3866 Clofentezine Clofentezine is an exogenous organic compound with the formula C14H8Cl2N4 and an average molecular weight of 303.15 g/mol. At room temperature, it exists as a solid. Clofentezine belongs to the halobenzenes, a subclass of benzene and substituted derivatives within the organic compounds. Functioning as a tetrazine acaricide, this compound is used as a mite growth regulator. It has been recorded in five sources, including pesticides in agriculture and land management, drinking water and water supply, and food, food processing and cookware, specifically in the preparation of malt, the preparation of wine or sparkling wine, and molasses and the treatment of molasses. Exposure routes include oral, inhalation, and touch. In biological systems, clofentezine interacts with 15 recorded protein targets. These include the bile salt export pump (ABCB11), C-C motif chemokine 2 (CCL2), collagen alpha-1(III) chain (COL3A1), cytochrome P450 1A2 (CYP1A2), and 11 other proteins. 74115-24-5 73670 C14H8Cl2N4 303.1 White powder. Oral (rat) > 5200 mg/kg Dermal (rat) > 2100 mg/kg Inhalation (rat) > 0.89 (mg/l) Oral (rat) > 5200 mg/kg Dermal (rat) > 2100 mg/kg Inhalation (rat) > 0.89 (mg/l) Not listed by IARC. This is a man-made compound that is used as a pesticide. No adverse health effects attributable to clofentezine were detecte during medical surveillance between 1985 and 2004 in workers at a plant manufacturing clofentezine. The medical examination included an extensive physical examination (including height, body weight, skin, ear, nose and throat, and respiratory, nervous, alimentary, reticulo-endothelial and cardiovascular systems, and locomotion) and specific tests for blood pressure and vision. The examination also included tests for hearing, lung function, urine analysis and blood tests when these were considered appropriate. (Makhteshim Agan Industries Ltd, 2004). However, there is an increase of incidences of thyroid adenomas, adenocarcinomas, thyroid hyperplasia, agglomeration of colloid and thyroid hormones in rats receiving prolonged treatment of high dose of clofentezine. 2013-04-25T07:56:50Z 2026-08-19T08:18:52Z C18576 39315 true ClC1=CC=CC=C1C1=NN=C(N=N1)C1=CC=CC=C1Cl C14H8Cl2N4 InChI=1S/C14H8Cl2N4/c15-11-7-3-1-5-9(11)13-17-19-14(20-18-13)10-6-2-4-8-12(10)16/h1-8H UXADOQPNKNTIHB-UHFFFAOYSA-N 303.146 302.01260169 Exogenous Solid CHEMBL17888 66321 CHEM002772 DTXSID9023881 NS00005836 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine 51.56 103.8588 29.020642375683046 2 4 0 -4.6209100129222485 0 3 3.40 -4.07 2.59e-02 g/l Organic compounds Benzenoids Benzene and substituted derivatives Halobenzenes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 776t3gAAAAAQAAAAAwAAAAAAAAAUAAAAFgAAAIABEQAgAAAAAQZAKAAAAAME BkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMBBkAoAAAAAwQG QCgAAAADBAdAKAAAAAMDB0AoAAAAAwMGQCgAAAADBAdAKAAAAAMDB0AoAAAA AwMGQCgAAAADBAZAaAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMD AQZAKAAAAAMEEQAgAAAAAQsAAQABAmgMAgNoDAMEaAwEBWgMBQZoDAYHIAcI aAwICWgMCQpoDAoLaAwLDGgMCg0gDQ5oDA4PaAwPEGgMEBFoDBESaAwSEwAG AWgMDAdoDBINaAxCAwAAAAYBBgUEAwIGCAkKCwwHBg4PEBESDRcEAAAAAAAA ABY= 2026-09-19T04:00:56Z