3641 Amanin Amanin is an exogenous compound that exists as a solid at room temperature. It has the chemical formula C39H53N9O14S. With an average molecular weight of 903.96 g/mol, Amanin is a heavy molecule. Amanin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. The compound is one of a group of at least eight Amatoxins found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. Regarding its biological activity, the major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, which is a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). The inhibition of this enzyme prevents the production of mRNA, which causes essential protein synthesis and cell metabolism to grind to a halt, resulting in cell death. 21150-21-0 30508 C39H53N9O14S White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis, and hence cell metabolism, grind to a halt and the cell dies. (L1774) LD50: 0.5 mg/kg (Mouse) (T258) 0.1 mg/kg for an adult human. (L1774) No indication of carcinogenicity to humans (not listed by IARC). Amatoxins are a subgroup of at least eight toxic compounds found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. (L1774) Amatoxins cause liver damage. They may also affect the kidneys. The most severe effects are toxic hepatitis with centrolobular necrosis and hepatic steatosis, as well as acute tubulointerstitial nephropathy, which altogether induce a severe hepatorenal syndrome. (L1774) Diarrhea and cramps are the first symptoms. (L993) Treatment involves high dose penicillin as well as supportive care in cases of hepatic and renal injury. Cautious attention is given to maintaining hemodynamic stability, although if hepatorenal syndrome has developed the prognosis is guarded at best. (L1774) 2009-08-12T21:34:07Z 2026-04-06T12:33:17Z http://en.wikipedia.org/wiki/Amanin Amanin true CCC(C)C1NC(=O)CNC(=O)C2CC3=C(NC4=CC(O)=CC=C34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(O)=O)C(=O)N1CC(O)CC1C(=O)NC(C(C)C(C)O)C(=O)N2 C39H53N9O14S InChI=1S/C39H53N9O14S/c1-5-16(2)31-36(59)41-12-28(52)42-26-15-63(62)38-22(21-7-6-19(50)8-23(21)45-38)10-24(33(56)40-13-29(53)46-31)43-37(60)32(17(3)18(4)49)47-35(58)27-9-20(51)14-48(27)39(61)25(11-30(54)55)44-34(26)57/h6-8,16-18,20,24-27,31-32,45,49-51H,5,9-15H2,1-4H3,(H,40,56)(H,41,59)(H,42,52)(H,43,60)(H,44,57)(H,46,53)(H,47,58)(H,54,55) OFILNAORONITPV-UHFFFAOYSA-N 903.955 903.343268139 Exogenous Solid 28316 CHEM002570 NS00124014 354.85999999999996 217.94100000000014 88.48894329315296 6 14 12 3.6469860606765017 -5.529577316852756 -1 5 -0.95 -2.15 6.44e+00 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 12 CED0029100 OFILNAORONITPV-UHFFFAOYSA-N 440010040020000000008000000411002000000000000000200000001100000000000010020400280000000000400004040000000000008000000000000081000000000000000000000300000000000000200000000800008010000010400000000000000100000000810008101000400000000201000000000060000208001002200008c000000040000060000000000000000000000000000000000040000200080000c020000000040000080000000000000080000000000000002008000801800000010000003000080108404000000200440000000004406200000000000000000008000000002044000000000500000000008000200000000000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAA/AAAAQwAAAIABBgBgAAAAAQMGAGAAAAAC AgYAYAAAAAMBBgBgAAAAAQMGAGAAAAADAQcAaAAAAAMCAQYAKAAAAAMECAAo AAAAAwIGAGAAAAACAgcAaAAAAAMCAQYAKAAAAAMECAAoAAAAAwIGAGAAAAAD AQYAYAAAAAICBkAoAAAAAwQGQCgAAAADBAdAOAAAAAMBAwZAKAAAAAMEBkBo AAAAAwMBBkAoAAAAAwQIAGgAAAADAQEGQGgAAAADAwEGQGgAAAADAwEGQCgA AAADBBAAIAAAAAQIACgAAAADAgYAYAAAAAICBgBgAAAAAwEHAGgAAAADAgEG ACgAAAADBAgAKAAAAAMCBgBgAAAAAgIHAGgAAAADAgEGACgAAAADBAgAKAAA AAMCBgAoAAAAAwQIACgAAAADAgcAaAAAAAMCAQYAYAAAAAMBBgBgAAAAAgIG ACgAAAADBAgAaAAAAAMBAQgAKAAAAAMCBgAoAAAAAwQIACgAAAADAgcAKAAA AAMDBgBgAAAAAgIGAGAAAAADAQgAYAAAAAEBBgBgAAAAAgIGAGAAAAADAQYA KAAAAAMECAAoAAAAAwIHAGgAAAADAgEGAGAAAAADAQYAYAAAAAMBBgBgAAAA AQMGAGAAAAADAQYAYAAAAAEDCABgAAAAAQEGACgAAAADBAgAKAAAAAMCBwBo AAAAAwIBCwABAAECAAIDAAIEAAQFAAUGIAYHKAIGCAAICQAJCiAKCygCCgwA DA0ADQ4ADg9oDA8QaAwQEWgMERJoDBITaAwTFCATFWgMFRZoDBYXaAwPGAAY GQgCGBoAGhsAGxwAHB0gHR4oAh0fAB8gACAhICEiKAIbIwAjJCgCIyUgJSYA JicAJygAKCkgKCooAiYrACssKAIrLSAtLgAuLwAvMAAvMQAxMgAyMwAzNCgC MzUgNTYANjcANzgANzkAOToAOTsANjwAPD0oAjw+ICEEADItAD4MABcOaAwX EWgMQgUAAAAFEA8OFxEFLi0yMS8GEhMVFhcREgQhIB8dHBsaGA8ODQwKCQgG BRINDg8YGhsjJSYrLTIzNTY8PgwXBAAAAAAAAAAW 2026-09-19T04:00:49Z