3822 Luteoskyrin Luteoskyrin is an exogenous solid compound with the chemical formula C30H22O12. Luteoskyrin belongs to the naphthols and derivatives, a subclass of naphthalenes within the organic compounds. With an average molecular weight of 574.49 g/mol, Luteoskyrin is a heavy molecule. This compound is hepatocarcinogenic and hepatotoxic. Its hepatocarcinogenic effects may result from its ability to induce DNA fragmentation. Luteoskyrin can bind to DNA, forming chelate-complexes with nucleic acids and select metal ions. Furthermore, it can inhibit the replication, transcription, and repair of DNA. This inhibitory action is at least partially due to the inhibition of ribonuclease H as well as RNA polymerase I and II. 21884-44-6 30840 C30H22O12 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Luteoskyrin is hepatotoxic. It is thought that this is a result of its metabolic reduction to the semiquinone radical catalyzed by NADPH-dependent cytochrome reductases in the liver, leading to the generation of active oxygen species in redox systems. This causes the induction of lipid peroxidation, hepatocellular membrane damage, and elevation of serum transaminase activities, resultin in liver injuries. Luteoskyrin is also hepatocarcinogenic, possibly a result of its ability to induce DNA fragmentation. It is able to bind to DNA, forming chelate-complexes with nucleic acids and select metal ions. Luteoskyrin inhibits the replication, transcription and repair of DNA, which is at least partially because it inhibits RNA polymerase and ribonuclease H. (A2955, A3042, A3070, A3071, A3072) Luteoskyrin accumulates selectively in the liver, with minor distribution to the serum and kidneys. In the liver it is reduced to its semiquinone radical by NADPH-dependent cytochrome reductases. (A3070,A3071) 145 mg/kg subcutaneously and 221 mg/kg orally in mice. (A3069) 3, not classifiable as to its carcinogenicity to humans. (L135) Luteoskyrin is a mycotoxin produced by the fungus Penicillium islandicum. It is known to be a storage mold contaminant of rice. (A3069) Luteoskyrin is hepatotoxic and hepatocarcinogenic, causing hepatic disorders such as liver cirrhosis and liver tumors. (A3069, A3070) 2010-05-21T14:46:10Z 2026-04-03T17:45:28Z true CC1=CC(O)=C2C(O)=C3C(=O)C4C(O)C5C6C(O)C(C(=O)C7=C(O)C8=C(O)C=C(C)C(O)=C8C(=O)C467)C35C(=O)C2=C1O C30H22O12 InChI=1S/C30H22O12/c1-5-3-7(31)9-11(19(5)33)27(41)29-13-14-24(38)17(29)26(40)16-22(36)10-8(32)4-6(2)20(34)12(10)28(42)30(14,16)18(23(13)37)25(39)15(29)21(9)35/h3-4,13-14,17-18,23-24,31-38H,1-2H3 FAZDYVMEXQHRLI-UHFFFAOYSA-N 574.4885 574.111126168 Exogenous Solid 28613 CHEM002735 DTXSID0020787 NS00026980 230.11999999999995 143.68880000000001 54.87610768349246 0 12 8 5.566740446371182 -4.338395485455224 -2 8 1.74 -2.50 1.84e+00 g/l Organic compounds Benzenoids Naphthalenes Naphthols and derivatives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 776t3gAAAAAQAAAAAwAAAAAAAAAqAAAAMQAAAIABBgBgAAAAAQMGQCgAAAAD BAZAaAAAAAMDAQZAKAAAAAMECABoAAAAAwEBBkAoAAAAAwQGACgAAAADBAgA aAAAAAMBAQYAKAAAAAMEBgAoAAAAAwQIACgAAAADAgYAYAAAAAMBBgBgAAAA AwEIAGAAAAABAQYAYAAAAAMBBgBgAAAAAwEGAGAAAAADAQgAYAAAAAEBBgBg AAAAAwEGACgAAAADBAgAKAAAAAMCBgAoAAAAAwQGACgAAAADBAgAaAAAAAMB AQZAKAAAAAMEBkAoAAAAAwQIAGgAAAADAQEGQGgAAAADAwEGQCgAAAADBAYA YAAAAAEDBkAoAAAAAwQIAGgAAAADAQEGQCgAAAADBAYAKAAAAAMECAAoAAAA AwIGACAAAAAEBgAgAAAABAYAKAAAAAMECAAoAAAAAwIGQCgAAAADBAZAKAAA AAMECABoAAAAAwEBCwABAAECaAwCA2gMAwQgAwVoDAUGIAYHIAYIKAIICSAJ CigCCQsACwwADA0ADA4ADg8ADxAAEBEAEBIAEhMAExQoAhMVIBUWKAIWFyAW GCAYGWgMGRogGRtoDBscaAwcHQAcHmgMHh8gHiBoDCAhICEiKAIhIwASJAAk JQAlJigCJScgJyhoDCgpICgBaAwnBWgMJAgAIwsAJA4AIw8AIxUAIBhoDEII AAAABgEoJwUDAgYGCCQlJwUGCQsMDiQIBQwLIw8OBRAPDiQSBhMVIw8QEgYW GCAhIxUGGRscHiAYFwQAAAAAAAAAFg== 2026-09-19T04:00:55Z