4050 Dimethylthiophosphate Dimethylthiophosphate is an exogenous organic compound with the formula C2H7O3PS and an average molecular weight of 142.11 g/mol. It exists as a solid at room temperature. Dimethylthiophosphate belongs to the thiophosphoric acid esters, a subclass of organic thiophosphoric acids and derivatives within the organic compounds. This substance is further classified under the superclass of organic acids and derivatives. Regarding its biochemical interactions, one recorded protein target for this compound is phosphotriesterase (opdA). 59401-04-6 3539116 C2H7O3PS 142.12 White powder. Metabolism of organophosphates occurs principally by oxidation, by hydrolysis via esterases and by reaction with glutathione. Demethylation and glucuronidation may also occur. Oxidation of organophosphorus pesticides may result in moderately toxic products. In general, phosphorothioates are not directly toxic but require oxidative metabolism to the proximal toxin. The glutathione transferase reactions produce products that are, in most cases, of low toxicity. Paraoxonase (PON1) is a key enzyme in the metabolism of organophosphates. PON1 can inactivate some organophosphates through hydrolysis. PON1 hydrolyzes the active metabolites in several organophosphates insecticides as well as, nerve agents such as soman, sarin, and VX. The presence of PON1 polymorphisms causes there to be different enzyme levels and catalytic efficiency of this esterase, which in turn suggests that different individuals may be more susceptible to the toxic effect of organophosphate exposure. No indication of carcinogenicity to humans (not listed by IARC). 2014-08-29T04:48:50Z 2026-08-22T09:59:20Z DB04687 true COP(O)(=S)OC C2H7O3PS InChI=1S/C2H7O3PS/c1-4-6(3,7)5-2/h1-2H3,(H,3,7) WWJJVKAEQGGYHJ-UHFFFAOYSA-N 142.114 141.985351292 Exogenous Solid 0.7 2777580 CHEM002956 DTXSID10858736 NS00067290 hydroxy-dimethoxy-sulfanylidene-lambda5-phosphane 38.69 31.607400000000002 11.844783762502907 2 1 1 2.8595944005744904 -1 0 0.33 -1.16 9.93e+00 g/l Organic compounds Organic acids and derivatives Organic thiophosphoric acids and derivatives Thiophosphoric acid esters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c000100004420008000008051040000000100000000000062000000000000400000220000004000000120040000000040000000000000401000002000801080000004110800000010000200400008040404000800020008000000100400124400100000000a00000000004241000000004000000008000020001002c0000000000800100001000000000008004000040000020000000000000080000000000000400000002000080000000000000000000000000000000000000000000000404000000000000050000000 ï¾­Þ������������������������€���`������� ������ ������`�������(������� ������`�������������������������B�������������� 2026-09-19T04:01:03Z