4121 Convallatoxin Convallatoxin is a solid compound with the chemical formula C29H42O10. Convallatoxin belongs to the steroid lactones, a subclass of steroids and steroid derivatives within the organic compounds. With an average molecular weight of 550.64 g/mol, Convallatoxin is a heavy molecule. This exogenous substance functions biologically as a metabolite and is applied as a vasodilator agent. The compound is found in 13 recorded sources across multiple sectors. Within healthcare, pharmaceuticals, and veterinary products, it is associated with medical devices. In the energy, oil, and gas sector, as well as industrial manufacturing and chemical processing, it is found in lubricants. It is also recorded in food packaging within the food, food processing, and cookware sector. Additionally, it appears in textiles, leather, and furnishings, specifically in carpets, rugs, and synthetic textiles. Its presence is further noted in electrical and electronic equipment, including batteries, capacitors, cell phones, printed circuit boards, wires, and cables, among one other sector. Recorded exposure routes for Convallatoxin include oral, inhalation, and touch. 508-75-8 441852 C29H42O10 White powder. Convallatoxin (CNT) is classified as a cardiac glycoside. Cardiac glycosides are well known Na+/K+-ATPase inhibitors, and some of them are used to treat congestive heart failure and atrial arrhythmias. Recent studies have reported that cardiac glycosides have potential as anticancer agents. CNT exerts cytotoxic effects on a number of cancer and normal cell lines and induces apoptosis by increasing caspase-3 and poly ADP ribose polymerase (PARP) cleavage. Moreover, dose- and time-dependent autophagic activity was detected in CNT-treated cells, and mammalian target of rapamycin (mTOR)/p70S6K signal pathway inhibition was observed. Notably, CNT inhibits human umbilical vein endothelial cell (HUVEC) growth and exerts anti-angiogenic activity in vitro and in vivo. (A15340) No indication of carcinogenicity to humans (not listed by IARC). Convallatoxin is a glycoside extracted from Convallaria majalis. Convallatoxin is also isolated from the trunk bark of Antiaris toxicaria (A15340). 2014-08-29T05:01:38Z 2026-03-26T23:03:41Z Convallatoxin C08858 CHEBI:27663 true [H][C@@]1(CC[C@]2(O)[C@]3([H])CC[C@]4(O)C[C@]([H])(CC[C@]4(C=O)[C@@]3([H])CC[C@]12C)O[C@]1([H])O[C@@]([H])(C)[C@]([H])(O)[C@@]([H])(O)[C@@]1([H])O)C1=CC(=O)OC1 C29H42O10 InChI=1S/C29H42O10/c1-15-22(32)23(33)24(34)25(38-15)39-17-3-8-27(14-30)19-4-7-26(2)18(16-11-21(31)37-13-16)6-10-29(26,36)20(19)5-9-28(27,35)12-17/h11,14-15,17-20,22-25,32-36H,3-10,12-13H2,1-2H3/t15-,17-,18+,19-,20+,22-,23+,24+,25-,26+,27-,28-,29-/m0/s1 HULMNSIAKWANQO-JQKSAQOKSA-N 550.6378 550.277797564 Exogenous Solid CHEMBL399336 390428 CHEM003027 NS00005101 162.98 136.78649999999996 58.081799561246896 4 9 5 7.182632190660242 0.26897033367503453 0 6 0.14 -3.03 5.18e-01 g/l Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Steroid lactones 128 CED0013797 HULMNSIAKWANQO-JQKSAQOKSA-N 4010000800000401000000000000000000000000000000000000000000000000600800000000000000000000000000004000000000004001000100400002100000080000004000000000208000012003100000200000000000000000000110000000000000040000000000000200000000000000000008801000040000480000000040000000000000202000000000000000000000004004200100000400140000000080000c0000000000000800200000400100000004400000000000000000020002000000000000000000000000000000000000200000000880000004004000000040400000001040000002000000000002000000000000 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 776t3gAAAAAQAAAAAwAAAAAAAAAnAAAALAAAAIABBiA0AAAAAgEEBgBgAAAA AgIGAGAAAAACAgYgJAAAAAIECABgAAAAAQEGIDQAAAACAQQGAGAAAAACAgYA YAAAAAICBiAkAAAAAgQIAGAAAAABAQYAYAAAAAICBiA0AAAAAgEEBgBgAAAA AgIGAGAAAAACAgYgJAAAAAIEBgBoAAAAAwMBCAAoAAAAAwIGIDQAAAABAQQG AGAAAAACAgYAYAAAAAICBiAkAAAAAgQGAGAAAAABAwgAIAAAAAIGIDQAAAAC AQQIACAAAAACBiA0AAAAAQEEBgBgAAAAAQMGIDQAAAACAQQIAGAAAAABAQYg NAAAAAEBBAgAYAAAAAEBBiA0AAAAAQEECABgAAAAAQEGACgAAAADBAYAaAAA AAMDAQYAKAAAAAMECAAoAAAAAwIIACgAAAADAgYAYAAAAAICCwABAAECAAID AAMEAAMFAAUGAAYHAAcIAAgJAAgKAAoLAAsMAAwNAA0OAA4PAA8QCAIOEQAR EgASEwATFAAUFQALFgAWFwAXGAAYGQAZGgAZGwAbHAAbHQAdHgAdHwAfIAAA IQAhIigCIiMgIyQoAiMlICUmABQAAB8XACYhABQDABEFAA4IAEIGAAAABQEA FAMCBgYHCA4RBQYKCwwNDggGEhMUAwURBhgZGx0fFwUiISYlIxcEAAAAAAAA ABY= 2026-09-19T04:01:05Z