4072 Ouabain Ouabain is an exogenous solid with the chemical formula C29H44O12. Ouabain belongs to the steroid lactones, a subclass of steroids and steroid derivatives within the organic compounds. With an average molecular weight of 584.65 g/mol, Ouabain is a heavy molecule. This plant metabolite is used as a cardiotonic drug and an anti-arrhythmia drug. In biological and chemical contexts, ouabain functions as an ion transport inhibitor. It acts as an inhibitor for the Na(+)/K(+)-transporting ATPase (EC 3.6.3.9), the H(+)/K(+)-exchanging ATPase (EC 3.6.3.10), citrate (Si)-synthase (EC 2.3.3.1), and 4-nitrophenylphosphatase (EC 3.1.3.41). Its recorded protein targets include the alpha-1, alpha-2, and alpha-3 subunits of the sodium/potassium-transporting ATPase (ATP1A1, ATP1A2, and ATP1A3). Ouabain is found in three recorded sources: television systems within electrical and electronic equipment, and the preparation of vinegar, wine, or sparkling wine within food, food processing, and cookware. 630-60-4 439501 C29H44O12 White powder. 200°C 1.03E+004 mg/L Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential. No indication of carcinogenicity to humans (not listed by IARC). For the treatment of atrial fibrillation and flutter and heart failure 2014-08-29T04:49:16Z 2026-05-14T16:57:45Z Ouabain C01443 472805 DB01092 OBN true [H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]1(C)[C@H](CC[C@]21O)C1=CC(=O)OC1)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O C29H44O12 InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1 LPMXVESGRSUGHW-HBYQJFLCSA-N 584.6525 584.283276872 Exogenous Solid -2 HMDB15224 CHEMBL222863 388599 CHEM002978 DTXSID0043765 NS00003260 4-[(1R,3aS,3bR,5aS,7S,9R,9aR,9bS,10R,11aR)-3a,5a,9,10-tetrahydroxy-9a-(hydroxymethyl)-11a-methyl-7-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2,5-dihydrofuran-2-one 206.59999999999997 140.83379999999994 59.92556829434825 4 11 8 7.181446894362235 -2.8503841755458543 0 6 -1.03 -2.10 4.61e+00 g/l Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Steroid lactones 19311 CED0002282 LPMXVESGRSUGHW-HBYQJFLCSA-N 4010008800000401000000001000000000000000020000000000000000000000600800000000000000200000000000004000000000004000000100400002000000000000004000000004208000012001100000200000000080000000000100000000004000040000000000000200000000000000000000c01000040000480000000040000000200000202000000000000000000000004000200108000400140000000080000c8000000400000800200000000140000004000000000000000000020000000000000000000000000000000000000000000000002880008004004000000040000002000041002002000080000000000000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAApAAAALgAAAIABBiA0AAAAAgEEBgBgAAAA AgIGAGAAAAACAgYgJAAAAAIECABgAAAAAQEGAGAAAAACAgYgNAAAAAIBBAYA YAAAAAICBiA0AAAAAQEECABgAAAAAQEGICQAAAACBAYAYAAAAAICCABgAAAA AQEGIDQAAAABAQQGIDQAAAACAQQIAGAAAAABAQYAYAAAAAICBiAkAAAAAgQG AGAAAAABAwYgNAAAAAIBBAYAYAAAAAICBgBgAAAAAgIGICQAAAABBAgAYAAA AAEBBgAoAAAAAwQGAGgAAAADAwEGACgAAAADBAgAKAAAAAMCCAAoAAAAAwIG AGAAAAACAggAIAAAAAIGIDQAAAACAQQIACAAAAACBiA0AAAAAQEEBgBgAAAA AQMGIDQAAAACAQQIAGAAAAABAQYgNAAAAAEBBAgAYAAAAAEBBiA0AAAAAQEE CABgAAAAAQELAAEAAQIAAgMAAwQAAwUABQYABgcABwgACAkACAoACgsACwwA Cg0ADQ4ADg8ADhAAEBEAERIAERMAExQAFBUAFRYAFhcAExgAGBkoAhkaIBob KAIaHCAcHQAGHgAeHwAfIAAgIQAhIgAhIwAjJAAjJQAlJgAlJwAnKAANAAAW EQAdGAAnHwAWAAAKAwBCBgAAAAYBAgMKDQAGBQYHCAoDBg4QERYADQUUExEW FQUZGB0cGgYgISMlJx8XBAAAAAAAAAAW 2026-09-19T04:01:03Z