3811 Enniatin A1 Enniatin A1 is an exogenous solid with the chemical formula C35H61N3O9. Enniatin A1 belongs to the depsipeptides, a subclass of peptidomimetics within the organic compounds. With an average molecular weight of 667.87 g/mol, Enniatin A1 is a heavy molecule. This compound is found in or released from 13 recorded sources across several sectors. These include Electrical & Electronic Equipment, such as batteries, cell phones, capacitors, wires and cables, and printed circuit boards; Textiles, leather & furnishings, including carpets, rugs, and synthetic textiles; Food, food processing & cookware via food packaging; Healthcare, pharmaceuticals & veterinary products through medical devices; and Lubricants within the Energy, oil & gas and Industrial manufacturing & chemical processing sectors. Recorded exposure routes include touch, oral, and inhalation. Enniatin A1 interacts with four recorded protein targets. It inhibits acyl coenzyme A:cholesterol acyltransferase, specifically targeting Sterol O-acyltransferase 1 (SOAT1) and Sterol O-acyltransferase 2 (SOAT2). Additionally, it inhibits the activity of membrane-located ATP-binding cassette (ABC) transporters, including the ATP-dependent translocase ABCB1 and the broad substrate specificity ATP-binding cassette transporter ABCG2; these multidrug pumps affect the bioavailability of pharmaceuticals and xenobiotics. Enniatin A1 is also cytotoxic and can cause DNA fragmentation through an unnamed protein. 4530-21-6 16727692 C35H61N3O9 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Enniatins are toxic due to their ability to act as ionophores, changing ion transport across membranes and disrupting the ionic selectivity of cell walls. In the membrane, enniatins form a dimeric structure and are able to transport monovalent ions (especially K+, Mg2+,Ca2+ and Na+) across the membranes. This effect is particularly harmful in mitochondrial membranes, resulting in the uncoupling of oxidative phosphorylation. They are also know to inhibit several enzymes, including acyl coenzyme A:cholesterol acyltransferase and cyclic nucleotide phosphodiesterase. Enniatins are cytotoxic and can cause DNA fragmentation, induce apoptosis, and disrupt the ERK signalling pathway. They can also inhibit the activity of membrane-located ATP-binding cassette (ABC) transporters, multidrug pumps which affect the bioavailability of xenobiotics and pharmaceuticals. (A3055, A3056, A3057) No indication of carcinogenicity to humans (not listed by IARC). Enniatins are mycotoxins that appear in nature as a mixture of cyclohexadepsipeptides produced by bacteria, fungi, and plants. They may be found in contaminated cereal crops. (L1965, A3055) Enniatins are cytotoxic. They may also act as antifungal and antibacterial agents, and immunomodulatory substances. (A3055) 2010-05-18T15:31:20Z 2026-04-06T02:25:40Z http://en.wikipedia.org/wiki/Enniatin true CCCCC1N(C)C(=O)C(OC(=O)C(C(C)CC)N(C)C(=O)C(OC(=O)C(C(C)C)N(C)C(=O)C(OC1=O)C(C)C)C(C)C)C(C)C C35H61N3O9 InChI=1S/C35H61N3O9/c1-15-17-18-24-33(42)45-28(21(7)8)31(40)37(13)25(19(3)4)34(43)46-29(22(9)10)32(41)38(14)26(23(11)16-2)35(44)47-27(20(5)6)30(39)36(24)12/h19-29H,15-18H2,1-14H3 VGOLHAPJYMAXRH-UHFFFAOYSA-N 667.8735 667.440780565 Exogenous Solid 28184660 CHEM002725 DTXSID50891864 NS00094903 139.83000000000004 175.9301000000001 73.22435589071054 9 6 0 18.802691322391123 -5.478968687941619 0 1 4.39 -4.73 1.24e-02 g/l Organic compounds Organic acids and derivatives Peptidomimetics Depsipeptides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 776t3gAAAAAQAAAAAwAAAAAAAAAvAAAALwAAAIABBgBgAAAAAQMGAGAAAAAC AgYAYAAAAAICBgBgAAAAAgIGAGAAAAADAQcAKAAAAAMDBgBgAAAAAQMGACgA AAADBAgAKAAAAAMCBgBgAAAAAwEIACgAAAADAgYAKAAAAAMECAAoAAAAAwIG AGAAAAADAQYAYAAAAAMBBgBgAAAAAQMGAGAAAAACAgYAYAAAAAEDBwAoAAAA AwMGAGAAAAABAwYAKAAAAAMECAAoAAAAAwIGAGAAAAADAQgAKAAAAAMCBgAo AAAAAwQIACgAAAADAgYAYAAAAAMBBgBgAAAAAwEGAGAAAAABAwYAYAAAAAED BwAoAAAAAwMGAGAAAAABAwYAKAAAAAMECAAoAAAAAwIGAGAAAAADAQgAKAAA AAMCBgAoAAAAAwQIACgAAAADAgYAYAAAAAMBBgBgAAAAAQMGAGAAAAABAwYA YAAAAAMBBgBgAAAAAQMGAGAAAAABAwYAYAAAAAMBBgBgAAAAAQMGAGAAAAAB AwsAAQABAgACAwADBAAEBQAFBgAFByAHCCgCBwkACQoACgsgCwwoAgsNAA0O AA4PAA4QABARAA0SABITABIUIBQVKAIUFgAWFwAXGCAYGSgCGBoAGhsAGxwA Gx0AGh4AHh8AHiAgICEoAiAiACIjACMkICQlKAIiJgAmJwAmKAAWKQApKgAp KwAJLAAsLQAsLgAkBABCAQAAABIEJCMiIB4aGBcWFBINCwoJBwUXBAAAAAAA AAAW 2026-09-19T04:00:54Z