3637 epsilon-Amanitin epsilon-Amanitin is an exogenous solid with the chemical formula C39H53N9O14S. epsilon-Amanitin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 903.96 g/mol, epsilon-Amanitin is a heavy molecule. This compound is one of a group of at least eight Amatoxins found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis, and hence cell metabolism, grind to a halt and the cell dies. 21705-02-2 57473119 C39H53N9O14S 903.95502 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis, and hence cell metabolism, grind to a halt and the cell dies. (L1774) LD50: 0.3-0.6 mg/kg (Mouse) (T258) 0.1 mg/kg for an adult human. (L1774) No indication of carcinogenicity to humans (not listed by IARC). Amatoxins are a subgroup of at least eight toxic compounds found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. (L1774) Amatoxins cause liver damage. They may also affect the kidneys. The most severe effects are toxic hepatitis with centrolobular necrosis and hepatic steatosis, as well as acute tubulointerstitial nephropathy, which altogether induce a severe hepatorenal syndrome. (L1774) Diarrhea and cramps are the first symptoms. (L993) Treatment involves high dose penicillin as well as supportive care in cases of hepatic and renal injury. Cautious attention is given to maintaining hemodynamic stability, although if hepatorenal syndrome has developed the prognosis is guarded at best. (L1774) 2009-08-12T21:34:05Z 2026-04-06T12:33:18Z http://en.wikipedia.org/wiki/Epsilon-Amanitin Amanitin, epsilon- true [H][C@@](C)(O)[C@]([H])(C)[C@]1([H])N=C(O)[C@]2([H])C[C@@]([H])(O)CN2C(=O)[C@]([H])(CC(O)=O)N=C(O)[C@]2([H])CS(=O)C3=C(C[C@@]([H])(N=C1O)C(O)=NCC(O)=N[C@]([H])(C(O)=NCC(O)=N2)[C@@]([H])(C)CC)C1=C(N3)C=C(O)C=C1 C39H53N9O14S InChI=1S/C39H53N9O14S/c1-5-16(2)31-36(59)41-12-28(52)42-26-15-63(62)38-22(21-7-6-19(50)8-23(21)45-38)10-24(33(56)40-13-29(53)46-31)43-37(60)32(17(3)18(4)49)47-35(58)27-9-20(51)14-48(27)39(61)25(11-30(54)55)44-34(26)57/h6-8,16-18,20,24-27,31-32,45,49-51H,5,9-15H2,1-4H3,(H,40,56)(H,41,59)(H,42,52)(H,43,60)(H,44,57)(H,46,53)(H,47,58)(H,54,55)/t16-,17-,18-,20+,24-,25-,26-,27-,31-,32-,63?/m0/s1 OFILNAORONITPV-ZUROAWGWSA-N 903.96 903.343268597 Exogenous Solid 26234941 CHEM002566 NS00124015 379.29 221.5929000000001 88.63126241062582 6 21 12 2.6424904898324795 -1 5 0.42 -2.84 1.30e+00 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 0 CED0030568 OFILNAORONITPV-BZTWOJTESA-N 4420000000200000000080000020010001000000400000000000000011000200000000100200002a01000000004000240400000000000000020000080000c000000000000000000000020080000000020020000000080000801004001040000000000000010200000001000000104000000000020100000000002000000800100000000040000000400000200010000000000000000000000000000030400002010c0800c020400000040000080010000000000000000000010000000000000800800400000000003004080108404000002000048000000004406200000000000000000008000000000044000000000400000000008000400000220000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAA/AAAAQwAAAIABBiA0AAAAAgEEBgBgAAAA AQMIAGAAAAABAQYgNAAAAAIBBAYAYAAAAAEDBiA0AAAAAgEEBwAoAAAAAwMG ACgAAAADBAgAaAAAAAMBAQYgNAAAAAIBBAYAYAAAAAICBiA0AAAAAQEECABg AAAAAQEGAGAAAAACAgcAKAAAAAMDBgAoAAAAAwQIACgAAAADAgYgNAAAAAIB BAYAYAAAAAICBgAoAAAAAwQIAGgAAAADAQEIACgAAAADAgcAKAAAAAMDBgAo AAAAAwQIAGgAAAADAQEGIDQAAAACAQQGAGAAAAACAhAAIAAAAAQIACgAAAAD AgZAKAAAAAMEBkAoAAAAAwQGAGAAAAACAgYgNAAAAAEBBAcAKAAAAAMDBgAo AAAAAwQIAGgAAAADAQEGACgAAAADBAgAaAAAAAMBAQcAKAAAAAMDBgBgAAAA AgIGACgAAAADBAgAaAAAAAMBAQcAKAAAAAMDBiA0AAAAAgEEBgAoAAAAAwQI AGgAAAADAQEHACgAAAADAwYAYAAAAAICBgAoAAAAAwQIAGgAAAADAQEHACgA AAADAwYgNAAAAAEBBAYAYAAAAAEDBgBgAAAAAgIGAGAAAAABAwZAKAAAAAME BkAoAAAAAwQHQDgAAAADAQMGQGgAAAADAwEGQCgAAAADBAgAaAAAAAMBAQZA aAAAAAMDAQZAaAAAAAMDAQsAAQAAAgAAAwADBAADBQAFBgAGBygCBwggBwkA CQoACgsACwwACw0ADQ4ADg8gDxAoAg8RABESABITABMUIBMVKAIRFgAWFygC FxggFxkAGRoAGhsAGxwIAhsdAB0eaAweHwAfIAAgIQAhIigCIiMgICQAJCUg JCYoAiYnACcoACgpICgqKAIqKwArLAAsLSAsLigCLi8ALzAAMDEgMDIoAisz ADM0ADM1ADU2AB43aAw3OGgMODloDDg6aAw6O2gMOzwgOz1oDD0+aAwiBQA+ N2gMDgkAMhkAOR1oDEIFAAAABQoJDg0LBTk4Nx4dBjo7PT43OBIFIiEgHx4d GxoZFxYRDw4JBwYSGhsdHh8gJCYnKCorLC4vMDIZFwQAAAAAAAAAFg== 2026-09-19T04:00:49Z