27-Hydroxycholesterol (C27H46O2) is an endogenous compound with an average molecular weight of 402.65 g/mol. It exists as a solid at room temperature. 27-Hydroxycholesterol belongs to the bile acids, alcohols and derivatives, a subclass of steroids and steroid derivatives within the organic compounds.
This metabolite is found in humans and mice and has been detected in fibroblasts, neurons, and the brain. Biologically, it acts as an agonist (PMC10153636) and an inhibitor (PMC4087164). Specifically, it functions as an inhibitor of carboxylesterase (EC 3.1.1.1) and serves as an inducer of apoptosis. Its recorded protein targets include the estrogen receptor beta (ESR2) and the estrogen receptor (ESR1). Additionally, 27-hydroxycholesterol is utilized as a neuroprotective agent.
belongs to the class of organic compounds known as dihydroxy bile acids, alcohols and derivatives. Dihydroxy bile acids, alcohols and derivatives are compounds containing or derived from a bile acid or alcohol, and which bears exactly two carboxylic acid groups.
