3785 Rubratoxin A Rubratoxin A is an exogenous compound that exists as a solid at room temperature. It has the chemical formula C26H32O11. Rubratoxin A belongs to the tetracarboxylic acids and derivatives, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 520.53 g/mol, Rubratoxin A is a heavy molecule. The compound acts as a potent inhibitor of protein phosphatase 2A, specifically targeting the serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA), the serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB), and the serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A). This inhibition exerts antitumor and antimetastatic effects. These antimetastatic effects may be attributed to the phosphorylation of CREB and subsequent activation of natural killer cells via the stimulation of interleukin-2 release from T cells, as well as the phosphorylation of focal adhesion kinase and paxillin, which interferes with cell adhesion. Additionally, Rubratoxin A inhibits Na+/K+-transporting ATPases in the brain. The recorded protein targets for this action include the sodium/potassium-transporting ATPase subunit gamma (FXYD2), sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2), sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3), and four other proteins. 22467-31-8 31181 C26H32O11 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Rubratoxin A is a potent inhibitor of protein phosphatase 2A, exerting antitumor and antimetastatic effects. Inhibition may cause the phosphorylation of CREB and subsequent activation of natural killer cells via the stimulation of interleukin-2 release from T cells, contributing to antimetastatic effects. Focal adhesion kinase phosphorylation and paxillin phosphorylation that interfere with cell adhesion could be another antimetastatic effect. Rubratoxin A has also been shown to inhibit Na+/K+-transporting ATPases. (A2987, A2988) No indication of carcinogenicity to humans (not listed by IARC). Rubratoxin A is a mycotoxin produced by fungi such as Penicillum rubrum and Penicillum purpurogenum, which are common soil fungi that sometimes contaminate animal feeds. (A2985, A2988) Rubratoxins are hepatotoxic, nephrotoxic, and splenotoxic, causing congestive, hemorrhagic and degenerative lesions. (A2985, A2986) 2010-05-05T14:57:46Z 2026-04-06T13:51:16Z true CCCCCCC(O)C1C(O)C2=C(CC(CC3=C1C(=O)OC3O)C(O)C1CC=CC(=O)O1)C(=O)OC2=O C26H32O11 InChI=1S/C26H32O11/c1-2-3-4-5-7-15(27)20-18-13(23(31)36-25(18)33)10-12(21(29)16-8-6-9-17(28)35-16)11-14-19(22(20)30)26(34)37-24(14)32/h6,9,12,15-16,20-23,27,29-31H,2-5,7-8,10-11H2,1H3 XOEFANNJIKAWGX-UHFFFAOYSA-N 520.5257 520.194461866 Exogenous Solid 28923 CHEM002700 NS00126675 176.89 126.96669999999995 52.800797820607855 8 8 4 5.818870700637414 -2.8988760446550055 0 4 1.03 -3.01 5.10e-01 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Tetracarboxylic acids and derivatives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 776t3gAAAAAQAAAAAwAAAAAAAAAlAAAAKAAAAIABBgBgAAAAAQMGAGAAAAAC AgYAYAAAAAICBgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBgBgAAAAAwEIAGAA AAABAQYAYAAAAAMBBgBgAAAAAwEIAGAAAAABAQYAKAAAAAMEBgAoAAAAAwQG AGAAAAACAgYAYAAAAAMBBgBgAAAAAgIGACgAAAADBAYAKAAAAAMEBgAoAAAA AwQIACgAAAADAggAKAAAAAMCBgBgAAAAAwEIAGAAAAABAQYAYAAAAAMBCABg AAAAAQEGAGAAAAADAQYAYAAAAAICBgBoAAAAAwMBBgBoAAAAAwMBBgAoAAAA AwQIACgAAAADAggAKAAAAAMCBgAoAAAAAwQIACgAAAADAggAKAAAAAMCBgAo AAAAAwQIACgAAAADAgsAAQABAgACAwADBAAEBQAFBgAGBwAGCAAICQAJCgAJ CwALDCgCDA0ADQ4ADg8ADxAAEBEoAhESIBITKAISFCAUFQAVFgAOFwAXGAAX GQAZGgAaGwAbHCgCHB0gHR4oAh0fIAwgICAhKAIgIiAiIyAjJCgCEQgAHxkA IwsgFRAAQgQAAAAJCAkLDA0ODxARBRIREBUUBhobHB0fGQUgDAsjIhcEAAAA AAAAABY= 2026-09-19T04:00:53Z