3731 Cytochalasin D Cytochalasin D belongs to the cytochalasans, a class of alkaloids and derivatives within the organic compounds. With an average molecular weight of 507.62 g/mol, Cytochalasin D is a heavy molecule. This exogenous compound has the formula C30H37NO6 and exists as a solid at room temperature. It is categorized as a mycotoxin, an antineoplastic agent, a DNA synthesis inhibitor, and an actin polymerisation inhibitor. It has been found in antibiotics within healthcare, pharmaceuticals, and veterinary products, with recorded exposure routes including oral and inhalation. The compound targets several proteins, including actin, cytoplasmic 1 (ACTB), actin, cytoplasmic 2 (ACTG1), actin, aortic smooth muscle (ACTA2), and actin, alpha skeletal muscle (ACTA1). Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monomers from the bound end. Once bound, cytochalasin essentially caps the end of the new actin filament, with one cytochalasin binding to one actin filament. By blocking the polymerization and elongation of actin, cytochalasins can change cellular morphology, inhibit cellular processes such as cell division, and cause cells to undergo apoptosis. 22144-77-0 6433799 C30H37NO6 White powder. 255°C Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monomers from the bound end. Once bound, cytochalasin essentially caps the end of the new actin filament. One cytochalasin will bind to one actin filament. By blocking the polymerization and elongation of actin, cytochalasins can change cellular morphology, inhibit cellular processes such as cell division, and cause cells to undergo apoptosis. Cytochalasin D also inhibits protein synthesis. (A2910, A2911, L1913) LD50: 18.5 mg/kg (Subcutaneous, Mouse) (A2912) No indication of carcinogenicity to humans (not listed by IARC). Cytochalasin D is has been isolated from the fungi Metarrhizium anisopliae and Zygosporium masonii. (A2912) Major biological effects of cytochalasins include inhibition of the division of cytoplasm, reversible inhibition of cell movement, induction of nuclear extrusion, inhibition of such processes as phagocytosis, platelet aggregation and clot retraction, glucose transport, thyroid secretion, and release of growth hormone. Some cytochalasins have been shown to have developmental effects. (L1916) Consider activated charcoal after gastrointestinal absportion. Nitroprusside is recommended to reverse peripheral ischemia secondary to vasoconstriction and for the treatment of hypertension. Anticoagulant therapy with intravenous heparin is also recommended. (A704) 2010-04-16T17:41:35Z 2026-03-31T20:45:27Z http://en.wikipedia.org/wiki/Cytochalasin_D true CC1C2C(CC3=CC=CC=C3)NC(=O)C22C(\C=C\CC(C)C(=O)C(C)(O)\C=C\C2OC(C)=O)C(O)C1=C C30H37NO6 InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+ SDZRWUKZFQQKKV-BBXOWAOSSA-N 507.6179 507.262087921 Exogenous Solid CHEMBL1975837 4938858 CHEM002647 DTXSID8037099 NS00011653 112.93 141.5228 54.535388722550806 4 5 3 12.848232228884065 -0.3728268033187402 0 4 2.89 -4.94 5.80e-03 g/l Organic compounds Alkaloids and derivatives Cytochalasans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 776t3gAAAAAQAAAAAwAAAAAAAAAlAAAAKAAAAIABBgBgAAAAAQMGAGAAAAAD AQYAYAAAAAMBBgBgAAAAAwEGAGAAAAACAgZAKAAAAAMEBkBoAAAAAwMBBkBo AAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMBBwBoAAAAAwIBBgAo AAAAAwQIACgAAAADAgYAIAAAAAQGAGAAAAADAQYAaAAAAAMDAQYAaAAAAAMD AQYAYAAAAAICBgBgAAAAAwEGAGAAAAABAwYAKAAAAAMECAAoAAAAAwIGACAA AAAEBgBgAAAAAQMIAGAAAAABAQYAaAAAAAMDAQYAaAAAAAMDAQYAYAAAAAMB CAAoAAAAAwIGACgAAAADBAYAYAAAAAEDCAAoAAAAAwIGAGAAAAADAQgAYAAA AAEBBgAoAAAAAwQGAGgAAAADAgILAAEAAQIAAgMAAwQABAUABQZoDAYHaAwH CGgMCAloDAkKaAwDCwALDCAMDSgCDA4ADg8ADxAEAxARCgIDAg8SERIEAxIT ABMUABMVABUWCAIVFwAXGAAXGQAXGgQDGhsKAgMCFxwbHAQDHB0AHR4gHh8A HiAoAg8hACEiACEjACMkCAIjAQAOAgAcDgAKBWgMQgQAAAAGASMhDw4CBgYH CAkKBQULAwIODAsQDw4cGxoXFRMSERcEAAAAAAAAABY= 2026-09-19T04:00:52Z