3820 Janthitrem G Janthitrem G is an exogenous solid with the chemical formula C39H51NO6. Janthitrem G belongs to the naphthopyrans, a class of organoheterocyclic compounds within the organic compounds. With an average molecular weight of 629.83 g/mol, Janthitrem G is a heavy molecule. This tremorgenic mycotoxin is produced by Penicillium janthinellum. It has 22 recorded protein targets, including mitochondrial 4-aminobutyrate aminotransferase (ABAT) and Gamma-aminobutyric acid receptor subunits alpha-1 (GABRA1), alpha-2 (GABRA2), and alpha-3 (GABRA3), among 18 other proteins. Tremorgenic mycotoxins are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This mechanism would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, and subsequently lead to decreased levels of neurotransmitter in the synapse. 90986-51-9 10394234 C39H51NO6 629.8 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. (A2976) No indication of carcinogenicity to humans (not listed by IARC). Janthitrems are tremorgenic mycotoxins that have been found in the fungus Penicillium janthinellum. They may be found in contaminated cereal crops such as oats, barley, millet, corn and rice. (A2976, A3065) Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as "staggers syndrome". (A2976) Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors, hyperexcitability, convulsions and ataxia. (A2976) To control severe tremors caused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744) 2010-05-20T15:21:17Z 2026-08-22T12:15:30Z true CC(=O)OC1C=C2C(CCC3(C)C4(C)C(CC5=C4NC4=C5C=C5CC6C(=CC(C)(C)OC6(C)C)C5=C4)CCC23O)OC1C(C)(C)O C39H51NO6 InChI=1S/C39H51NO6/c1-20(41)44-31-18-28-30(45-33(31)35(4,5)42)11-12-37(8)38(9)22(10-13-39(28,37)43)16-25-24-14-21-15-27-26(19-34(2,3)46-36(27,6)7)23(21)17-29(24)40-32(25)38/h14,17-19,22,27,30-31,33,40,42-43H,10-13,15-16H2,1-9H3 PGYSJEQVCATFBQ-UHFFFAOYSA-N 629.8253 629.371638369 Exogenous Solid 4.2 HMDB30531 8569675 CHEM002733 NS00124342 [12-hydroxy-8-(2-hydroxypropan-2-yl)-2,3,23,23,25,25-hexamethyl-7,24-dioxa-31-azaoctacyclo[15.14.0.02,15.03,12.06,11.018,30.020,28.022,27]hentriaconta-1(17),10,18(30),19,26,28-hexaen-9-yl] acetate 101.01000000000002 178.79439999999997 74.82651436296125 3 5 3 13.611570040393485 -3.1357150032455516 0 8 6.16 -6.40 2.48e-04 g/l Organic compounds Organoheterocyclic compounds Naphthopyrans 4 CED0022840 PGYSJEQVCATFBQ-UHFFFAOYSA-N 100400000000400800210000000000000000000000000001000000000000004000000000200000a040000002800000010000400000000400000000004480000000000000000000000000000820800000000140000050000000000000041000010004000010000000100000100002020000000080000000081000500010000048000000000000210200000028200000000000000000080000200020000000000004000048040000080000000000800000000000000200000080000000000000000000000800000000004000000008000000000020004000020008c00000008100000000010040000000080440000002002000000000000420001000 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 776t3gAAAAAQAAAAAwAAAAAAAAAuAAAANQAAAIABBgBgAAAAAQMGACgAAAAD BAgAKAAAAAMCCAAoAAAAAwIGAGAAAAADAQYAaAAAAAMDAQYAKAAAAAMEBgBg AAAAAwEGAGAAAAACAgYAYAAAAAICBgAgAAAABAYAYAAAAAEDBgAgAAAABAYA YAAAAAEDBgBgAAAAAwEGAGAAAAACAgZAKAAAAAMEBkAoAAAAAwQHQDgAAAAD AQMGQCgAAAADBAZAKAAAAAMEBkBoAAAAAwMBBkAoAAAAAwQGAGAAAAACAgYA YAAAAAMBBgAoAAAAAwQGAGgAAAADAwEGACAAAAAEBgBgAAAAAQMGAGAAAAAB AwgAIAAAAAIGACAAAAAEBgBgAAAAAQMGAGAAAAABAwZAKAAAAAMEBkBoAAAA AwMBBgBgAAAAAgIGAGAAAAACAgYAIAAAAAQIAGAAAAABAQgAIAAAAAIGAGAA AAADAQYAIAAAAAQGAGAAAAABAwYAYAAAAAEDCABgAAAAAQELAAEAAQIoAgED IAMEAAQFAAUGCAIGBwAHCAAICQAJCgAKCwAKDAAMDQAMDgAODwAPEAAQEWgM ERJoDBITaAwTFGgMFBVoDBUWaAwWFwAXGAAYGQAZGigCGhsAGxwAGx0AGx4A Hh8AHyAAHyEAGSIgIiNoDA4kACQlACUmACYnAAcoACgpACkqACorACosACot ACkEACYGACYKABEMACMTaAwUEGgMIhZoDB8YAEIIAAAABgQpKAcGBQYICQom BgcFDw4MERAFEhEQFBMGFRYiIxMUBRcWIhkYBhobHh8YGQYkJSYKDA4XBAAA AAAAAAAW 2026-09-19T04:00:55Z