3638 Amanullin Amanullin is an exogenous compound that exists as a solid at room temperature. It has the chemical formula C39H54N10O12S. Amanullin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 886.97 g/mol, Amanullin is a heavy molecule. The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, which is a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). When mRNA is absent, cell metabolism and essential protein synthesis grind to a halt, resulting in cell death. 21803-57-6 114856 C39H54N10O12S 887 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis, and hence cell metabolism, grind to a halt and the cell dies. (L1774) LD50: >20 mg/kg (Mouse) (T258) 0.1 mg/kg for an adult human. (L1774) No indication of carcinogenicity to humans (not listed by IARC). Amatoxins are a subgroup of at least eight toxic compounds found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. (L1774) Amatoxins cause liver damage. They may also affect the kidneys. The most severe effects are toxic hepatitis with centrolobular necrosis and hepatic steatosis, as well as acute tubulointerstitial nephropathy, which altogether induce a severe hepatorenal syndrome. (L1774) Diarrhea and cramps are the first symptoms. (L993) Treatment involves high dose penicillin as well as supportive care in cases of hepatic and renal injury. Cautious attention is given to maintaining hemodynamic stability, although if hepatorenal syndrome has developed the prognosis is guarded at best. (L1774) 2009-08-12T21:34:05Z 2026-08-31T23:09:15Z http://en.wikipedia.org/wiki/Amanullin Amanullin true CCC(C)C1NC(=O)CNC(=O)C2CC3=C(NC4=CC(O)=CC=C34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)N1CC(O)CC1C(=O)NC(C(C)CC)C(=O)N2 C39H54N10O12S InChI=1S/C39H54N10O12S/c1-5-17(3)31-36(58)42-13-29(53)43-26-16-62(61)38-22(21-8-7-19(50)9-23(21)46-38)11-24(33(55)41-14-30(54)47-31)44-37(59)32(18(4)6-2)48-35(57)27-10-20(51)15-49(27)39(60)25(12-28(40)52)45-34(26)56/h7-9,17-18,20,24-27,31-32,46,50-51H,5-6,10-16H2,1-4H3,(H2,40,52)(H,41,55)(H,42,58)(H,43,53)(H,44,59)(H,45,56)(H,47,54)(H,48,57) QQLVIKWYAVVKKF-UHFFFAOYSA-N 886.971 886.364337932 Exogenous Solid -2.2 102814 CHEM002567 NS00124752 2-[13,34-di(butan-2-yl)-8,22-dihydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27lambda4-thia-3,6,12,15,25,29,32,35,38-nonazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19(24),20,22-tetraen-4-yl]acetamide 340.41999999999996 218.11550000000014 88.07029780740064 6 12 11 9.385735943676053 -5.529577316852756 0 5 -0.77 -2.31 4.38e+00 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 1 CED0030195 QQLVIKWYAVVKKF-UHFFFAOYSA-N 440010040020000000008000000411002008000000000000200000000100000000000010020400280000000000400004000000000000008000000000000081000000000000000000000300000000000000200000000800008010000010400000000000000100000000830008101000400000000201000000000060000208001002200008c000000040000020000000000000100000000000000000000040000200080000c020000000040000080000000000000080000000000000002008000801800000010000002000080108404000000000440000000004004200000000000000000200000000002044000020000500000000008000200000000000000000 7006c0508d33c620c9fc536783f8b288995034ba9517a074cd3c60548b38eacc6c66015813a0204c8740412890c0200295600ba5c08e72350bcf7d7dc0e24106c711948d1ad01600c29013d01a722a604844c59151611fb753544d6654221bb7cd78656f184cb230609a9184ddf40045708692f28191e5a6b15b2e7983d51917584418195ef8a60a0c1f03d0ee2c42a8393cda1245c2be8b72320ca462d8478451d710d319b6d2b30b866d68877c3d154ac12243a9418ac858b14ab0cce24a12a21110a5bddb53331dc026a65755c2990c316014032478628d70f60e2e01030491386d3618c94b3d1b6ca453db56a08e1e50263492c6042f53199b82da0a0c46 776t3gAAAAAQAAAAAwAAAAAAAAA+AAAAQgAAAIABBgBgAAAAAQMGAGAAAAAC AgYAYAAAAAMBBgBgAAAAAQMGAGAAAAADAQcAaAAAAAMCAQYAKAAAAAMECAAo AAAAAwIGAGAAAAACAgcAaAAAAAMCAQYAKAAAAAMECAAoAAAAAwIGAGAAAAAD AQYAYAAAAAICBkAoAAAAAwQGQCgAAAADBAdAOAAAAAMBAwZAKAAAAAMEBkBo AAAAAwMBBkAoAAAAAwQIAGgAAAADAQEGQGgAAAADAwEGQGgAAAADAwEGQCgA AAADBBAAIAAAAAQIACgAAAADAgYAYAAAAAICBgBgAAAAAwEHAGgAAAADAgEG ACgAAAADBAgAKAAAAAMCBgBgAAAAAgIHAGgAAAADAgEGACgAAAADBAgAKAAA AAMCBgAoAAAAAwQIACgAAAADAgcAaAAAAAMCAQYAYAAAAAMBBgBgAAAAAgIG ACgAAAADBAcAaAAAAAMBAggAKAAAAAMCBgAoAAAAAwQIACgAAAADAgcAKAAA AAMDBgBgAAAAAgIGAGAAAAADAQgAYAAAAAEBBgBgAAAAAgIGAGAAAAADAQYA KAAAAAMECAAoAAAAAwIHAGgAAAADAgEGAGAAAAADAQYAYAAAAAMBBgBgAAAA AQMGAGAAAAACAgYAYAAAAAEDBgAoAAAAAwQIACgAAAADAgcAaAAAAAMCAQsA AQABAgACAwACBAAEBQAFBiAGBygCBggACAkACQogCgsoAgoMAAwNAA0OAA4P aAwPEGgMEBFoDBESaAwSE2gMExQgExVoDBUWaAwWF2gMDxgAGBkIAhgaABob ABscABwdIB0eKAIdHwAfIAAgISAhIigCGyMAIyQoAiMlICUmACYnACcoACgp ICgqKAImKwArLCgCKy0gLS4ALi8ALzAALzEAMTIAMjMAMzQoAjM1IDU2ADY3 ADc4ADc5ADk6ADY7ADs8KAI7PSAhBAAyLQA9DAAXDmgMFxFoDEIFAAAABRAP DhcRBS4tMjEvBhITFRYXERIEISAfHRwbGhgPDg0MCgkIBgUSDQ4PGBobIyUm Ky0yMzU2Oz0MFwQAAAAAAAAAFg== 2026-09-19T04:00:49Z