4025 1-Hydroxypyrene 1-Hydroxypyrene (C16H12O) is an organic compound with an average molecular weight of 220.27 g/mol. It exists as a solid at room temperature and is of exogenous origin. 1-Hydroxypyrene belongs to the phenanthrols, a subclass of phenanthrenes and derivatives within the organic compounds. This compound is a metabolite of pyrene found in urine. It serves as an accepted biomarker for the dose of carcinogenic polycyclic aromatic hydrocarbons (PAH). PAHs constitute a diverse group of environmental carcinogens that form during the incomplete combustion of organic matter and are believed to play an important role as causes of human cancer, especially in cigarette smokers and certain occupational settings. There are 11 recorded protein targets for 1-hydroxypyrene. These include the estrogen receptor (ESR1), cytochrome P450 1A2 (CYP1A2), cytochrome P450 2C9 (CYP2C9), and the 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1), along with 7 other proteins. 5315-79-7 53481631 C16H12O White powder. 180°C No indication of carcinogenicity to humans (not listed by IARC). This is a toxic chemical found in cigarettes or generated by tobacco combustion. 2014-08-29T04:48:18Z 2026-04-02T23:29:43Z C14519 true OC1C=CC2=CCC3=C4C(C=CC1=C24)=CC=C3 C16H12O InChI=1S/C16H12O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-3,5-9,14,17H,4H2 CDYIVSAQQUIYKS-UHFFFAOYSA-N 220.2659 220.088815006 Exogenous Solid HMDB13139 20100 CHEM002931 DTXSID1038298 NS00014602 20.23 71.1061 24.35918496452651 0 1 1 13.96419436934368 -3.2518613828490732 0 4 3.43 -4.11 1.73e-02 g/l Organic compounds Benzenoids Phenanthrenes and derivatives Phenanthrols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 776t3gAAAAAQAAAAAwAAAAAAAAARAAAAFAAAAIABCABgAAAAAQEGAGAAAAAD AQYAaAAAAAMDAQYAaAAAAAMDAQYAKAAAAAMEBgBoAAAAAwMBBgBgAAAAAgIG QCgAAAADBAZAKAAAAAMEBkAoAAAAAwQGQGgAAAADAwEGQGgAAAADAwEGQCgA AAADBAZAKAAAAAMEBkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMBCwABAAEC AAIDKAIDBCAEBSgCBQYABgcABwhoDAgJaAwJCmgMCgtoDAsMaAwMDWgMCQ5o DA4PaAwPEGgMDAEADQQgEAdoDA0IaAxCBAAAAAYBDA0EAwIGBQYHCA0EBgoL DA0ICQYODxAHCAkXBAAAAAAAAAAW 2026-09-19T04:01:03Z