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<compound>
  <id type="integer">4018</id>
  <title>T3D3964</title>
  <common-name>Daidzein</common-name>
  <description>Daidzein (C15H10O4) is a solid with an average molecular weight of 254.24 g/mol. Daidzein belongs to the isoflav-2-enes, a subclass of isoflavonoids within the organic compounds. This exogenous plant metabolite functions as a phytoestrogen, an agonist (PMC3515069), and an inhibitor of DNA-directed DNA polymerase (EC 2.7.7.7). Its industrial applications include use as a softener and conditioner, and it is utilized as an antineoplastic agent (PMC3515069).

The compound interacts with twelve recorded protein targets, including the Estrogen receptor (ESR1), Estrogen receptor beta (ESR2), Bile acid receptor (NR1H4), and Aryl hydrocarbon receptor (AHR). Regarding health effects, daidzein has a therapeutic effect on osteoporosis, cancer (PMC5037818), breast cancer (PMC8395949), and prostate cancer (PMC8395949). It is associated with a decrease in endometrial cancer (PMC11303474) and prostate cancer (PMC3134227).

Daidzein is found in 19 recorded sources across several sectors. These include electrical and electronic equipment such as batteries, capacitors, cell phones, printed circuit boards, and wires and cables; food, food processing and cookware, specifically food packaging and the preparation of vinegar, wort, and wine or sparkling wine, as well as the treatment of hops; textiles, leather and furnishings, including synthetic textiles and carpets and rugs; drinking water and water supply; healthcare, pharmaceuticals and veterinary products via medical devices; and energy, oil and gas through lubricants. Recorded exposure routes for the compound are oral, inhalation, and touch.</description>
  <cas>486-66-8</cas>
  <pubchem-id>5281708</pubchem-id>
  <chemical-formula>C15H10O4</chemical-formula>
  <weight nil="true"/>
  <appearance>White powder.</appearance>
  <melting-point>323°C</melting-point>
  <boiling-point></boiling-point>
  <density nil="true"/>
  <solubility></solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure nil="true"/>
  <target nil="true"/>
  <mechanism-of-toxicity nil="true"/>
  <metabolism nil="true"/>
  <toxicity nil="true"/>
  <lethaldose nil="true"/>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use-source>Isoflavones compounds are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Equol represents the main active product of daidzein metabolism, produced via specific microflora in the gut.</use-source>
  <min-risk-level nil="true"/>
  <health-effects nil="true"/>
  <symptoms nil="true"/>
  <treatment nil="true"/>
  <created-at type="dateTime">2014-08-29T04:47:45Z</created-at>
  <updated-at type="dateTime">2026-05-14T19:30:52Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia nil="true"/>
  <uniprot-id nil="true"/>
  <kegg-compound-id>C10208</kegg-compound-id>
  <omim-id nil="true"/>
  <chebi-id>28197</chebi-id>
  <biocyc-id>2-HYDROXYDAIDZEIN</biocyc-id>
  <ctd-id nil="true"/>
  <stitch-id nil="true"/>
  <drugbank-id>DB13182</drugbank-id>
  <pdb-id nil="true"/>
  <actor-id nil="true"/>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles>OC1=CC=C(C=C1)C1=COC2=C(C=CC(O)=C2)C1=O</moldb-smiles>
  <moldb-formula>C15H10O4</moldb-formula>
  <moldb-inchi>InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H</moldb-inchi>
  <moldb-inchikey>ZQSIJRDFPHDXIC-UHFFFAOYSA-N</moldb-inchikey>
  <moldb-average-mass type="decimal">254.241</moldb-average-mass>
  <moldb-mono-mass type="decimal">254.057908802</moldb-mono-mass>
  <origin>Exogenous</origin>
  <state>Solid</state>
  <logp>2.73</logp>
  <hmdb-id>HMDB03312</hmdb-id>
  <chembl-id>CHEMBL8145</chembl-id>
  <chemspider-id>4445025</chemspider-id>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference>Baker, Wilson; Robinson, Robert; Simpson, N. M.  Synthetical experiments in the isoflavone group. VII. Synthesis of daidzein.    Journal of the Chemical Society  (1933),     274-5.</synthesis-reference>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM002924</chemdb-id>
  <dsstox-id>DTXSID9022310</dsstox-id>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id>NS00010903</susdat-id>
  <iupac>7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one</iupac>
  <moldb-polar-surface-area>66.76</moldb-polar-surface-area>
  <moldb-refractivity>69.70200000000001</moldb-refractivity>
  <moldb-polarizability>25.749073574949946</moldb-polarizability>
  <moldb-rotatable-bond-count>1</moldb-rotatable-bond-count>
  <moldb-acceptor-count>4</moldb-acceptor-count>
  <moldb-donor-count>2</moldb-donor-count>
  <moldb-pka-strongest-acidic>6.476840159725478</moldb-pka-strongest-acidic>
  <moldb-pka-strongest-basic>-5.336102454110623</moldb-pka-strongest-basic>
  <moldb-physiological-charge>-1</moldb-physiological-charge>
  <moldb-number-of-rings>3</moldb-number-of-rings>
  <moldb-alogps-logp>3.30</moldb-alogps-logp>
  <moldb-alogps-logs>-3.48</moldb-alogps-logs>
  <moldb-alogps-solubility>8.49e-02 g/l</moldb-alogps-solubility>
  <kingdom>Organic compounds</kingdom>
  <superklass>Phenylpropanoids and polyketides</superklass>
  <klass>Isoflavonoids</klass>
  <subklass>Isoflav-2-enes</subklass>
  <paper-count type="integer">4789</paper-count>
  <sync-id>CED0002745</sync-id>
  <structure-inchikey>ZQSIJRDFPHDXIC-UHFFFAOYSA-N</structure-inchikey>
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  <structure-indexed-at type="dateTime">2026-09-19T04:01:02Z</structure-indexed-at>
</compound>
