4601 Triflumizole Triflumizole is a conazole fungicide used to control powdery mildew, scab and other diseases on top fruit, grapes and other crops. Its mode of action is systemic with protective and curative action. It is an inhibitor of chitin biosynthesis. 68694-11-1 and 99387-89-0 C15H15ClF3N3O White powder. Not listed by IARC. This is a man-made compound that is used as a pesticide. In human, a neuromuscular impairment and decreased locomotor activity were observed following a single exposure of 100 mg/kg/day. The liver is the primary target organ of triflumizole in the rat, mouse, and dog. It increased liver weight, hepatocyte fatty vacuolization, hypertrophy, inflammation, fatty degeneration, and caused necrosis. Chronic effects of triflumizole included hepatocyte fatty vacuolization, hepatocyte hypertrophy, focal inflammation, and necrosi,; fatty degeneration, eosinophilic foci of hepatocyte alteration, hepatic nodules, bile duct hyperplasia, and hyaline degeneration/fibrosis of the bile duct. Liver effects were seen in rat and mouse subchronic and chronic/carcinogenicity studies. The fetal effects were also seen in rats. Triflumizole has a reproductive toxicity as well, the gestation length was increased in rats receiving high dose of triflumizole. 2014-08-29T06:51:46Z 2026-03-27T00:35:52Z C18493 true CCCOC\C(=N/C1=C(C=C(Cl)C=C1)C(F)(F)F)N1C=CN=C1 C15H15ClF3N3O InChI=1S/C15H15ClF3N3O/c1-2-7-23-9-14(22-6-5-20-10-22)21-13-4-3-11(16)8-12(13)15(17,18)19/h3-6,8,10H,2,7,9H2,1H3/b21-14+ HSMVPDGQOIQYSR-KGENOOAVSA-N 345.747 345.085574439 Exogenous Solid CHEMBL463781 82801 CHEM003507 DTXSID2032500 NS00006114 39.41 83.82880000000002 31.912245127704182 6 3 0 6.30562430898208 0 2 3.55 -4.99 3.55e-03 g/l