4125 Gelsemine Gelsemine is a solid organic compound with the formula C20H22N2O2 and an average molecular weight of 322.40 g/mol. Gelsemine belongs to the gelsemium alkaloids, a class of alkaloids and derivatives within the organic compounds. This exogenous substance is found in or released from 14 recorded sources. These sources span several sectors, including electrical and electronic equipment such as batteries, capacitors, printed circuit boards, wires and cables, and cell phones. It is also found in textiles, leather and furnishings, specifically carpets, rugs, and synthetic textiles. Additionally, it is recorded in drinking water and water supply, food packaging within the food, food processing and cookware sector, medical devices in the healthcare, pharmaceuticals and veterinary products sector, and lubricants in the energy, oil and gas sector, among two other sectors. The recorded exposure routes for gelsemine include oral, inhalation, and touch. 509-15-9 5462429 C20H22N2O2 White powder. Gelsemine has convulsant effects with a similar mechanism of action to strychnine. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine receptors. It primarily affects the motor nerves in the spinal cord which control muscle contraction. An impulse is triggered at one end of a nerve by the binding of neurotransmitters to the receptors. In the presence of a neuroinhibitor, such as glycine, a greater quantity of excitatory neurotransmitters must bind to receptors before there will be an action potential generated. Glycine acts primarily as an agonist of the glycine receptor, which is a ligand-gated chloride channel in neurons located in the spinal cord and in the brain. This chloride channel will allow the negatively charged chloride ions into the neuron, causing a hyperpolarization which pushes the membrane potential further from threshold. Strychnine is an antagonist of glycine, which means it binds to the same receptor, preventing the inhibitory effects of glycine on the postsynaptic neuron. Therefore, action potentials are triggered with lower levels of excitatory neurotransmitters. When the inhibitory signals are prevented, the motor neurons do will be more easliy activated and the victim will have spastic muscle contractions. Structure of strychnine in complex with ACh binding protein (AChBP). Strychnine is also an antagonist for acetylcholine receptors, which is known to be homologous to the glycine receptor. (Wikipedia) No indication of carcinogenicity to humans (not listed by IARC). Gelsemine is a toxic alkaloid found in the plant Gelsemium sempervirens. 2014-08-29T05:02:45Z 2026-03-27T00:49:48Z C09207 true [H][C@]12CO[C@]3([H])CC1([H])[C@@]1(CN(C)[C@@]2([H])[C@]1([H])[C@@]31C(O)=NC2=CC=CC=C12)C=C C20H22N2O2 InChI=1S/C20H22N2O2/c1-3-19-10-22(2)16-11-9-24-15(8-13(11)19)20(17(16)19)12-6-4-5-7-14(12)21-18(20)23/h3-7,11,13,15-17H,1,8-10H2,2H3,(H,21,23)/t11-,13?,15+,16+,17-,19-,20-/m0/s1 NFYYATWFXNPTRM-ICFOCEFXSA-N 322.4009 322.168127958 Exogenous Solid 4575404 CHEM003031 DTXSID40878487 NS00006472 45.06 93.51970000000001 34.654657962418995 1 4 1 3.880663333632059 10.207084079049931 1 6 1.49 -3.56 8.78e-02 g/l Organic compounds Alkaloids and derivatives Gelsemium alkaloids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 776t3gAAAAAQAAAAAwAAAAAAAAAYAAAAHQAAAIABBiA0AAAAAQEEBgBgAAAA AgIIACAAAAACBiA0AAAAAgEEBgBgAAAAAgIGADAAAAABBAYgJAAAAAEEBgBg AAAAAgIHACAAAAADBgBgAAAAAQMGIDQAAAABAQQGIDQAAAACAQQGICQAAAAC BAYAKAAAAAMECABoAAAAAwEBBwAoAAAAAwMGQCgAAAADBAZAaAAAAAMDAQZA aAAAAAMDAQZAaAAAAAMDAQZAaAAAAAMDAQZAKAAAAAMEBgBoAAAAAwMBBgBo AAAAAwICCwABAAECAAIDAAMEAAQFAAUGAAYHAAcIAAgJAAgKAAoLAAsMAAwN AA0OIA0PKAIPECAQEWgMERJoDBITaAwTFGgMFBVoDAYWABYXCAIFAAALBgAV DAAKAAAVEGgMDAMAQgYAAAAGAQIDBAUABgQFBgsMAwUHBgsKCAUNDBUQDwYR EhMUFRAFAAUGCwoXBAAAAAAAAAAW 2026-09-19T04:01:05Z