4344 Creatine Creatine is an amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. Creatine functions as part of the cell's energy shuttle. The high energy phosphate group of ATP is transferred to creatine to form phosphocreatine in the following reaction: Cr + ATP <-> PCr + ADP. This reaction is reversibly catalyzed by creatine kinase. In the human body creatine is synthesized mainly in the liver by the use of parts from three different amino acids - arginine, glycine, and methionine. 95% of it is later stored in the skeletal muscles, with the rest in the brain, heart, testes. 57-00-1 586 C4H9N3O2 White powder. 255 dec°C 1.33E+004 mg/L (at 18°C) In the muscles, a fraction of the total creatine binds to phosphate - forming creatine phosphate. The reaction is catalysed by creatine kinase, and the result is phosphocreatine (PCr). Phosphocreatine binds with adenosine diphosphate to convert it back to ATP (adenosine triphosphate), an important cellular energy source for short term ATP needs prior to oxidative phosphorylation. Half Life: 3 hours No indication of carcinogenicity to humans (not listed by IARC). For nutritional supplementation, also for treating dietary shortage or imbalance 2014-08-29T06:16:04Z 2026-03-31T18:11:25Z Creatine C00300 16919 CREATINE DB00148 CRN true CN(CC(O)=O)C(N)=N C4H9N3O2 InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) CVSVTCORWBXHQV-UHFFFAOYSA-N 131.1332 131.069476547 Endogenous Solid -0.2 HMDB00064 CHEMBL283800 566 <p>Stefan Weiss, Helmut Krommer, &#8220;Process for the preparation of a creatine or creatine monohydrate.&#8221; U.S. Patent US5719319, issued September, 1963.</p> CHEM003250 DTXSID1040451 NS00009931 2-(N-methylcarbamimidamido)acetic acid