3835 Verrucosidin Verrucosidin is a solid exogenous organic compound with the formula C24H32O6 and an average molecular weight of 416.51 g/mol. Verrucosidin belongs to the pyranones and derivatives, a subclass of pyrans within the organic compounds. This compound is associated with 22 recorded protein targets, including 4-aminobutyrate aminotransferase, mitochondrial (ABAT), as well as Gamma-aminobutyric acid receptor subunits alpha-1 (GABRA1), alpha-2 (GABRA2), and alpha-3 (GABRA3). Tremorgenic mycotoxins are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This mechanism would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, and subsequently lead to decreased levels of neurotransmitter in the synapse. Additionally, verrucosidin is genotoxic and causes DNA damage. 88389-71-3 6437365 C24H32O6 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. Verrucosidin is also genotoxic and causes DNA damage. (A2976, A3026) No indication of carcinogenicity to humans (not listed by IARC). Verrucosidin is a tremorgenic mycotoxin that has been found in fungi of the genera Penicillium and Aspergillus. It may be found in contaminated cereal crops such as oats, barley, millet, corn and rice. (A2976) Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as "staggers syndrome". (A2976) Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors, hyperexcitability, convulsions and ataxia. (A2976) To control severe tremors caused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744) 2010-06-10T15:41:05Z 2026-04-06T11:59:40Z true [H]\C(\C(\C)=C(/[H])C1(C)OC(C)C2(C)OC12)=C(\C)C1OC1(C)C1=C(C)C(OC)=C(C)C(=O)O1 C24H32O6 InChI=1S/C24H32O6/c1-12(11-22(6)21-23(7,30-21)16(5)28-22)10-13(2)18-24(8,29-18)19-14(3)17(26-9)15(4)20(25)27-19/h10-11,16,18,21H,1-9H3/b12-11+,13-10+ JSVLNARHSWZARV-JASOSIDASA-N 416.514 416.21988875 Exogenous Solid CHEM002745 NS00122654 69.82000000000001 115.5577 45.76278913818702 5 5 0 -3.7595583304774327 0 4 4.53 -4.49 1.34e-02 g/l Organic compounds Organoheterocyclic compounds Pyrans Pyranones and derivatives 115 CED0018248 JSVLNARHSWZARV-JASOSIDASA-N 2000000000000000041000000000000040000040040000000008000080000000002000040000000000000000040000000400000100000000000000000000000000000000000000000000002080000000030000000000000800400000000001000040004000200000000000800000000000000000000000000050000008024802000000000000800000000000000000000000200000002000002000000004000000000000000009000000000000001000000800000000000000008000000000000081080200010000000000000000000000a000020000000000000010080000000000000000000000000000000000000000000000000020000000 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 776t3gAAAAAQAAAAAwAAAAAAAAAeAAAAIQAAAIABBgA4AAAAAwEEBgAoAAAA AwQGAGAAAAABAwYAOAAAAAMBBAYAIAAAAAQGAGAAAAABAwgAIAAAAAIGAGAA AAADAQYAYAAAAAEDBgAgAAAABAYAYAAAAAEDCAAgAAAAAgYAYAAAAAMBBgAo AAAAAwQGAGAAAAABAwYAYAAAAAMBCAAgAAAAAgYAIAAAAAQGAGAAAAABAwZA KAAAAAMEBkAoAAAAAwQGAGAAAAABAwZAKAAAAAMECAAoAAAAAwIGAGAAAAAB AwZAKAAAAAMEBgBgAAAAAQMGQCgAAAADBAgAKAAAAAMCCEAoAAAAAwILAAEk AwECBAMBAyoCAwIABAMEBAMEBQAEBgAGBwAHCAAHCQAJCgAJCwALDAAADSoC AwIBDw0OBAMNDwAPEAAQEQAREgAREwATFGgMFBUAFBZoDBYXIBcYABYZaAwZ GgAZG2gMGxwoAhsdaAwMBAARDwAdE2gMDAkAQgQAAAAFBgQMCQcDCwkMAxAP EQYUFhkbHRMXBAAAAAAAAAAW 2026-09-19T04:00:55Z