1 HMDB15003 CHEMBL1201358 4470556 <p>Dennis J. Kalota, Keith G. Tomazi, &#8220;Crystallization Method for Benzphetamine.&#8221; U.S. Patent US20080262268, issued October 23, 2008.</p> CHEM002293 DTXSID4022656 NS00007945 benzyl(methyl)[(2S)-1-phenylpropan-2-yl]amine 3.24 78.38710000000002 29.02921849827269 5 1 0 9.719455366577789 1 2 3.72 -4.01 2.33e-02 g/l Organic compounds Benzenoids Benzene and substituted derivatives Phenethylamines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 776t3gAAAAAQAAAAAwAAAAAAAAASAAAAEwAAAIABBgBgAAAAAQMGIDQAAAAB AQQGAGAAAAACAgZAKAAAAAMEBkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMB BkBoAAAAAwMBBkBoAAAAAwMBBwAgAAAAAwYAYAAAAAEDBgBgAAAAAgIGQCgA AAADBAZAaAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMDAQZAaAAA AAMDAQsAAQABAgACAwADBGgMBAVoDAUGaAwGB2gMBwhoDAEJAAkKAAkLAAsM AAwNaAwNDmgMDg9oDA8QaAwQEWgMCANoDBEMaAxCAgAAAAYEBQYHCAMGDQ4P EBEMFwQAAAAAAAAAFg== 2026-09-19T04:00:39Z