3642 Proamanullin Proamanullin is an exogenous compound that exists as a solid at room temperature. It has the chemical formula C39H54N10O11S. Proamanullin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 870.97 g/mol, Proamanullin is a heavy molecule. The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis, and hence cell metabolism, grind to a halt and the cell dies. 54532-46-6 171350 C39H54N10O11S 871 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis, and hence cell metabolism, grind to a halt and the cell dies. (L1774) LD50: >20 mg/kg (Mouse) (A690) 0.1 mg/kg for an adult human. (L1774) No indication of carcinogenicity to humans (not listed by IARC). Amatoxins are a subgroup of at least eight toxic compounds found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. (L1774) Amatoxins cause liver damage. They may also affect the kidneys. The most severe effects are toxic hepatitis with centrolobular necrosis and hepatic steatosis, as well as acute tubulointerstitial nephropathy, which altogether induce a severe hepatorenal syndrome. (L1774) Diarrhea and cramps are the first symptoms. (L993) Treatment involves high dose penicillin as well as supportive care in cases of hepatic and renal injury. Cautious attention is given to maintaining hemodynamic stability, although if hepatorenal syndrome has developed the prognosis is guarded at best. (L1774) 2009-08-12T21:34:08Z 2026-08-31T23:09:14Z Proamanullin true CCC(C)C1NC(=O)CNC(=O)C2CC3=C(NC4=CC(O)=CC=C34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)N2 C39H54N10O11S InChI=1S/C39H54N10O11S/c1-5-18(3)31-36(57)42-15-29(52)43-26-17-61(60)38-22(21-10-9-20(50)12-23(21)46-38)13-24(33(54)41-16-30(53)47-31)44-37(58)32(19(4)6-2)48-35(56)27-8-7-11-49(27)39(59)25(14-28(40)51)45-34(26)55/h9-10,12,18-19,24-27,31-32,46,50H,5-8,11,13-17H2,1-4H3,(H2,40,51)(H,41,54)(H,42,57)(H,43,52)(H,44,58)(H,45,55)(H,47,53)(H,48,56) CTYHFRWAIRSHQT-UHFFFAOYSA-N 870.971 870.36942331 Exogenous Solid -1.2 149799 CHEM002571 NS00120832 2-[13,34-di(butan-2-yl)-22-hydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27lambda4-thia-3,6,12,15,25,29,32,35,38-nonazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19(24),20,22-tetraen-4-yl]acetamide 320.18999999999994 216.79760000000013 86.75416948790094 6 11 10 9.391168159755937 -5.529577316852756 0 5 -0.19 -2.74 1.57e+00 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues 0 CED0034458 CTYHFRWAIRSHQT-UHFFFAOYSA-N 44001004002000000000800000041100200800000000000020000000010000000000001002040028000008000040000400000000000000820000000000008100000000000000000000000000000000200020000000080000801000000040000000000000010000000083000810100040000000020100000000006000020800100a200008c000000040000020000000000000100000000000000000000000000200000000c004000000040000080000000000000080000000008000002008001801800000010000002000000100404000000000440000000004004200000000000000000200000000002044000020000500000000000000200000000000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAA9AAAAQQAAAIABBgBgAAAAAQMGAGAAAAAC AgYAYAAAAAMBBgBgAAAAAQMGAGAAAAADAQcAaAAAAAMCAQYAKAAAAAMECAAo AAAAAwIGAGAAAAACAgcAaAAAAAMCAQYAKAAAAAMECAAoAAAAAwIGAGAAAAAD AQYAYAAAAAICBkAoAAAAAwQGQCgAAAADBAdAOAAAAAMBAwZAKAAAAAMEBkBo AAAAAwMBBkAoAAAAAwQIAGgAAAADAQEGQGgAAAADAwEGQGgAAAADAwEGQCgA AAADBBAAIAAAAAQIACgAAAADAgYAYAAAAAICBgBgAAAAAwEHAGgAAAADAgEG ACgAAAADBAgAKAAAAAMCBgBgAAAAAgIHAGgAAAADAgEGACgAAAADBAgAKAAA AAMCBgAoAAAAAwQIACgAAAADAgcAaAAAAAMCAQYAYAAAAAMBBgBgAAAAAgIG ACgAAAADBAcAaAAAAAMBAggAKAAAAAMCBgAoAAAAAwQIACgAAAADAgcAKAAA AAMDBgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBgBgAAAAAwEGACgAAAADBAgA KAAAAAMCBwBoAAAAAwIBBgBgAAAAAwEGAGAAAAADAQYAYAAAAAEDBgBgAAAA AgIGAGAAAAABAwYAKAAAAAMECAAoAAAAAwIHAGgAAAADAgELAAEAAQIAAgMA AgQABAUABQYgBgcoAgYIAAgJAAkKIAoLKAIKDAAMDQANDgAOD2gMDxBoDBAR aAwREmgMEhNoDBMUIBMVaAwVFmgMFhdoDA8YABgZCAIYGgAaGwAbHAAcHSAd HigCHR8AHyAAICEgISIoAhsjACMkKAIjJSAlJgAmJwAnKAAoKSAoKigCJisA KywoAistIC0uAC4vAC8wADAxADEyADIzKAIyNCA0NQA1NgA2NwA2OAA4OQA1 OgA6OygCOjwgIQQAMS0APAwAFw5oDBcRaAxCBQAAAAUQDw4XEQUuLTEwLwYS ExUWFxESBCEgHx0cGxoYDw4NDAoJCAYFEg0ODxgaGyMlJistMTI0NTo8DBcE AAAAAAAAABY= 2026-09-19T04:00:49Z