3639 Amanullinic acid Amanullinic acid is an exogenous organic compound that exists as a solid at room temperature. It is characterized by the chemical formula C39H53N9O13S. With an average molecular weight of 887.96 g/mol, Amanullinic acid is a heavy molecule. Amanullinic acid belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. The compound is one of a group of at least eight Amatoxins found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. Regarding its biological activity, the major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, which is a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). The resulting lack of mRNA prevents essential protein synthesis and cell metabolism, causing the cell to die. 54532-45-5 171349 C39H53N9O13S 888 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis, and hence cell metabolism, grind to a halt and the cell dies. (L1774) LD50: >20 mg/kg (Mouse) (T258) 0.1 mg/kg for an adult human. (L1774) No indication of carcinogenicity to humans (not listed by IARC). Amatoxins are a subgroup of at least eight toxic compounds found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. (L1774) Amatoxins cause liver damage. They may also affect the kidneys. The most severe effects are toxic hepatitis with centrolobular necrosis and hepatic steatosis, as well as acute tubulointerstitial nephropathy, which altogether induce a severe hepatorenal syndrome. (L1774) Diarrhea and cramps are the first symptoms. (L993) Treatment involves high dose penicillin as well as supportive care in cases of hepatic and renal injury. Cautious attention is given to maintaining hemodynamic stability, although if hepatorenal syndrome has developed the prognosis is guarded at best. (L1774) 2009-08-12T21:34:06Z 2026-08-31T23:08:58Z http://en.wikipedia.org/wiki/Amanullinic_acid Amanullinic acid true CCC(C)C1NC(=O)CNC(=O)C2CC3=C(NC4=CC(O)=CC=C34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(O)=O)C(=O)N1CC(O)CC1C(=O)NC(C(C)CC)C(=O)N2 C39H53N9O13S InChI=1S/C39H53N9O13S/c1-5-17(3)31-36(58)41-13-28(51)42-26-16-62(61)38-22(21-8-7-19(49)9-23(21)45-38)11-24(33(55)40-14-29(52)46-31)43-37(59)32(18(4)6-2)47-35(57)27-10-20(50)15-48(27)39(60)25(12-30(53)54)44-34(26)56/h7-9,17-18,20,24-27,31-32,45,49-50H,5-6,10-16H2,1-4H3,(H,40,55)(H,41,58)(H,42,51)(H,43,59)(H,44,56)(H,46,52)(H,47,57)(H,53,54) HFENEIQMWRYNGK-UHFFFAOYSA-N 887.956 887.348353517 Exogenous Solid -1.6 149798 CHEM002568 NS00121894 2-[13,34-di(butan-2-yl)-8,22-dihydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27lambda4-thia-3,6,12,15,25,29,32,35,38-nonazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19(24),20,22-tetraen-4-yl]acetic acid 334.62999999999994 216.29330000000016 87.72003616402505 6 13 11 3.646986074183188 -5.529577316852756 -1 5 -0.55 -2.38 3.74e+00 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 3796327 CED0034443 HFENEIQMWRYNGK-UHFFFAOYSA-N 440010040020000000008000000411002000000000000000200000000100000000000010020400280000000000400004040000000000008000000000000081000000000000000000000300000000000000200000000800008010000010400000000000000100000000810008101000400000000201000000000060000208001002200008c000000040000020000000000000000000000000000000000040000200080000c020000000040000080000000000000080000000000000002008000801800000010000002000080108404000000000440000000004406200000000000000000000000000002044000000000500000000008000200000000000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAA+AAAAQgAAAIABBgBgAAAAAQMGAGAAAAAC AgYAYAAAAAMBBgBgAAAAAQMGAGAAAAADAQcAaAAAAAMCAQYAKAAAAAMECAAo AAAAAwIGAGAAAAACAgcAaAAAAAMCAQYAKAAAAAMECAAoAAAAAwIGAGAAAAAD AQYAYAAAAAICBkAoAAAAAwQGQCgAAAADBAdAOAAAAAMBAwZAKAAAAAMEBkBo AAAAAwMBBkAoAAAAAwQIAGgAAAADAQEGQGgAAAADAwEGQGgAAAADAwEGQCgA AAADBBAAIAAAAAQIACgAAAADAgYAYAAAAAICBgBgAAAAAwEHAGgAAAADAgEG ACgAAAADBAgAKAAAAAMCBgBgAAAAAgIHAGgAAAADAgEGACgAAAADBAgAKAAA AAMCBgAoAAAAAwQIACgAAAADAgcAaAAAAAMCAQYAYAAAAAMBBgBgAAAAAgIG ACgAAAADBAgAaAAAAAMBAQgAKAAAAAMCBgAoAAAAAwQIACgAAAADAgcAKAAA AAMDBgBgAAAAAgIGAGAAAAADAQgAYAAAAAEBBgBgAAAAAgIGAGAAAAADAQYA KAAAAAMECAAoAAAAAwIHAGgAAAADAgEGAGAAAAADAQYAYAAAAAMBBgBgAAAA AQMGAGAAAAACAgYAYAAAAAEDBgAoAAAAAwQIACgAAAADAgcAaAAAAAMCAQsA AQABAgACAwACBAAEBQAFBiAGBygCBggACAkACQogCgsoAgoMAAwNAA0OAA4P aAwPEGgMEBFoDBESaAwSE2gMExQgExVoDBUWaAwWF2gMDxgAGBkIAhgaABob ABscABwdIB0eKAIdHwAfIAAgISAhIigCGyMAIyQoAiMlICUmACYnACcoACgp ICgqKAImKwArLCgCKy0gLS4ALi8ALzAALzEAMTIAMjMAMzQoAjM1IDU2ADY3 ADc4ADc5ADk6ADY7ADs8KAI7PSAhBAAyLQA9DAAXDmgMFxFoDEIFAAAABRAP DhcRBS4tMjEvBhITFRYXERIEISAfHRwbGhgPDg0MCgkIBgUSDQ4PGBobIyUm Ky0yMzU2Oz0MFwQAAAAAAAAAFg== 2026-09-19T04:00:49Z