4104 alpha-Chaconine alpha-Chaconine is an exogenous solid with the chemical formula C45H73NO14. alpha-Chaconine belongs to the steroidal glycosides, a subclass of steroids and steroid derivatives within the organic compounds. With an average molecular weight of 852.06 g/mol, alpha-Chaconine is a heavy molecule. This compound is found in potato and is an alkaloid derived from Solanum chacoense and various other Solanum species of the Solanaceae family. It has been shown to exhibit anti-fungal and anti-angiogenic functions. alpha-Chaconine has been found in or released from 13 recorded sources across several sectors. These include healthcare, pharmaceuticals & veterinary products via medical devices; energy, oil & gas and industrial manufacturing & chemical processing through lubricants; food, food processing & cookware via food packaging; textiles, leather & furnishings including carpets, rugs, and synthetic textiles; and electrical & electronic equipment, including batteries, capacitors, printed circuit boards, cell phones, wires and cables, and one additional source. Recorded exposure routes for the compound include oral, touch, and inhalation. 20562-03-2 4115417 C45H73NO14 White powder. 243°C Alpha-Chaconine has inhibitory effect on lung adenocarcinoma cell metastasis in vitro. Alpha-chaconine could inhibit phosphorylation of c-Jun N-terminal kinase (JNK) and Akt, whereas it did not affected phosphorylation of extracellular signal regulating kinase (ERK) and p38. In addition, alpha-chaconine significantly decreased the nuclear level of nuclear factor kappa B (NF-_B) and the binding ability of NF-_B. Therefore, alpha-chaconine inhibited A549 cell metastasis by a reduction of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) activities involving suppression of phosphoinositide 3-kinase/Akt/NF-_B (PI3K/Akt/NF-_B) signaling pathway. Alpha-chaconine has exhibited its antiproliferative and apoptotic effects on the growth of cancer cells originating from human skin, liver, prostate, breast, and colon. In addition to the cytotoxicity in various cancer cells, R-chaconine induces significant cytotoxicity in Chang, normal human liver cells. (A15417) No indication of carcinogenicity to humans (not listed by IARC). alpha-Chaconine is found in potato. 2014-08-29T04:58:10Z 2026-04-06T01:49:50Z C10796 true CC1C2CCC(C)CN2C2CC3C4CC=C5CC(CCC5(C)C4CCC3(C)C12)OC1OC(CO)C(OC2OC(C)C(O)C(O)C2O)C(O)C1OC1OC(C)C(O)C(O)C1O C45H73NO14 InChI=1S/C45H73NO14/c1-19-7-10-28-20(2)31-29(46(28)17-19)16-27-25-9-8-23-15-24(11-13-44(23,5)26(25)12-14-45(27,31)6)57-43-40(60-42-37(53)35(51)33(49)22(4)56-42)38(54)39(30(18-47)58-43)59-41-36(52)34(50)32(48)21(3)55-41/h8,19-22,24-43,47-54H,7,9-18H2,1-6H3 TYNQWWGVEGFKRU-UHFFFAOYSA-N 852.0594 851.503106049 Exogenous Solid HMDB39353 3328941 CHEM003010 DTXSID501016601 NS00094322 220.45999999999995 215.00990000000004 96.30670834802265 7 15 8 12.218002600948315 11.784001120236216 1 9 1.87 -3.47 2.90e-01 g/l Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Steroidal glycosides 250 CED0010848 TYNQWWGVEGFKRU-UHFFFAOYSA-N 51080000400000000008000000001000000000000000000800000020100000000000000010000000800000001000000000000000000000000000000004000800100400002000000000002002002000000008004000001000010200110000000000000000100000000000000050000000001000201000000000000000100401000040000480004000040000000000008002000000000000000100000004004200008000400160000000000000c00024000000000000000000401200000080000000000000000000000080000000000000400004000000280000000000800040108000020000040000000400c0000000040000003000000400000000000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAA8AAAARAAAAIABBgBgAAAAAQMGAGAAAAAD AQYAYAAAAAMBBgBgAAAAAgIGAGAAAAACAgYAYAAAAAMBBgBgAAAAAQMGAGAA AAACAgcAIAAAAAMGAGAAAAADAQYAYAAAAAICBgBgAAAAAwEGAGAAAAADAQYA YAAAAAICBgBoAAAAAwMBBgAoAAAAAwQGAGAAAAACAgYAYAAAAAMBBgBgAAAA AgIGAGAAAAACAgYAIAAAAAQGAGAAAAABAwYAYAAAAAMBBgBgAAAAAgIGAGAA AAACAgYAIAAAAAQGAGAAAAABAwYAYAAAAAMBCAAgAAAAAgYAYAAAAAMBCAAg AAAAAgYAYAAAAAMBBgBgAAAAAgIIAGAAAAABAQYAYAAAAAMBCAAgAAAAAgYA YAAAAAMBCAAgAAAAAgYAYAAAAAMBBgBgAAAAAQMGAGAAAAADAQgAYAAAAAEB BgBgAAAAAwEIAGAAAAABAQYAYAAAAAMBCABgAAAAAQEGAGAAAAADAQgAYAAA AAEBBgBgAAAAAwEIACAAAAACBgBgAAAAAwEIACAAAAACBgBgAAAAAwEGAGAA AAABAwYAYAAAAAMBCABgAAAAAQEGAGAAAAADAQgAYAAAAAEBBgBgAAAAAwEI AGAAAAABAQsAAQABAgACAwADBAAEBQAFBgAFBwAHCAAICQAJCgAKCwALDAAM DQANDgAODwgCDxAAEBEAERIAEhMAExQAFBUAFBYAFhcAFxgAGBkAGRoAGRsA ERwAHB0AHR4AHh8AHyAAICEAHyIAIiMAIyQAJCUAJSYAJicAJigAKCkAKCoA KisAKiwALC0AIi4ALi8ALjAAMDEAMTIAMjMAMzQANDUANDYANjcANjgAODkA ODoAOjsAGwEAMB0AOjIACAIAGwkALCQAGQsAFgwAFA8AQgkAAAAFAQIICRsG AwQFBwgCBQoJGxkLBg0ODxQWDAYQERITFA8GFxgZCwwWBh4fIi4wHQYlJigq LCQGMzQ2ODoyFwQAAAAAAAAAFg== 2026-09-19T04:01:04Z