3804 Aurovertin B Aurovertin B is an exogenous solid with the formula C25H32O8 and an average molecular weight of 460.52 g/mol. Aurovertin B belongs to the carbohydrates and carbohydrate conjugates, a subclass of organooxygen compounds within the organic compounds. This compound acts as a mixed, noncompetitive inhibitor of both ATP synthesis and ATP hydrolysis. It targets the proton-pumping F1F0-ATP synthase, which is responsible for the terminal step of oxidative phosphorylation. The recorded protein targets include the mitochondrial ATP synthase F(1) complex subunits alpha (ATP5F1A), beta (ATP5F1B), and gamma (ATP5F1C). Specifically, aurovertins are believed to bind with varying affinity to two of the three beta subunits on sites in a cleft between the C-terminal and nucleotide-binding domains to inhibit the enzyme. 55350-03-3 6441012 C25H32O8 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Aurovertins are a mixed, noncompetitive inhibitors of both ATP hydrolysis and synthesis. They do this by inhibiting the proton-pumping F1F0-ATP synthase by binding to beta-subunits in its F1 catalytic sector. F1F0-ATP synthase is responsible for the terminal step of oxidative phosphorylation. Each ATP synthase complex has three beta subunits, and aurovertins are believed to bind with varying affinity to two subunits on sites in a cleft between the nucleotide-binding and C-terminal domains, thus preventing closure of the catalytic interfaces necessary for the cyclic interconversion of catalytic sites. (A3032, A3033, A3034) No indication of carcinogenicity to humans (not listed by IARC). Aurovertin B is a mycotoxin and antibiotic produced by the fungus Calcarisporium arbuscula. (A3002) 2010-05-12T17:30:02Z 2026-04-05T13:12:47Z DB07394 true [H]/C(=C(/[H])\C(\[H])=C(/[H])C1=C(C)C(OC)=CC(=O)O1)/C(/[H])=C(\[H])C1OC2(C)C(CC)OC(C)(C2OC(C)=O)C1O C25H32O8 InChI=1S/C25H32O8/c1-7-20-24(4)23(30-16(3)26)25(5,33-20)22(28)18(32-24)13-11-9-8-10-12-17-15(2)19(29-6)14-21(27)31-17/h8-14,18,20,22-23,28H,7H2,1-6H3/b9-8+,12-10+,13-11+ QXCOFYWOWZJFEA-YIDQAKLOSA-N 460.523 460.20971799 Exogenous Solid CHEM002718 NS00071822 100.52000000000002 125.50259999999999 50.466648172042156 8 6 1 12.9124340730191 -3.7119013364614455 0 3 4.02 -4.62 1.10e-02 g/l Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates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 776t3gAAAAAQAAAAAwAAAAAAAAAhAAAAIwAAAIABBgA4AAAAAwEEBgA4AAAA AwEEBgA4AAAAAwEEBgA4AAAAAwEEBkAoAAAAAwQGQCgAAAADBAYAYAAAAAED BkAoAAAAAwQIACgAAAADAgYAYAAAAAEDBkBoAAAAAwMBBkAoAAAAAwQIACgA AAADAghAKAAAAAMCBgA4AAAAAwEEBgA4AAAAAwEEBgBgAAAAAwEIACAAAAAC BgAgAAAABAYAYAAAAAEDBgBgAAAAAwEGAGAAAAACAgYAYAAAAAEDCAAgAAAA AgYAIAAAAAQGAGAAAAABAwYAYAAAAAMBCAAoAAAAAwIGACgAAAADBAYAYAAA AAEDCAAoAAAAAwIGAGAAAAADAQgAYAAAAAEBCwABKgIDAg4CAQIkAwIDKgID AgEEAwQkAwQFaAwFBgAFB2gMBwggCAkABwpoDAoLaAwLDCgCCw1oDAAOJAQO DyoCAwIAEA8QBAQQEQAREgASEwASFAAUFQAVFgAUFwAXGAAYGQAYGgAaGwAb HCAcHQAcHigCGB8AHyAADQRoDB8QABoSAEIDAAAABgUHCgsNBAYREhoYHxAF FBIaGBcXBAAAAAAAAAAW 2026-09-19T04:00:54Z