4452 Saccharopine Saccharopine is an endogenous compound with the formula C11H20N2O6 and an average molecular weight of 276.29 g/mol. It exists as a solid at room temperature. Saccharopine belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. Biologically, saccharopine serves as a human metabolite and a metabolite of Saccharomyces cerevisiae. It is an intermediate in the degradation of lysine, formed by the condensation of lysine and alpha-ketoglutarate. In mammals, the saccharopine pathway is the primary route for lysine degradation. The first two reactions of this pathway are catalyzed by lysine-oxoglutarate reductase (LOR) and saccharopine dehydrogenase (SDH), which are located on a single bifunctional polypeptide (EC 1.5.1.8, LOR/SDH). This enzyme complex has been detected in the kidney and liver, and LOR activity has been observed in brain mitochondria during embryonic development. Saccharopine interacts with the mitochondrial alpha-aminoadipic semialdehyde synthase (AASS) protein target. 997-68-2 160556 C11H20N2O6 White powder. 247 - 250°C No indication of carcinogenicity to humans (not listed by IARC). This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation. 2014-08-29T06:50:55Z 2026-05-14T18:06:01Z Saccharopine C00449 16927 SACCHAROPINE DB04207 SHR true N[C@@H](CCCCN[C@@H](CCC(O)=O)C(O)=O)C(O)=O C11H20N2O6 InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/t7-,8-/m0/s1 ZDGJAHTZVHVLOT-YUMQZZPRSA-N 276.2863 276.132136382 Endogenous Solid -5.4 HMDB00279 141086 CHEM003358 (2S)-2-{[(5S)-5-amino-5-carboxypentyl]amino}pentanedioic acid 149.95 63.95300000000001 28.138708375547512 11 8 5 1.4444535649435268 10.892138404544818 -1 0 -2.77 -1.72 5.25e+00 g/l Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues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 ï¾­Þ������������������������€���`������ 4��������`�������`�������`�������`�������`������ 4��������`�������`�������(�������h��������(�������(�������h��������(�������(�������h��������(������������������������������� � � � �(�� � � �(������ ��(�B�������������� 2026-09-19T04:01:16Z