3778 Bovinocidin Bovinocidin is isolated from Aspergillus sp. and moulds contaminating food Bovinocidin belongs to the family of Beta Amino Acids and Derivatives. These are amino acids having a (-NH2) group attached to the beta carbon atom. 504-88-1 1678 C3H5NO4 White powder. 64 - 65°C Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) 3-Nitropropionic acid is a suicide inhibitor of succinate dehydrogenase, an enzyme required for the activity of the tricarboxylic acid (TCA) cycle as well as mitochondrial respiratory complex II of the electron transport chain. It forms a covalent adduct with the side chain of Arg297, inactivating the succinate dehydrogenase. This affects neurons by leading to NMDA-receptor activation, excessive calcium influx, and formation of reactive oxygen species, eventually causing neuronal cell death. (A2967, A2968) No indication of carcinogenicity to humans (not listed by IARC). 3-Nitropropionic acid is a neurotoxin produced by certain plants and fungi, such as those of the genus Astragalus, Coronilla, Lotus, Hippocrepis, Scorpiurus, and Securigera. It produces symptoms similar to that of Huntington disease and this thus often used to produced animal models for the study of the disease. (A2967, A2968, A2970) 3-Nitropropionic acid causes neurodegeneration, particularity of the striatum, though also in the hippocampus and thalamus. (A2967, A2971) 3-Nitropropionic acid causes symptoms similar to that of Huntington disease: motor and cognitive dysfunction that includes convulsions, dystonia, and hypokinesia. (A2967, A2969, A2971) 2010-05-03T15:06:51Z 2026-04-04T02:23:06Z C05669 16348 3NP true OC(=O)CCN(=O)=O C3H5NO4 InChI=1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6) WBLZUCOIBUDNBV-UHFFFAOYSA-N 119.0761 119.021857653 Exogenous Solid HMDB34259 CHEMBL451226 1615 CHEM002693 DTXSID1020982 3-nitropropanoic acid